ID A0A1U8D813_ALLSI Unreviewed; 925 AA.
AC A0A1U8D813;
DT 10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT 10-MAY-2017, sequence version 1.
DT 27-MAR-2024, entry version 34.
DE RecName: Full=Tyrosine-protein phosphatase {ECO:0000256|PIRNR:PIRNR000927};
DE EC=3.1.3.48 {ECO:0000256|PIRNR:PIRNR000927};
GN Name=PTPN3 {ECO:0000313|RefSeq:XP_014377412.1};
OS Alligator sinensis (Chinese alligator).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Crocodylia; Alligatoridae; Alligatorinae;
OC Alligator.
OX NCBI_TaxID=38654 {ECO:0000313|Proteomes:UP000189705, ECO:0000313|RefSeq:XP_014377412.1};
RN [1] {ECO:0000313|RefSeq:XP_014377412.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] +
CC phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858,
CC ChEBI:CHEBI:82620; EC=3.1.3.48;
CC Evidence={ECO:0000256|PIRNR:PIRNR000927};
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245, ECO:0000256|PIRNR:PIRNR000927}.
CC -!- SIMILARITY: Belongs to the protein-tyrosine phosphatase family. Non-
CC receptor class subfamily. {ECO:0000256|ARBA:ARBA00009649,
CC ECO:0000256|PIRNR:PIRNR000927}.
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DR RefSeq; XP_014377412.1; XM_014521926.2.
DR AlphaFoldDB; A0A1U8D813; -.
DR GeneID; 102370971; -.
DR CTD; 5774; -.
DR OrthoDB; 5345383at2759; -.
DR Proteomes; UP000189705; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0008092; F:cytoskeletal protein binding; IEA:InterPro.
DR GO; GO:0004725; F:protein tyrosine phosphatase activity; IEA:UniProtKB-EC.
DR GO; GO:0016311; P:dephosphorylation; IEA:InterPro.
DR CDD; cd14473; FERM_B-lobe; 1.
DR CDD; cd13189; FERM_C_PTPN4_PTPN3_like; 1.
DR CDD; cd17193; FERM_F1_PTPN3; 1.
DR CDD; cd00992; PDZ_signaling; 1.
DR CDD; cd14600; PTPc-N3; 1.
DR Gene3D; 1.20.80.10; -; 1.
DR Gene3D; 2.30.42.10; -; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 3.90.190.10; Protein tyrosine phosphatase superfamily; 1.
DR InterPro; IPR019749; Band_41_domain.
DR InterPro; IPR014352; FERM/acyl-CoA-bd_prot_sf.
DR InterPro; IPR035963; FERM_2.
DR InterPro; IPR019748; FERM_central.
DR InterPro; IPR019747; FERM_CS.
DR InterPro; IPR000299; FERM_domain.
DR InterPro; IPR018979; FERM_N.
DR InterPro; IPR018980; FERM_PH-like_C.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR InterPro; IPR000242; PTP_cat.
DR InterPro; IPR041783; PTPN3/4_FERM_C.
DR InterPro; IPR016130; Tyr_Pase_AS.
DR InterPro; IPR003595; Tyr_Pase_cat.
DR InterPro; IPR000387; Tyr_Pase_dom.
DR InterPro; IPR012151; Tyr_Pase_non-rcpt_typ-3/4.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR45706; TYROSINE-PROTEIN PHOSPHATASE; 1.
DR PANTHER; PTHR45706:SF5; TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 3; 1.
DR Pfam; PF09380; FERM_C; 1.
DR Pfam; PF00373; FERM_M; 1.
DR Pfam; PF09379; FERM_N; 1.
DR Pfam; PF00595; PDZ; 1.
DR Pfam; PF00102; Y_phosphatase; 1.
DR PIRSF; PIRSF000927; Tyr-Ptase_nr3; 1.
DR PRINTS; PR00935; BAND41.
DR PRINTS; PR00700; PRTYPHPHTASE.
DR SMART; SM00295; B41; 1.
DR SMART; SM01196; FERM_C; 1.
DR SMART; SM00228; PDZ; 1.
DR SMART; SM00194; PTPc; 1.
DR SMART; SM00404; PTPc_motif; 1.
DR SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 1.
DR SUPFAM; SSF50156; PDZ domain-like; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF47031; Second domain of FERM; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR PROSITE; PS00660; FERM_1; 1.
DR PROSITE; PS00661; FERM_2; 1.
DR PROSITE; PS50057; FERM_3; 1.
DR PROSITE; PS50106; PDZ; 1.
DR PROSITE; PS00383; TYR_PHOSPHATASE_1; 1.
DR PROSITE; PS50056; TYR_PHOSPHATASE_2; 1.
DR PROSITE; PS50055; TYR_PHOSPHATASE_PTP; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490, ECO:0000256|PIRNR:PIRNR000927};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212,
KW ECO:0000256|PIRNR:PIRNR000927}; Hydrolase {ECO:0000256|PIRNR:PIRNR000927};
KW Protein phosphatase {ECO:0000256|PIRNR:PIRNR000927};
KW Reference proteome {ECO:0000313|Proteomes:UP000189705}.
FT DOMAIN 29..312
FT /note="FERM"
FT /evidence="ECO:0000259|PROSITE:PS50057"
FT DOMAIN 521..593
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 658..913
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50055"
FT DOMAIN 831..904
FT /note="Tyrosine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS50056"
FT REGION 360..392
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 418..483
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 418..482
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 854
FT /note="Phosphocysteine intermediate"
FT /evidence="ECO:0000256|PIRSR:PIRSR000927-1"
FT BINDING 823
FT /ligand="substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR000927-2"
FT BINDING 854..860
FT /ligand="substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR000927-2"
FT BINDING 898
FT /ligand="substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR000927-2"
SQ SEQUENCE 925 AA; 105846 MW; 8E529B21024BAC1B CRC64;
MNSRLRALGG RINNIRSSEL PKEKTRSEII CNVHFLDGSI QSFKVNKQDT GQILLDMAYN
HLGVTEKEYF GLQQNEEAVD SPRWLETSKP IKKQLKGGFP CTLHFRVRFF IPDPNTLQEE
QTRHLFFLQL KTAILEGRLT CPLNSAVVLA SYAVQAQLGD FNSTEHHSGY LSNFHFLPDQ
NKDFLIKVES LHEQHSGLKQ SEAESCYINI ARTLEFYGVE LHSGRDLHNL DLMIGIASGG
IAVYRKCICT SFYAWANILK ISFKRKKFFI QQRQKHNETR EHIVAFNMLN YRACKNLWKS
CVEHHTFFQA KSLPHENKIF SHYWTLGSRN LTKSVNNQYC RKVIGGMVWN PSMRRSLSVE
HLETKSLPSR SPPVTPNWRS PRLRHEIRKP RHSSVDNLTN EITYITETED VFYTYKVSPT
SKNSDSEVSQ NRSPWRRSPE QESSKNILGN SPSESCLTHT SPNTSTQSPN GVGNTSGSYP
LDGADQQFLE TYDNVTKGST SEDSSQYYCD RNEVIDGDLL SVHITPDEDG KFGFNLKGGV
DQKMPLVVSR ITPGSPADIC IPKLNEGDQI VLINGRDISE HTHDQVVMFI KASRESHTRE
LALLVKRKVL KHFVETKSED EADSQNFQES ILPTCSEYGD TLEESMEQLK KGLENGTVLT
QFEQLYRKKP GLSVTCAKVP QNMDKNRYKD VLPYDATRII LQGDEDYINA NYVTMEIPSA
GIVNRYIATQ GPLPHTCAHF WQVVWDHRLT LIIMLTTLTE RGRTKCHQYW PDPPEIMEYG
NFRVKCQSED CTIAYVFREM VLTNIETEQE HIVTHLQYVA WPDHGVPDDS TDFLEFVNCM
RPKRVKNEPV LVHCSAGIGR TGVLVTMETA LCLIERNQPV YPLDIVRKMR DQRAMMVQTS
SQYKFVCEAI LRVYKEGLVR PLDSS
//
