ID A0A1U8D3I4_ALLSI Unreviewed; 514 AA.
AC A0A1U8D3I4;
DT 10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 2.
DT 27-MAR-2024, entry version 28.
DE SubName: Full=Signal transducing adapter molecule 2 isoform X1 {ECO:0000313|RefSeq:XP_014375832.2};
GN Name=STAM2 {ECO:0000313|RefSeq:XP_014375832.2};
OS Alligator sinensis (Chinese alligator).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Crocodylia; Alligatoridae; Alligatorinae;
OC Alligator.
OX NCBI_TaxID=38654 {ECO:0000313|Proteomes:UP000189705, ECO:0000313|RefSeq:XP_014375832.2};
RN [1] {ECO:0000313|RefSeq:XP_014375832.2}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Early endosome membrane
CC {ECO:0000256|ARBA:ARBA00004469}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004469}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004469}.
CC -!- SIMILARITY: Belongs to the STAM family.
CC {ECO:0000256|ARBA:ARBA00009666}.
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DR RefSeq; XP_014375832.2; XM_014520346.2.
DR AlphaFoldDB; A0A1U8D3I4; -.
DR STRING; 38654.A0A1U8D3I4; -.
DR InParanoid; A0A1U8D3I4; -.
DR OrthoDB; 620063at2759; -.
DR Proteomes; UP000189705; Unplaced.
DR GO; GO:0031901; C:early endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0035091; F:phosphatidylinositol binding; IEA:InterPro.
DR GO; GO:0043130; F:ubiquitin binding; IEA:InterPro.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR CDD; cd21390; GAT_STAM2; 1.
DR CDD; cd11963; SH3_STAM2; 1.
DR Gene3D; 1.20.5.1940; -; 1.
DR Gene3D; 1.25.40.90; -; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR008942; ENTH_VHS.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR InterPro; IPR035675; STAM2_SH3.
DR InterPro; IPR003903; UIM_dom.
DR InterPro; IPR002014; VHS_dom.
DR PANTHER; PTHR45929; JAK PATHWAY SIGNAL TRANSDUCTION ADAPTOR MOLECULE; 1.
DR PANTHER; PTHR45929:SF1; SIGNAL TRANSDUCING ADAPTER MOLECULE 2; 1.
DR Pfam; PF00018; SH3_1; 1.
DR Pfam; PF02809; UIM; 1.
DR Pfam; PF00790; VHS; 1.
DR PRINTS; PR00499; P67PHOX.
DR PRINTS; PR00452; SH3DOMAIN.
DR SMART; SM00326; SH3; 1.
DR SMART; SM00726; UIM; 1.
DR SMART; SM00288; VHS; 1.
DR SUPFAM; SSF48464; ENTH/VHS domain; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS50002; SH3; 1.
DR PROSITE; PS50330; UIM; 1.
DR PROSITE; PS50179; VHS; 1.
PE 3: Inferred from homology;
KW Endosome {ECO:0000256|ARBA:ARBA00022753};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW Reference proteome {ECO:0000313|Proteomes:UP000189705};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT DOMAIN 4..131
FT /note="VHS"
FT /evidence="ECO:0000259|PROSITE:PS50179"
FT DOMAIN 191..250
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
SQ SEQUENCE 514 AA; 56529 MW; 5F848E172112E6BE CRC64;
MEKATNEYNT SEDWGLIMDI CDKVGSTPNG AKDCLKAIMK RVNHKVPHVA LQALTLLGAC
VSNCGKIFHL EICSRDFASE VRVIINKAHP KVCEKLKALM VEWSEEFQKD PQFSLIAATI
KSLKEEGITF PAAGSQTVPS VAKNGASSSS KNKEDEDIAK AIELSLQEQK QQQMETKSLY
PSAEIQQNNQ KISRKVRALY DFEAVEDNEL TFKSGEIIIV LDDSDTNWWK GENHRGVGLF
PSNFVTSNLN VEPETAAVDK TSVTEDTTEE IKKAEPEPVY IDEDKMDKAL QVLQSIDPTD
SKPDSPDLLD LEDVCQQMGP MIDEKLEEID RKHSEFSELN VKVLEALELY NKLMNEAPLY
SAYSKLHSQA QYPPTSAGVP VQPYPLQPPG GNYMIQGVHQ VTLPQGYSLG PDQMGQLRSL
PQSLNTSGAT QPAQTAYISA GPDSVSNPTY MNQNSGLQSA TSQAAYTQQM GMSVDMSAYQ
NTTSSLPQGT GYPMAVSAPS VLPPQTNYHQ QPLL
//
