ID A0A1U8D0E5_MESAU Unreviewed; 561 AA.
AC A0A1U8D0E5;
DT 10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT 10-MAY-2017, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE SubName: Full=Numb-like protein isoform X2 {ECO:0000313|RefSeq:XP_012981062.1, ECO:0000313|RefSeq:XP_012981064.1};
GN Name=Numbl {ECO:0000313|RefSeq:XP_012981062.1,
GN ECO:0000313|RefSeq:XP_012981064.1};
OS Mesocricetus auratus (Golden hamster).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC Cricetidae; Cricetinae; Mesocricetus.
OX NCBI_TaxID=10036 {ECO:0000313|Proteomes:UP000189706, ECO:0000313|RefSeq:XP_012981064.1};
RN [1] {ECO:0000313|RefSeq:XP_012981062.1, ECO:0000313|RefSeq:XP_012981064.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Plays a role in the process of neurogenesis.
CC {ECO:0000256|PIRNR:PIRNR017607}.
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DR RefSeq; XP_012981062.1; XM_013125608.2.
DR RefSeq; XP_012981064.1; XM_013125610.2.
DR RefSeq; XP_012981065.1; XM_013125611.1.
DR OrthoDB; 2913102at2759; -.
DR Proteomes; UP000189706; Unplaced.
DR GO; GO:0007399; P:nervous system development; IEA:UniProtKB-KW.
DR GO; GO:0050769; P:positive regulation of neurogenesis; IEA:UniProtKB-UniRule.
DR CDD; cd01268; PTB_Numb; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR016698; Numb/numb-like.
DR InterPro; IPR010449; Numb_domain.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR006020; PTB/PI_dom.
DR PANTHER; PTHR47368; NUMB; 1.
DR PANTHER; PTHR47368:SF4; NUMB-LIKE PROTEIN; 1.
DR Pfam; PF06311; NumbF; 1.
DR Pfam; PF00640; PID; 1.
DR PIRSF; PIRSF017607; Numb/numb-like; 1.
DR SMART; SM00462; PTB; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS01179; PID; 1.
PE 4: Predicted;
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473,
KW ECO:0000256|PIRNR:PIRNR017607};
KW Neurogenesis {ECO:0000256|PIRNR:PIRNR017607};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000189706}.
FT DOMAIN 37..162
FT /note="PID"
FT /evidence="ECO:0000259|PROSITE:PS01179"
FT REGION 1..22
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 182..246
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 331..415
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 487..561
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 331..352
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 381..402
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 508..525
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 561 AA; 59772 MW; 12192A0DA8E37FD6 CRC64;
MNKLRQSLRR RKPAYVPEAS RPHQWQADED AVRKGTCSFP VRYLGHVEVE ESRGMHVCED
AVKKLKAMGR KSVKSVLWVS ADGLRVVDDK TKDLLVDQTI EKVSFCAPDR NLDKAFSYIC
RDGTTRRWIC HCFLALKDSG ERLSHAVGCA FAACLERKQR REKECGVTAA FDASRTSFAR
EGSFRLSGGG RPAERETGDK KKAEAAAAPA AAPGPAQPGH VSPTPATTSP GEKGEAGTPA
AAGTTAAAIP RRHAPLEQLV RQGSFRGFPA LSQKNSPFKR QLSLRLNELP STLQRRTDFQ
VKGTVPEMEP PGTSDSDGIN ALCTQISSSF ASTGVTASGP PSAPTGTSAW GEPSTPPAAA
FQPGHKRTPS EAERWLEEVS QAARAQQQQQ QQQQQQQQAA SVPPMPAMAP TLPPFSAPVG
PFDTAAAPVA VFLPPTHMQP PFVPAYPGLG YPPMPRVPVV GITPSQMVAN VFCSAAQLQP
QPATLLGKAG AFPPPAASSA PGGQARPRPN GAPWPPEPAP APAPELDPFE AQWAALEGKP
AAEKPSNPFS GDLQKTFEIE L
//
