ID A0A1U8D3I3_ALLSI Unreviewed; 495 AA.
AC A0A1U8D3I3;
DT 10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT 10-MAY-2017, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE RecName: Full=Palmitoyltransferase {ECO:0000256|RuleBase:RU079119};
DE EC=2.3.1.225 {ECO:0000256|RuleBase:RU079119};
GN Name=ZDHHC14 {ECO:0000313|RefSeq:XP_014374831.1};
OS Alligator sinensis (Chinese alligator).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Crocodylia; Alligatoridae; Alligatorinae;
OC Alligator.
OX NCBI_TaxID=38654 {ECO:0000313|Proteomes:UP000189705, ECO:0000313|RefSeq:XP_014374831.1};
RN [1] {ECO:0000313|RefSeq:XP_014374831.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=hexadecanoyl-CoA + L-cysteinyl-[protein] = CoA + S-
CC hexadecanoyl-L-cysteinyl-[protein]; Xref=Rhea:RHEA:36683, Rhea:RHEA-
CC COMP:10131, Rhea:RHEA-COMP:11032, ChEBI:CHEBI:29950,
CC ChEBI:CHEBI:57287, ChEBI:CHEBI:57379, ChEBI:CHEBI:74151;
CC EC=2.3.1.225; Evidence={ECO:0000256|ARBA:ARBA00023340};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:36684;
CC Evidence={ECO:0000256|ARBA:ARBA00023340};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- DOMAIN: The DHHC domain is required for palmitoyltransferase activity.
CC {ECO:0000256|RuleBase:RU079119}.
CC -!- SIMILARITY: Belongs to the DHHC palmitoyltransferase family.
CC {ECO:0000256|RuleBase:RU079119}.
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DR RefSeq; XP_014374831.1; XM_014519345.2.
DR AlphaFoldDB; A0A1U8D3I3; -.
DR STRING; 38654.A0A1U8D3I3; -.
DR GeneID; 102369900; -.
DR CTD; 79683; -.
DR InParanoid; A0A1U8D3I3; -.
DR OrthoDB; 5480099at2759; -.
DR Proteomes; UP000189705; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0019706; F:protein-cysteine S-palmitoyltransferase activity; IEA:UniProtKB-EC.
DR InterPro; IPR001594; Palmitoyltrfase_DHHC.
DR PANTHER; PTHR22883:SF28; PALMITOYLTRANSFERASE ZDHHC14; 1.
DR PANTHER; PTHR22883; ZINC FINGER DHHC DOMAIN CONTAINING PROTEIN; 1.
DR Pfam; PF01529; DHHC; 1.
DR PROSITE; PS50216; DHHC; 1.
PE 3: Inferred from homology;
KW Acyltransferase {ECO:0000256|ARBA:ARBA00023315,
KW ECO:0000256|RuleBase:RU079119}; Membrane {ECO:0000256|RuleBase:RU079119};
KW Reference proteome {ECO:0000313|Proteomes:UP000189705};
KW Transferase {ECO:0000256|RuleBase:RU079119};
KW Transmembrane {ECO:0000256|RuleBase:RU079119};
KW Transmembrane helix {ECO:0000256|RuleBase:RU079119}.
FT TRANSMEM 65..83
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU079119"
FT TRANSMEM 95..112
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU079119"
FT TRANSMEM 215..239
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU079119"
FT TRANSMEM 259..283
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU079119"
FT DOMAIN 169..293
FT /note="Palmitoyltransferase DHHC"
FT /evidence="ECO:0000259|Pfam:PF01529"
FT REGION 1..40
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 13..30
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 495 AA; 54114 MW; 4B1F179D03600A08 CRC64;
MSPGGGSGPM KDCEYSQIST HSSSSPMESP HKKKQAGPQR KWEVFPGRNK FFCNGRIMMA
RQTGVFYLTV VLILVTSGLF FAFDCPYLSE KITPAIPAIG GILFFFVMGT LLRTSFSDPG
VLPRATPDEA ADLERQIGNT EDIANGSSSG GYRPPPRTKE VIINGQTVKL KYCFTCKIFR
PPRASHCSLC DNCVERFDHH CPWVGNCVGK RNYRFFYMFI LSLSFLTVFI FAFVITHVIL
RSQQTGFLNA LKDSPASVLE AVVCFFSVWS IVGLSGFHTY LISSNQTTNE DIKGSWSNKR
GKENYNPYSY GNIFTNCCAA LCGPLSPSLI DRRGFLQPDT PQLAAPSNGI TMYGATQSQS
NMCDQDQCIQ STKFVLQAAA TPLLQSEPSI TSEELPLPGK TTISAPCATL TLGQPTPPSS
MPNLTSETGL TDMLPLKEEH EGHQFLTPEE APSPPGMLPT GSPITHSHTM HVLSLASQDS
LHEDSVRGLV KLSSV
//
