ID A0A1U8DCC6_ALLSI Unreviewed; 566 AA.
AC A0A1U8DCC6;
DT 10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 2.
DT 24-JAN-2024, entry version 28.
DE RecName: Full=Transcription initiation factor IIF subunit alpha {ECO:0000256|RuleBase:RU366044};
GN Name=GTF2F1 {ECO:0000313|RefSeq:XP_014375374.2};
OS Alligator sinensis (Chinese alligator).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Crocodylia; Alligatoridae; Alligatorinae;
OC Alligator.
OX NCBI_TaxID=38654 {ECO:0000313|Proteomes:UP000189705, ECO:0000313|RefSeq:XP_014375374.2};
RN [1] {ECO:0000313|RefSeq:XP_014375374.2}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: TFIIF is a general transcription initiation factor that binds
CC to RNA polymerase II and helps to recruit it to the initiation complex
CC in collaboration with TFIIB. It promotes transcription elongation.
CC {ECO:0000256|ARBA:ARBA00025232, ECO:0000256|RuleBase:RU366044}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|RuleBase:RU366044}.
CC -!- SIMILARITY: Belongs to the TFIIF alpha subunit family.
CC {ECO:0000256|ARBA:ARBA00005249, ECO:0000256|RuleBase:RU366044}.
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DR RefSeq; XP_014375374.2; XM_014519888.2.
DR STRING; 38654.A0A1U8DCC6; -.
DR KEGG; asn:102371558; -.
DR InParanoid; A0A1U8DCC6; -.
DR OrthoDB; 2919205at2759; -.
DR Proteomes; UP000189705; Unplaced.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0032968; P:positive regulation of transcription elongation by RNA polymerase II; IEA:InterPro.
DR GO; GO:0006367; P:transcription initiation at RNA polymerase II promoter; IEA:InterPro.
DR CDD; cd00240; TFIIFa; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR008851; TFIIF-alpha.
DR InterPro; IPR011039; TFIIF_interaction.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR13011:SF0; GENERAL TRANSCRIPTION FACTOR IIF SUBUNIT 1; 1.
DR PANTHER; PTHR13011; TFIIF-ALPHA; 1.
DR Pfam; PF05793; TFIIF_alpha; 1.
DR SUPFAM; SSF50916; Rap30/74 interaction domains; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU366044};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU366044};
KW Reference proteome {ECO:0000313|Proteomes:UP000189705};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|RuleBase:RU366044};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW ECO:0000256|RuleBase:RU366044}.
FT REGION 230..507
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 231..263
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 333..352
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 353..367
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 368..392
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 427..452
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 475..502
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 566 AA; 63002 MW; 99A5EE0118F32E85 CRC64;
MEWRLPVCLS AAPGGFEWGL GSVSGAYSVH ARGKVPFPGA QLDTCDPVSA AAMTSLGTSS
QSVTEYVVRV PKTTTKKYNI MAFNAADKVN FASWQQAKME RDLSNKKIYQ EEELPESGAG
SEFNRKLREE ARRKKYGIIL KEFKAEDQPW ILKVNGKAGR KYKGVKKGGV TENASYYIFT
QCPDGAFEAF PVHHWYNFTP VAKHRTLTAE EAEEEWERRN KVLNHFSIMQ QRRLKDQDED
EEEKEKKTKK KGSDLRIHDL EEDLEMSSDE SELSDPDSEK AAKLKKKPAP TKKKKKKKGS
DDEAFEDSDD GDFEGQEVDY MSDASSSSLE EDVGKPKVTK EEDVPKGIDE ASESSEESEE
EKAPEEKEEE EEEKKAPTPQ EKKKKKDSSD ESETSEESDI DSETSSALFM AKKKTPPKKE
RKGSASSSRG NSRPGTPTAD AGSTSSTLRA AANKLEQGKR QGGPGGAPXR TQLDAGGPQP
TSGKSTPQPQ SGKSTPSSGD VQLTEDAVRR YLTRKPMTTK DLLKKFQTKK TGLSSEQTVN
VLAQILKRLN PERKMINDKM HFFLKE
//