ID   A0A1U8D1R7_MESAU        Unreviewed;       411 AA.
AC   A0A1U8D1R7;
DT   10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT   10-MAY-2017, sequence version 1.
DT   27-MAR-2024, entry version 30.
DE   SubName: Full=G-protein coupled receptor family C group 5 member B isoform X2 {ECO:0000313|RefSeq:XP_012982053.1};
GN   Name=Gprc5b {ECO:0000313|RefSeq:XP_012982053.1};
OS   Mesocricetus auratus (Golden hamster).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC   Cricetidae; Cricetinae; Mesocricetus.
OX   NCBI_TaxID=10036 {ECO:0000313|Proteomes:UP000189706, ECO:0000313|RefSeq:XP_012982053.1};
RN   [1] {ECO:0000313|RefSeq:XP_012982053.1}
RP   IDENTIFICATION.
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC       Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   RefSeq; XP_012982053.1; XM_013126599.2.
DR   AlphaFoldDB; A0A1U8D1R7; -.
DR   STRING; 10036.ENSMAUP00000018241; -.
DR   OrthoDB; 4263681at2759; -.
DR   Proteomes; UP000189706; Unplaced.
DR   GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR   GO; GO:0070062; C:extracellular exosome; IEA:Ensembl.
DR   GO; GO:0005730; C:nucleolus; IEA:Ensembl.
DR   GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR   GO; GO:0030295; F:protein kinase activator activity; IEA:Ensembl.
DR   CDD; cd15278; 7tmC_RAIG2_GPRC5B; 1.
DR   InterPro; IPR017978; GPCR_3_C.
DR   PANTHER; PTHR14511; G PROTEIN COUPLED RECEPTOR, CLASS C, GROUP 5; 1.
DR   PANTHER; PTHR14511:SF9; G-PROTEIN COUPLED RECEPTOR FAMILY C GROUP 5 MEMBER B; 1.
DR   Pfam; PF00003; 7tm_3; 1.
DR   PROSITE; PS50259; G_PROTEIN_RECEP_F3_4; 1.
PE   4: Predicted;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Receptor {ECO:0000256|ARBA:ARBA00023170,
KW   ECO:0000313|RefSeq:XP_012982053.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000189706};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transducer {ECO:0000256|ARBA:ARBA00023224};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   SIGNAL          1..27
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           28..411
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5010572567"
FT   TRANSMEM        54..81
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        93..115
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        127..147
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        159..183
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        203..222
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        234..256
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        271..289
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          95..311
FT                   /note="G-protein coupled receptors family 3 profile"
FT                   /evidence="ECO:0000259|PROSITE:PS50259"
FT   REGION          356..381
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   411 AA;  45754 MW;  5D732FCD657D1673 CRC64;
     MFLVSERKMR THQVFPLPLL LVIASVASEN ASTSRGCGLD LLPQYVSLCD LDAIWGIVVE
     AVAGAGALIT LLLMLILLVR LPFIKDKEKR RPVCLLFLFL LGTLGLFGLT FAFIIRMDET
     ICSIRRFLWG VLFALCFSCL LSQAWRVRRL VRQGTSPAGW QLVSLALCLM LVQVIIATEW
     LVLTVLRDTK PACAYEPMDF VMALIYDMVL LAITLAQSLF TLCGKFRRWK VNGAFILVTT
     FLSVLIWVVW MTMYLFSSSI VKQGDAWSDP TLAITLAASG WVFVIFYAIP EIHCTLLPPL
     QENPPNYFDT SQPRMRETAF EEDIHLPRAY MENKAFSMDE HNAALRAAAG FSNGSLGKRS
     SGSLGKKPSS LGSRPSAPFR SNVYQPTEMA VVLNGGTIPT APPSHTGRHH W
//