ID   A0A1U8D7T9_ALLSI        Unreviewed;       872 AA.
AC   A0A1U8D7T9;
DT   10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT   10-MAY-2017, sequence version 1.
DT   27-MAR-2024, entry version 27.
DE   RecName: Full=Anoctamin {ECO:0000256|RuleBase:RU280814};
GN   Name=ANO6 {ECO:0000313|RefSeq:XP_014377332.1};
OS   Alligator sinensis (Chinese alligator).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Crocodylia; Alligatoridae; Alligatorinae;
OC   Alligator.
OX   NCBI_TaxID=38654 {ECO:0000313|Proteomes:UP000189705, ECO:0000313|RefSeq:XP_014377332.1};
RN   [1] {ECO:0000313|RefSeq:XP_014377332.1}
RP   IDENTIFICATION.
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC       Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU280814}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141,
CC       ECO:0000256|RuleBase:RU280814}.
CC   -!- SIMILARITY: Belongs to the anoctamin family.
CC       {ECO:0000256|ARBA:ARBA00009671, ECO:0000256|RuleBase:RU280814}.
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DR   RefSeq; XP_014377332.1; XM_014521846.2.
DR   AlphaFoldDB; A0A1U8D7T9; -.
DR   GeneID; 102376501; -.
DR   CTD; 196527; -.
DR   OrthoDB; 534027at2759; -.
DR   Proteomes; UP000189705; Unplaced.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR   InterPro; IPR032394; Anoct_dimer.
DR   InterPro; IPR007632; Anoctamin.
DR   InterPro; IPR049452; Anoctamin_TM.
DR   PANTHER; PTHR12308; ANOCTAMIN; 1.
DR   PANTHER; PTHR12308:SF21; ANOCTAMIN-6; 1.
DR   Pfam; PF16178; Anoct_dimer; 1.
DR   Pfam; PF04547; Anoctamin; 1.
PE   3: Inferred from homology;
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU280814};
KW   Reference proteome {ECO:0000313|Proteomes:UP000189705};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU280814};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|RuleBase:RU280814}.
FT   TRANSMEM        259..284
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU280814"
FT   TRANSMEM        337..357
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU280814"
FT   TRANSMEM        421..448
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU280814"
FT   TRANSMEM        468..489
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU280814"
FT   TRANSMEM        516..534
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU280814"
FT   TRANSMEM        632..655
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU280814"
FT   TRANSMEM        683..707
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU280814"
FT   TRANSMEM        788..818
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU280814"
FT   DOMAIN          62..210
FT                   /note="Anoctamin dimerisation"
FT                   /evidence="ECO:0000259|Pfam:PF16178"
FT   DOMAIN          248..832
FT                   /note="Anoctamin transmembrane"
FT                   /evidence="ECO:0000259|Pfam:PF04547"
FT   REGION          1..22
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   872 AA;  102117 MW;  EADCE3366A27CF26 CRC64;
     MAALNQDVLV EVEEEDEDEE DGDVVLEELE QTIFPSYGTT SDQKNLHTAE WVEFDRKPDS
     LFFNDGQRRI DFVLVYEDES KKENRTKKLN KKRKQRKREN YESNLISNGL ELEATRSVLD
     EHLIFVKVHA PWEVLCTYAE VMHIKLPLQP NDLKARDSAF NWFSRLFRVD ENIIKPEQEF
     FTAPFEKDHL SNFYIQDKDM FFNPATRSRI SCFRHKSEDP NCPSERYLLY KEWAHPQKIF
     KLQPLDFVRK YYGEKIGIYF AWLGFYTQML LLAAVVGLGC FLYGCITKDN CTWSQEVCDP
     NIGGNIIMCP QCDRECTYWN LTITCESSKK LCMFDSFGTL VFAVFMGIWV TLFLEFWKRR
     QAELEYEWDT VEFLEQEEQI RPEYEARCTH IVMNEITQEE ERVPYTACGK CIRMTCCTSA
     VFFWILLIIA SVIGIIIYRL SVFLVFSSTL PRHINGTEAI QKYLTPQTAT SVTASIISFI
     IIMILNIIYE KVAIMITDYE LPRTQTDYEN SLTMKMFLFQ FVNYYSSCFY IAFFKGKFVG
     YPGDPVYWLG KYRNEECDPG GCLLELTTQL AIIVGGKSIW NNVQEVLLPW IKNLIGRCCT
     AARSEKVIPR WEQDYHLQPI GKLGLFYEYL EMVIQFGFVT LFVASFPLAP LLALINNLLE
     IRIDAWKITT QFRRMVPQKA QDIGAWQPIM QGMAILAVVT NAMIIAFTSD MIPRLVYYWS
     FSVPPYGNHS DYTMKGYINN TLSVFAVSDF RKESKPVPLS WFDNQTTCRY RDFRYPPGHE
     HQYEHNTYYW HVIAAKLAFI VVMEHIIYFV KFIISYAIPD VSKKTKSKIK REKYLTQKLL
     HENHLRVMKK NVGNIADKIL NVTDTTFRPK SE
//