ID A0A1U8DFZ0_ALLSI Unreviewed; 165 AA.
AC A0A1U8DFZ0;
DT 10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT 10-MAY-2017, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE RecName: Full=Leptin {ECO:0000256|ARBA:ARBA00021421, ECO:0000256|PIRNR:PIRNR001837};
DE AltName: Full=Obesity factor {ECO:0000256|ARBA:ARBA00030981, ECO:0000256|PIRNR:PIRNR001837};
GN Name=LEP {ECO:0000313|RefSeq:XP_014380137.1};
OS Alligator sinensis (Chinese alligator).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Crocodylia; Alligatoridae; Alligatorinae;
OC Alligator.
OX NCBI_TaxID=38654 {ECO:0000313|Proteomes:UP000189705, ECO:0000313|RefSeq:XP_014380137.1};
RN [1] {ECO:0000313|RefSeq:XP_014380137.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Key player in the regulation of energy balance and body
CC weight control. Once released into the circulation, has central and
CC peripheral effects by binding LEPR, found in many tissues, which
CC results in the activation of several major signaling pathways.
CC {ECO:0000256|PIRNR:PIRNR001837}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613,
CC ECO:0000256|PIRNR:PIRNR001837}.
CC -!- SIMILARITY: Belongs to the leptin family.
CC {ECO:0000256|ARBA:ARBA00005834, ECO:0000256|PIRNR:PIRNR001837}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_014380137.1; XM_014524651.2.
DR AlphaFoldDB; A0A1U8DFZ0; -.
DR STRING; 38654.A0A1U8DFZ0; -.
DR GeneID; 102369070; -.
DR KEGG; asn:102369070; -.
DR CTD; 3952; -.
DR eggNOG; ENOG502S5K5; Eukaryota.
DR InParanoid; A0A1U8DFZ0; -.
DR OrthoDB; 5346301at2759; -.
DR Proteomes; UP000189705; Unplaced.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005179; F:hormone activity; IEA:InterPro.
DR Gene3D; 1.20.1250.10; -; 1.
DR InterPro; IPR009079; 4_helix_cytokine-like_core.
DR InterPro; IPR000065; Leptin.
DR PANTHER; PTHR11724; LEPTIN; 1.
DR PANTHER; PTHR11724:SF1; LEPTIN; 1.
DR Pfam; PF02024; Leptin; 1.
DR PIRSF; PIRSF001837; Leptin; 1.
DR PRINTS; PR00495; LEPTIN.
DR SUPFAM; SSF47266; 4-helical cytokines; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|PIRSR:PIRSR001837-1};
KW Reference proteome {ECO:0000313|Proteomes:UP000189705};
KW Secreted {ECO:0000256|PIRNR:PIRNR001837}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 22..165
FT /note="Leptin"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5010544547"
FT DISULFID 118..165
FT /evidence="ECO:0000256|PIRSR:PIRSR001837-1"
SQ SEQUENCE 165 AA; 17747 MW; E613DA08FDCEC9E9 CRC64;
MRCPGLPLCG LLWLGLPLLY GRPVKIDKVK ADAKNLTRTL IARIQELQLL PVNLKVSGLD
FLPGERPLES LEAMDATLQV FQRVLAGLPL DAVPGAQLAN DMENLRSLLR LLGAHLGCAP
PAAPALGNLT DLLAEAPYSA AAVALDRLHK SLHGITKHLD QLRCC
//
