ID   A0A1U8DC37_ALLSI        Unreviewed;       706 AA.
AC   A0A1U8DC37;
DT   10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT   10-MAY-2017, sequence version 1.
DT   27-MAR-2024, entry version 33.
DE   SubName: Full=Rho guanine nucleotide exchange factor 16 isoform X1 {ECO:0000313|RefSeq:XP_014378812.1, ECO:0000313|RefSeq:XP_025067863.1};
GN   Name=ARHGEF16 {ECO:0000313|RefSeq:XP_014378812.1,
GN   ECO:0000313|RefSeq:XP_025067863.1};
OS   Alligator sinensis (Chinese alligator).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Crocodylia; Alligatoridae; Alligatorinae;
OC   Alligator.
OX   NCBI_TaxID=38654 {ECO:0000313|Proteomes:UP000189705, ECO:0000313|RefSeq:XP_014378812.1};
RN   [1] {ECO:0000313|RefSeq:XP_014378812.1, ECO:0000313|RefSeq:XP_025067863.1}
RP   IDENTIFICATION.
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   RefSeq; XP_014378812.1; XM_014523326.2.
DR   RefSeq; XP_025067863.1; XM_025212078.1.
DR   STRING; 38654.A0A1U8DC37; -.
DR   GeneID; 102383502; -.
DR   KEGG; asn:102383502; -.
DR   CTD; 27237; -.
DR   eggNOG; KOG3523; Eukaryota.
DR   OrthoDB; 12272at2759; -.
DR   Proteomes; UP000189705; Unplaced.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR   CDD; cd01221; PH_ephexin; 1.
DR   CDD; cd00160; RhoGEF; 1.
DR   Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR   Gene3D; 2.30.30.40; SH3 Domains; 1.
DR   InterPro; IPR035899; DBL_dom_sf.
DR   InterPro; IPR000219; DH-domain.
DR   InterPro; IPR047271; Ephexin-like.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR001849; PH_domain.
DR   InterPro; IPR047270; PH_ephexin.
DR   InterPro; IPR036028; SH3-like_dom_sf.
DR   InterPro; IPR001452; SH3_domain.
DR   PANTHER; PTHR12845; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR   PANTHER; PTHR12845:SF3; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 16; 1.
DR   Pfam; PF00621; RhoGEF; 1.
DR   Pfam; PF14604; SH3_9; 1.
DR   SMART; SM00233; PH; 1.
DR   SMART; SM00325; RhoGEF; 1.
DR   SMART; SM00326; SH3; 1.
DR   SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR   SUPFAM; SSF50729; PH domain-like; 1.
DR   SUPFAM; SSF50044; SH3-domain; 1.
DR   PROSITE; PS50010; DH_2; 1.
DR   PROSITE; PS50003; PH_DOMAIN; 1.
DR   PROSITE; PS50002; SH3; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000189705};
KW   SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW   ProRule:PRU00192}.
FT   DOMAIN          274..458
FT                   /note="DH"
FT                   /evidence="ECO:0000259|PROSITE:PS50010"
FT   DOMAIN          491..617
FT                   /note="PH"
FT                   /evidence="ECO:0000259|PROSITE:PS50003"
FT   DOMAIN          626..686
FT                   /note="SH3"
FT                   /evidence="ECO:0000259|PROSITE:PS50002"
FT   REGION          19..117
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          165..237
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          552..574
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        167..181
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        193..220
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   706 AA;  80301 MW;  D12689174A824AED CRC64;
     MSQRRSEGED KVFLVEHKFR SELHISPSGH RRSLLAMDNA SFSPQPSPSP SPSPSSTDSR
     RIILSTESPA ALKVGTQQMI PKSLAISSRP KAPARHQSFA TVPPNREIPR CDPKRMSAPS
     ISLDEVEFDA GGMLKRNLRN MSYRAAMKVQ GGSEEPEPVR SIASLKPLEE GSTQPAQSPG
     RTKKTFGKRR MQRHGGSFKD DPRLYQEIRE RGLNSIPHES DDDLLEEEPT PEEQPTPDAA
     IVVKSYRPAQ MTWSQLPEVQ EMDILDKISP AERKRQEAIF EIITSEYSYM RSLSILVCHF
     MRSEELKETM TQTQHHHLFS NIGDILNISK SFFEDLEKRY QEHILISEIS DIMEKHALQH
     FHPYVIYCSN EVYQQRTLQK LLATNHAFKE ALKQIERKPE CGGLPMISFL ILPMQRVTRL
     PLLMETVCQK TNPYSTTYET ATQALRAISK LVKSCNEGAH TMERTEQMYT LQTQLEFGKI
     KPFPLISASR WLLKRGELAL FHGEEVGIFR KGRVNCYLFL FNDVLIITKK KSEESYTVMD
     YAKLDQVVVE KIESPDPPSS PPGKPGAGGT ARSPWNGHLF RVILKKNSEG RREEIVLSAE
     SLSNRARWIT ALMHRENAQN DTSSKGDLSQ VEIIRAHLAK QTDEISLQQG DVVLVLGGED
     GWYLGERLRD GERGWFPQSC AQQITDRSAV ERNVRRLERL RIETDV
//