ID A0A1U8DB70_ALLSI Unreviewed; 417 AA.
AC A0A1U8DB70;
DT 10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT 10-MAY-2017, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE RecName: Full=Sprouty-related, EVH1 domain-containing protein 2 {ECO:0000256|ARBA:ARBA00039299};
GN Name=SPRED2 {ECO:0000313|RefSeq:XP_014374390.1};
OS Alligator sinensis (Chinese alligator).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Crocodylia; Alligatoridae; Alligatorinae;
OC Alligator.
OX NCBI_TaxID=38654 {ECO:0000313|Proteomes:UP000189705, ECO:0000313|RefSeq:XP_014374390.1};
RN [1] {ECO:0000313|RefSeq:XP_014374390.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004413};
CC Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004413};
CC Cytoplasmic side {ECO:0000256|ARBA:ARBA00004413}. Cytoplasmic vesicle,
CC secretory vesicle membrane {ECO:0000256|ARBA:ARBA00004360}; Peripheral
CC membrane protein {ECO:0000256|ARBA:ARBA00004360}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004360}. Membrane
CC {ECO:0000256|ARBA:ARBA00004287}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004287}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004287}.
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DR RefSeq; XP_014374390.1; XM_014518904.2.
DR AlphaFoldDB; A0A1U8DB70; -.
DR GeneID; 102378448; -.
DR KEGG; asn:102378448; -.
DR CTD; 200734; -.
DR OrthoDB; 3031266at2759; -.
DR Proteomes; UP000189705; Unplaced.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0030658; C:transport vesicle membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0009966; P:regulation of signal transduction; IEA:InterPro.
DR CDD; cd10574; EVH1_SPRED-like; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR023337; KBD.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR041937; SPRE_EVH1.
DR InterPro; IPR007875; Sprouty.
DR InterPro; IPR000697; WH1/EVH1_dom.
DR PANTHER; PTHR11202:SF11; SPROUTY-RELATED, EVH1 DOMAIN-CONTAINING PROTEIN 2; 1.
DR PANTHER; PTHR11202; SPROUTY-RELATED, EVH1 DOMAIN-CONTAINING PROTEIN FAMILY MEMBER; 1.
DR Pfam; PF05210; Sprouty; 1.
DR Pfam; PF00568; WH1; 1.
DR SMART; SM00461; WH1; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS51488; KBD; 1.
DR PROSITE; PS51227; SPR; 1.
DR PROSITE; PS50229; WH1; 1.
PE 4: Predicted;
KW Cytoplasmic vesicle {ECO:0000256|ARBA:ARBA00023329};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Reference proteome {ECO:0000313|Proteomes:UP000189705}.
FT DOMAIN 9..126
FT /note="WH1"
FT /evidence="ECO:0000259|PROSITE:PS50229"
FT DOMAIN 206..260
FT /note="KBD"
FT /evidence="ECO:0000259|PROSITE:PS51488"
FT REGION 126..199
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 149..172
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 175..195
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 417 AA; 47786 MW; 70FB2871DE9DF21D CRC64;
MISQSFLFCY CYSDSYIVRV KAVVMTRDDS SGGWLPQEGG GLSRVGVCKV MYPEGNGRSR
FLIHGERQRD KLVVLECFVK KDLIYTKANP IFHHWKVDNR KFGLTFQSPA DARAFDRGVR
KAIEDLTEGS TTSSSTIHNE AEVGDDDVFT NATDSSSNSS QKREQPVRTL ASPTSCEHRR
IRTRGHIHDP YSSDHYHLEQ QSISRSYRHV SFPDDDEEIV RINPREKIWM TGYEDYRHAP
TRGKNFDTDD VDSYVRFAKS DASKHEYTYP YVDNSEFDLG EDIKSTVIKT QPVKVKSRRK
EDGERSRCIY CRDMFNHEEN RRGQCQDAPD RGRSCIRRVS CMWCADSMLY HCMSDPEGDY
TDPCSCDTSD DMFCLRWMAL IALSFIAPCM CCYFPLQACY HCGVMCSCCG GKHKAAG
//
