ID A0A1U8D9B3_ALLSI Unreviewed; 998 AA.
AC A0A1U8D9B3;
DT 10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT 10-MAY-2017, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE RecName: Full=DIS3-like exonuclease 1 {ECO:0000256|ARBA:ARBA00016366};
DE EC=3.1.13.1 {ECO:0000256|ARBA:ARBA00012163};
GN Name=DIS3L {ECO:0000313|RefSeq:XP_014373735.1,
GN ECO:0000313|RefSeq:XP_025055308.1};
OS Alligator sinensis (Chinese alligator).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Crocodylia; Alligatoridae; Alligatorinae;
OC Alligator.
OX NCBI_TaxID=38654 {ECO:0000313|Proteomes:UP000189705, ECO:0000313|RefSeq:XP_014373735.1};
RN [1] {ECO:0000313|RefSeq:XP_014373735.1, ECO:0000313|RefSeq:XP_025055308.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Exonucleolytic cleavage in the 3'- to 5'-direction to yield
CC nucleoside 5'-phosphates.; EC=3.1.13.1;
CC Evidence={ECO:0000256|ARBA:ARBA00001849};
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|ARBA:ARBA00001946};
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- SIMILARITY: Belongs to the RNR ribonuclease family.
CC {ECO:0000256|ARBA:ARBA00005785, ECO:0000256|RuleBase:RU003901}.
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DR RefSeq; XP_014373735.1; XM_014518249.2.
DR RefSeq; XP_025055308.1; XM_025199523.1.
DR STRING; 38654.A0A1U8D9B3; -.
DR GeneID; 102373465; -.
DR KEGG; asn:102373465; -.
DR CTD; 115752; -.
DR eggNOG; KOG2102; Eukaryota.
DR OrthoDB; 945235at2759; -.
DR Proteomes; UP000189705; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0004527; F:exonuclease activity; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR GO; GO:0004540; F:RNA nuclease activity; IEA:InterPro.
DR Gene3D; 2.40.50.690; -; 1.
DR Gene3D; 2.40.50.700; -; 1.
DR Gene3D; 3.40.50.1010; 5'-nuclease; 1.
DR Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 1.
DR InterPro; IPR041505; Dis3_CSD2.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR InterPro; IPR001900; RNase_II/R.
DR InterPro; IPR022966; RNase_II/R_CS.
DR InterPro; IPR033771; Rrp44_CSD1.
DR PANTHER; PTHR23355:SF30; DIS3-LIKE EXONUCLEASE 1; 1.
DR PANTHER; PTHR23355; RIBONUCLEASE; 1.
DR Pfam; PF17849; OB_Dis3; 1.
DR Pfam; PF00773; RNB; 1.
DR Pfam; PF17216; Rrp44_CSD1; 1.
DR SMART; SM00955; RNB; 1.
DR SUPFAM; SSF50249; Nucleic acid-binding proteins; 3.
DR PROSITE; PS01175; RIBONUCLEASE_II; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Exonuclease {ECO:0000313|RefSeq:XP_014373735.1,
KW ECO:0000313|RefSeq:XP_025055308.1};
KW Hydrolase {ECO:0000313|RefSeq:XP_014373735.1,
KW ECO:0000313|RefSeq:XP_025055308.1};
KW Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Reference proteome {ECO:0000313|Proteomes:UP000189705};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..24
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 25..998
FT /note="DIS3-like exonuclease 1"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5041162111"
FT DOMAIN 409..761
FT /note="Ribonuclease II/R"
FT /evidence="ECO:0000259|SMART:SM00955"
FT COILED 940..972
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 998 AA; 113459 MW; 8AE38C2ECEB6F7E9 CRC64;
MQRQRMLLQA GAWLAGAVLH CWLALHGRSN TAAAVGGSDD SRQYNKLRKL MKDARHDCIL
FANEFQQHSY LPRERGESME KWQTRSIYNA AVWYYNHCLG QMPVVMVTED EDAIRQYGNE
TEGVFVISFK NYLDNFWLDL KAAHELFDSI LQSRRERESE SQENNGKEYP EHLPMEVLEA
GIKSGRYIQG ILNVNKHRAQ VEAFVRLQGA SRKKKDLQSD ILIYGTKARN RAIHGDVVAV
ELLPLHEWKG RTVALCENEA DEKASGDTSS EPMPTGRVVG IIQKNWRDYV VTFPSKEESQ
TQGKNVQKIL VTPWDYRIPK IRISTQQAEA LQDCRVIVRI DAWESTSVYP NGHFVRVLGR
IGDLEGETAA ILVENGISVA PFSEVQMSEM PVSTLENPWR VNPEEELKRI DLRDTHLVFS
IDPKGCEDVD DTLSVRALAN GNLELGVHIA DVTHFVPVNS YTDLEARARA TTYYLADRRY
DMLPSVLSAD ICSLLSGVDR YAVSVMWELD KTSYEIQRVW YNRTIIRSAY KLHYEAAQAL
LDGDLSGVDE ILELKELDER TRQQKLNELV WAIGKLTDIA RHVRAKRDSC GALELEGVEI
RVLLDDKKNI HDLIPKQPLE VHETVAECMI LANHWVAKKI WEKFPQQAML RQHPPPRQEF
FSELRECASA KGFVIDTWSN KALADSLDRA NDPLDPIVNK LLRSMATQAM SNALYFSTGS
CSEEEFHHYG LALDKYTHFT SPIRRYADIA VHRLIVAATL KDTKENIKDS LFSNKDLDEL
CSHINNRNRA AQRAQKQSTE LFQCMYFKDK VAEADERCVA DGVIYSIRTN GVLVFVPRYG
IKAPAYLKNK EGLVISCQSD GSCEWKPGFL QRFQNRITST TTAGESVTLS LFEHITVKIL
GQSSRCHADT LKLEIVSNTP YETTDADVSQ NSHVMKSDLV KEVTKSAEEA QLAQERARAE
IIQEEYQEYC QTKGTSLYQL LEEIRDLDLL DVSAGNRA
//
