ID A0A1U8D8K4_ALLSI Unreviewed; 2202 AA.
AC A0A1U8D8K4;
DT 10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT 10-MAY-2017, sequence version 1.
DT 27-MAR-2024, entry version 40.
DE SubName: Full=Dedicator of cytokinesis protein 10 isoform X3 {ECO:0000313|RefSeq:XP_014374049.1};
GN Name=DOCK10 {ECO:0000313|RefSeq:XP_014374049.1};
OS Alligator sinensis (Chinese alligator).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Crocodylia; Alligatoridae; Alligatorinae;
OC Alligator.
OX NCBI_TaxID=38654 {ECO:0000313|Proteomes:UP000189705, ECO:0000313|RefSeq:XP_014374049.1};
RN [1] {ECO:0000313|RefSeq:XP_014374049.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the DOCK family. {ECO:0000256|PROSITE-
CC ProRule:PRU00983}.
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DR RefSeq; XP_014374049.1; XM_014518563.2.
DR GeneID; 102375602; -.
DR KEGG; asn:102375602; -.
DR CTD; 55619; -.
DR eggNOG; KOG1997; Eukaryota.
DR OrthoDB; 5480873at2759; -.
DR Proteomes; UP000189705; Unplaced.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd08697; C2_Dock-D; 1.
DR CDD; cd11699; DHR2_DOCK10; 1.
DR CDD; cd13267; PH_DOCK-D; 1.
DR Gene3D; 1.20.58.740; -; 1.
DR Gene3D; 1.25.40.410; -; 1.
DR Gene3D; 2.60.40.150; C2 domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR037809; C2_Dock-D.
DR InterPro; IPR027007; C2_DOCK-type_domain.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR026791; DOCK.
DR InterPro; IPR021816; DOCK_C/D_N.
DR InterPro; IPR043161; DOCK_C_lobe_A.
DR InterPro; IPR043162; DOCK_C_lobe_C.
DR InterPro; IPR027357; DOCKER_dom.
DR InterPro; IPR046769; DOCKER_Lobe_A.
DR InterPro; IPR046770; DOCKER_Lobe_B.
DR InterPro; IPR046773; DOCKER_Lobe_C.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR23317; DEDICATOR OF CYTOKINESIS DOCK; 1.
DR PANTHER; PTHR23317:SF71; DEDICATOR OF CYTOKINESIS PROTEIN 10; 1.
DR Pfam; PF06920; DHR-2_Lobe_A; 2.
DR Pfam; PF20422; DHR-2_Lobe_B; 1.
DR Pfam; PF20421; DHR-2_Lobe_C; 1.
DR Pfam; PF14429; DOCK-C2; 1.
DR Pfam; PF11878; DOCK_C-D_N; 1.
DR Pfam; PF00169; PH; 1.
DR SMART; SM00233; PH; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS51650; C2_DOCK; 1.
DR PROSITE; PS51651; DOCKER; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 3: Inferred from homology;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000189705}.
FT DOMAIN 196..305
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 687..865
FT /note="C2 DOCK-type"
FT /evidence="ECO:0000259|PROSITE:PS51650"
FT DOMAIN 1705..2165
FT /note="DOCKER"
FT /evidence="ECO:0000259|PROSITE:PS51651"
FT REGION 172..192
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2202 AA; 252374 MW; 88BB99FBFF838A86 CRC64;
MGCAASIVLL QAFRSVVQRN CPHICRRRQE ELSHEILPLD SDDEMSRPRT LIIMQDKPKF
LEPLDYEAVI TEIERNFEDY PLKDLLFFPN DDFSIDTIPW EIRTLSLSVP EDAVQKAENL
FVKEACKYYS SQWHVVNYKY EQYSGDFRHL PQNECRPEKL PSHSFEIDHE DIDKDEDTTS
HSSSKGGGGG GGFGTGVFKS GWLYKGNFNS TINNSITVRS FKKRYFQLTQ LSDNSYIMNF
YKDEKISKEP KGCIFLDSCT GVVQNNRLRK HAFELKMNDL TYFVLAAENE QDMDDWISTL
NKILQINPEG SIQERKSADL TDLKLESADV SINSECQQEE TDLLENTSHP DFIKYIMETE
ETVKTSRHVE RLNLFSLDPD VTTLNPQKKE FLETELMIKP FEEKAAKRIM ITCKSLILNL
QACVTENESD PVTNVEPFFV SVALFDIRDN RKISADFHVD MNHMLVRQMI STSSPSLENG
TIENMDSKET EEPQIKGFPQ EWLKYPKQAL FSISNPHSEI VLVAKIEKIL MGNIASSAEP
YIKNPDSNKC AQKVLKSNKQ FCSKLGKYRM PFAWSVRPVF KDNQGNVDRD SRFSPLFRQE
SSKISTEDLI KLIAEYKRAE KISKIQTIPG SLDIAVDCVP LEHPNCVTSS FIPIKPFNDI
KEHQPTVEVE EFVQESTKYS RPYRVYKNQI YIYPKHLKYD SQKCFSKARN ITVCIEFKSS
DEEGARPLKC IYGKPGGPLF TRAAYTAVLH HSQNPDFYDE VKIELPTQLH TKHHILFSFY
HVTCDINAKA NAKKKEALET PVGYAWLPLL KDAQLASQEH NIPVAASLPP SYLSLQDPAS
GKHCASDIKW VDSGKPLFKV SSFVVSTVNT QDPYLNNFFQ QCQKREKDLS NPPTSNFIIS
CKNLLKIEKI HAIMNFLPVI LNQLFSVLVQ NDVDEVKTAV TRVLTDIVAK CHEEQLEHCV
HSYVKYVFRT KSSEERTVHE ELAKNMTGLL KSNDQLTVKH VLKHSWFFLT IILKSMAQHL
VDTSRIQVPR IQRFPESFQT ELDTLIMNLA DHVVWKHRDA LEETKNANHS VARFLKRCFT
FMDRGFVFKM INSYISMFGA GVPKVLYQYK FDFLQEVCHH EHFIPLCLPI RSVHIPDPMT
PSESTQEYHA SDIPEYTLTN EFCRKHFLIG LLLREVGFAL QEDQDIRHLA LAVLKNLMAK
HSFDDRYAEP EKQAQIANLY MPLYGMLLDN MPRIYMKDMF LFNINTSNQG SRDDLSTAGG
FPNQTAMKHA NSVDTSFSKD VLNSIAAFSS IAISAANHAD SRASLASLDS NPSTNEKNSE
RTDTCEKIVR PLSLIGSTLR FDKLDQAETR SLLMCFLHIM KTISEETLIS YWQRAPLTEI
TDFFSILEVC LQNFRYLGKR NIVRKIAAAF KFVQATQNNG TLKGSNSSCQ TSGLLSQWMH
SASSHDGHKQ HRSQTLPIIR GKNAFSNPKL LQMIENTIAS GSSETDIAHY VDTEANIATE
VCVTILDLLG LFTQNHQRQL QQSDCQNALM KKVFDTYLLF LQINQSAVAL KHVFAALRLF
VSKFPSAFFQ GQADLCGSFC YEILKCCNHR SRSTQTEASA LLYFFMRKNF EFNKQKSIVR
SHLQLIKAVS QLIADAGIGG SRFQHSLAII NNFANGDKQM KNSNFPAEVK DLTKRIRTVL
MATAQMKEHE KDPEMLVDLQ YSLANSYAST PELRRTWLES MAKIHVRNGD LSEAAMCYIH
IAALIAEYLK RKGYWKMEKI CTSRMLLEDA QVSDSNLLLT THTGGSLFSM GWPAFLNITP
NIKEEGAMKE DSGMQDTPYN EGILVEQLEL CVEYLWKSER YELIAEVNKP IIAVFEKQRN
FKKLSELYYD IHRSYLKVTE VVNSEKRLFG RYYRVAFYGQ GFFEEEEGKE YIYKEPKLTG
LSEISQRLLK LYADKFGADN VKIIQDSNKV NPKDLDPKYA YIQVTYVTPF FEEKEAEDRK
TDFEMHHNIN RFVFETPFTL SGKKHGGVEE QCKRRTILTT SHLFPYVKKR IQVISQTSTE
LNPIEVAIDE MSKKVSELNQ LCTMEEVDMI RLQLKLQGSV SVKINAGPMA YARAFLEETN
AKKYPDNQVK LLKEIFRQFA EACGHALEVN ERLIKDDQLE YQEEMKSHYK DMLSELSLVM
NEQITYKEDP AKQQGMERTY SRAISRTNTL VPGALMPSNP EA
//
