ID A0A1U8D185_ALLSI Unreviewed; 1499 AA.
AC A0A1U8D185;
DT 10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT 10-MAY-2017, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE SubName: Full=Pleckstrin homology domain-containing family H member 2 isoform X2 {ECO:0000313|RefSeq:XP_006022904.1};
GN Name=PLEKHH2 {ECO:0000313|RefSeq:XP_006022904.1};
OS Alligator sinensis (Chinese alligator).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Crocodylia; Alligatoridae; Alligatorinae;
OC Alligator.
OX NCBI_TaxID=38654 {ECO:0000313|Proteomes:UP000189705, ECO:0000313|RefSeq:XP_006022904.1};
RN [1] {ECO:0000313|RefSeq:XP_006022904.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_006022904.1; XM_006022842.3.
DR RefSeq; XP_014375037.1; XM_014519551.1.
DR RefSeq; XP_014375038.1; XM_014519552.1.
DR RefSeq; XP_014375039.1; XM_014519553.1.
DR GeneID; 102378860; -.
DR KEGG; asn:102378860; -.
DR CTD; 130271; -.
DR eggNOG; KOG0248; Eukaryota.
DR OrthoDB; 4538469at2759; -.
DR Proteomes; UP000189705; Unplaced.
DR GO; GO:0005856; C:cytoskeleton; IEA:InterPro.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR CDD; cd14473; FERM_B-lobe; 1.
DR CDD; cd13206; FERM_C-lobe_PLEKHH1_PLEKHH2; 1.
DR CDD; cd17179; FERM_F1_PLEKHH2; 1.
DR CDD; cd13282; PH1_PLEKHH1_PLEKHH2; 1.
DR Gene3D; 1.20.80.10; -; 1.
DR Gene3D; 1.25.40.530; MyTH4 domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 3.
DR InterPro; IPR019749; Band_41_domain.
DR InterPro; IPR014352; FERM/acyl-CoA-bd_prot_sf.
DR InterPro; IPR035963; FERM_2.
DR InterPro; IPR019748; FERM_central.
DR InterPro; IPR000299; FERM_domain.
DR InterPro; IPR000857; MyTH4_dom.
DR InterPro; IPR038185; MyTH4_dom_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR22903:SF3; PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY H MEMBER 2; 1.
DR PANTHER; PTHR22903; PLEKHH PROTEIN; 1.
DR Pfam; PF00373; FERM_M; 1.
DR Pfam; PF00784; MyTH4; 1.
DR Pfam; PF00169; PH; 1.
DR SMART; SM00295; B41; 1.
DR SMART; SM00139; MyTH4; 1.
DR SMART; SM00233; PH; 2.
DR SUPFAM; SSF50729; PH domain-like; 2.
DR SUPFAM; SSF47031; Second domain of FERM; 1.
DR PROSITE; PS50057; FERM_3; 1.
DR PROSITE; PS51016; MYTH4; 1.
DR PROSITE; PS50003; PH_DOMAIN; 2.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000189705}.
FT DOMAIN 710..804
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 818..926
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 962..1117
FT /note="MyTH4"
FT /evidence="ECO:0000259|PROSITE:PS51016"
FT DOMAIN 1128..1458
FT /note="FERM"
FT /evidence="ECO:0000259|PROSITE:PS50057"
FT REGION 205..225
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 238..322
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 351..449
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 528..553
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 619..712
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1480..1499
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 28..158
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 244..262
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 269..289
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 301..322
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 357..373
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 376..394
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 395..412
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 631..645
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 686..709
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1499 AA; 168975 MW; 425B483AAADC4C79 CRC64;
MADFSDSEGA VNWKERCLTL ESQLMKFRLQ ASKIRELLAE KMQQLEREVI DADRQAERAF
QQVQVMEEKL KAANIQTSES EIRLYKRCQD LETLVQEKDD IIQNLEQQLE EQKQTRIQEA
KIIEEKAAKI KEWVTVKLHE LEVENQNLRL INQKQTEELR TIQSKVQEVL GKKSASSAQK
PGEGQRLSSV TFGCFLNRAK SPQQATKFEE IRKASTKESE FSEDHNILEK EIQEIKFAGP
HENNKRQKSL QQSSCESEQN KNVRTSRSSK DIDSSISKNS YITGSDWSSD EDEGGNERPK
SRCASTLSSH TSEESTRYSR VGSEMYLTAS DDSSSFFEEE SFGIQRTEHK KLYPWQQGSP
WRSQNSSVGK SNPEFLGNKK DQDSSSDELN KKFQSQRLDY SSSSSEANTP SPILTPALAP
KRSVLTPSAG SQFVPQSGSP TNLPPPKLRT PNVFSINLAL AKKHLSQPQL SSDRMFGRNR
NAISMIRPWR PQETDIDLVD GESTNVLEKM EIGYGEGVFT YDSVEVESAE DQEPCETTRK
GGSNKPPTPP LHRFPSWESR IYAVAKSGLR MSEAFNVEAF NKSAASITSC SISGLYTSLI
YKNMTTPVYT TLKGKATQIS NSPFIDDSSG SEEEDSSRSS SRTSESDSRS RIGPGSPRAL
KRGVSLSSMT SESDYAIPPD AYSTDTDYSE PEQKLPKTCS SSSDNGKNEP LEKSGYLLKM
SGKVKTWKRR WFVLKGGELL YYKSPSDVIR KPQGQVELSA SSHIVRGDGK QTVQLTTKKR
AYYLTADSPN ILEEWIKVLQ NVLKVQAASP LFIQPDVKPT MKGLLTKVKH GYSKRVWCTL
VGKTLYYFRN QEDKFPLGQI KLWEAKVEEV DRSCDSDEDY EASGRSLLST HYTVVIHPKE
QGPTYLLIGS KHEKDTWLYH LSVAAGSTNI NVGSEFEQLV CKLLNVEGDP SSQIWRHPTL
CHSKEGIASP LTTLPSEALQ TEAIKLFKTC QLFINAAVDS PAIDYHVSLA QSALQICLTH
PELQNEICCQ LIKQTRRRHP QNQAGPIQGL QLLALCVGLF LPQHPFLWLL KLHLKKNADS
RTEFGKYAIY CQRCVERTQQ NGDREAKPSR MEILSTLLRN PYHHSLPFSI PVHFMNGIYQ
VVGFDASTTV EEFLYTLNQD TGMRKPAQSG FALFTDDPSG KDIEHCLQGN IKICDIISKW
EQASKEQHPG KCEGTRTVRL TYKNRLYFSA QVHGETDREK LLLMHQTNDH IVNGLFPVNK
ELALEMAALL AQVEIGDFER PFSTPAGQGT SQSKSNQTLK QVVERFYPKR YKQGCSEEQL
RQLCQRLSTR WMALRGHSAA DCVRIYLTVA RKWSFFGAKL FVAKPQTTST LESSFIWLAV
HEDGISTLEY SSMRLIVTYG HRSLMTFGGY QDDFMLVVSN TQTKDKPTEK LLFAMAKPKI
LEITLLIASY INYLHQQKGA DHHLSAPALP SLKTVQKTKE MGSQPLLSNS RPTKCPTLL
//
