ID A0A1U8D7Y5_ALLSI Unreviewed; 654 AA.
AC A0A1U8D7Y5;
DT 10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT 10-MAY-2017, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE SubName: Full=DNA-binding protein SMUBP-2 {ECO:0000313|RefSeq:XP_014373230.1, ECO:0000313|RefSeq:XP_025054357.1};
GN Name=IGHMBP2 {ECO:0000313|RefSeq:XP_014373230.1,
GN ECO:0000313|RefSeq:XP_025054357.1};
OS Alligator sinensis (Chinese alligator).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Crocodylia; Alligatoridae; Alligatorinae;
OC Alligator.
OX NCBI_TaxID=38654 {ECO:0000313|Proteomes:UP000189705, ECO:0000313|RefSeq:XP_014373230.1};
RN [1] {ECO:0000313|RefSeq:XP_014373230.1, ECO:0000313|RefSeq:XP_025054357.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the DNA2/NAM7 helicase family.
CC {ECO:0000256|ARBA:ARBA00007913}.
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DR RefSeq; XP_014373230.1; XM_014517744.2.
DR RefSeq; XP_025054357.1; XM_025198572.1.
DR STRING; 38654.A0A1U8D7Y5; -.
DR GeneID; 102385093; -.
DR KEGG; asn:102385093; -.
DR CTD; 3508; -.
DR eggNOG; KOG1803; Eukaryota.
DR OrthoDB; 170190at2759; -.
DR Proteomes; UP000189705; Unplaced.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR CDD; cd02641; R3H_Smubp-2_like; 1.
DR CDD; cd18808; SF1_C_Upf1; 1.
DR Gene3D; 4.10.1110.10; AN1-like Zinc finger; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR Gene3D; 3.30.1370.50; R3H-like domain; 1.
DR InterPro; IPR035896; AN1-like_Znf.
DR InterPro; IPR041679; DNA2/NAM7-like_C.
DR InterPro; IPR041677; DNA2/NAM7_AAA_11.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR001374; R3H_dom.
DR InterPro; IPR036867; R3H_dom_sf.
DR InterPro; IPR034072; R3H_Smubp-2.
DR InterPro; IPR047187; SF1_C_Upf1.
DR InterPro; IPR004483; SMUBP-2/Hcs1-like.
DR InterPro; IPR000058; Znf_AN1.
DR NCBIfam; TIGR00376; IGHMBP2 family helicase; 1.
DR PANTHER; PTHR43788:SF19; DNA-BINDING PROTEIN SMUBP-2; 1.
DR PANTHER; PTHR43788; DNA2/NAM7 HELICASE FAMILY MEMBER; 1.
DR Pfam; PF13086; AAA_11; 1.
DR Pfam; PF13087; AAA_12; 1.
DR Pfam; PF01424; R3H; 1.
DR Pfam; PF01428; zf-AN1; 1.
DR SMART; SM00393; R3H; 1.
DR SMART; SM00154; ZnF_AN1; 1.
DR SUPFAM; SSF118310; AN1-like Zinc finger; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF82708; R3H domain; 1.
DR PROSITE; PS51061; R3H; 1.
DR PROSITE; PS51039; ZF_AN1; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW DNA-binding {ECO:0000313|RefSeq:XP_014373230.1,
KW ECO:0000313|RefSeq:XP_025054357.1};
KW Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000189705};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00449}.
FT DOMAIN 377..440
FT /note="R3H"
FT /evidence="ECO:0000259|PROSITE:PS51061"
FT DOMAIN 552..601
FT /note="AN1-type"
FT /evidence="ECO:0000259|PROSITE:PS51039"
FT REGION 313..375
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 438..482
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 501..537
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 610..654
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 442..481
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 517..537
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 620..654
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 654 AA; 72321 MW; 2F15AC6E6EB127A9 CRC64;
MTTVLTQADV VLATNTGASP DGPLKLLPEN HFDLVVIDEC AQALEASCWI PLLKARKCIL
AGDHKQLPPT IISHKAAAKG LSLSLMERLI QKYGESIVRM LTVQYRMHQA IMQWASTEMY
GGRLTAHPSV AHHLLKDLPG VASTEETRIP LLLVDTAGCG LFELEVEDEQ SKGNQGEVRL
VGLHVQALVN AGVKAKDIAV IAPYNLQVDM LREHLCHKYP ELEIKSVDGF QGREKEAVIL
SFVRSNRKGE VGFLAEDRRI NVAVTRARRH VAVVCDSRTV SNQVFLKRLM DYLSEHGEVR
TAFEYLDDIV PENYSHENSQ GHPEQGEGPK TVPLSTPKLQ PHGQKAKPAP GKPILPKPSI
GPAESMNGTG KERMEVKDNS AKFKAMLVDF LESSKAQLDF PPSLNSHDRM LLHQMAEEYG
LQHVSTGEGR QRYLSIRKRP PATVSATVTN KANEQAPSSE SERTPREAPS PGQTGGSSMS
SGKVDLKMLH LERMQQEKAK WEERARRTQE SSVNLVETAG KKHKNEAKGK SATKADNTTA
EEDIDTLISA VVKADNTCGF PRCKASVTTL GQLCLHCNKR YCLSHHIPEV HGCGEKAKVH
ARQRISKEGV LYAGSGSKDK SLDPTKRAHL QRRLDKKLNE LSNQRKSKKK DQEK
//
