ID A0A1U8DCD3_ALLSI Unreviewed; 371 AA.
AC A0A1U8DCD3;
DT 10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT 10-MAY-2017, sequence version 1.
DT 27-MAR-2024, entry version 34.
DE SubName: Full=LIM homeobox transcription factor 1-alpha-like isoform X3 {ECO:0000313|RefSeq:XP_014375385.1, ECO:0000313|RefSeq:XP_014375386.1};
GN Name=LOC102383864 {ECO:0000313|RefSeq:XP_014375385.1,
GN ECO:0000313|RefSeq:XP_014375386.1, ECO:0000313|RefSeq:XP_025059607.1};
OS Alligator sinensis (Chinese alligator).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Crocodylia; Alligatoridae; Alligatorinae;
OC Alligator.
OX NCBI_TaxID=38654 {ECO:0000313|Proteomes:UP000189705, ECO:0000313|RefSeq:XP_025059607.1};
RN [1] {ECO:0000313|RefSeq:XP_014375385.1, ECO:0000313|RefSeq:XP_014375386.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|PROSITE-ProRule:PRU00108, ECO:0000256|RuleBase:RU000682}.
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DR RefSeq; XP_014375384.1; XM_014519898.1.
DR RefSeq; XP_014375385.1; XM_014519899.1.
DR RefSeq; XP_014375386.1; XM_014519900.2.
DR RefSeq; XP_025059607.1; XM_025203822.1.
DR GeneID; 102383864; -.
DR OrthoDB; 932158at2759; -.
DR Proteomes; UP000189705; Unplaced.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd00086; homeodomain; 1.
DR CDD; cd09371; LIM1_Lmx1b; 1.
DR CDD; cd09378; LIM2_Lmx1a_Lmx1b; 1.
DR Gene3D; 2.10.110.10; Cysteine Rich Protein; 2.
DR Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR001781; Znf_LIM.
DR PANTHER; PTHR24208:SF118; LIM HOMEOBOX TRANSCRIPTION FACTOR 1-ALPHA; 1.
DR PANTHER; PTHR24208; LIM/HOMEOBOX PROTEIN LHX; 1.
DR Pfam; PF00046; Homeodomain; 1.
DR Pfam; PF00412; LIM; 2.
DR SMART; SM00389; HOX; 1.
DR SMART; SM00132; LIM; 2.
DR SUPFAM; SSF57716; Glucocorticoid receptor-like (DNA-binding domain); 2.
DR SUPFAM; SSF46689; Homeodomain-like; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
DR PROSITE; PS00478; LIM_DOMAIN_1; 2.
DR PROSITE; PS50023; LIM_DOMAIN_2; 2.
PE 4: Predicted;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW ProRule:PRU00108};
KW Homeobox {ECO:0000256|ARBA:ARBA00023155, ECO:0000256|PROSITE-
KW ProRule:PRU00108};
KW LIM domain {ECO:0000256|ARBA:ARBA00023038, ECO:0000256|PROSITE-
KW ProRule:PRU00125};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723, ECO:0000256|PROSITE-
KW ProRule:PRU00125};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW ProRule:PRU00108}; Reference proteome {ECO:0000313|Proteomes:UP000189705};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|PROSITE-ProRule:PRU00125}.
FT DOMAIN 3..61
FT /note="LIM zinc-binding"
FT /evidence="ECO:0000259|PROSITE:PS50023"
FT DOMAIN 62..124
FT /note="LIM zinc-binding"
FT /evidence="ECO:0000259|PROSITE:PS50023"
FT DOMAIN 167..227
FT /note="Homeobox"
FT /evidence="ECO:0000259|PROSITE:PS50071"
FT DNA_BIND 169..228
FT /note="Homeobox"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00108"
FT REGION 125..190
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 227..279
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 143..169
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 229..259
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 371 AA; 41899 MW; 1080EA687D4CD266 CRC64;
MREVCAGCDT PISDRFLLRV NERSWHEGCV KCTACLQPLS GTCYCRNRQL YCKHDYEKLF
QTKCSSCLKA IAPSEFIMRV LENVYHVHCF YCCECERRLQ RGDEFVLKEG QLLCRSDYEK
EKEMLSAISP APTESGEGAG QGRAVKSEDE DGSHPHGKGG DEGKDHKRSK RPRTILTTQQ
RRAFKASFEV SSKPCRKVRE TLAAETGLTV RVVQVWFQNQ RAKMKKIARR QQQQQQQQQE
QDQLGNPRLG TGRGTGRSSR QSNDDSEDGA SVHGLDGLMV PYPRIPQQQL LPLDQNSYST
DLYRQGLTPP QLPGDHLHPY DSEGVFHDMD SDSIGHLGDC LLSTAEASLL QARVGNPIDR
LYSMQSSYFT S
//
