ID A0A1U8DGF8_ALLSI Unreviewed; 755 AA.
AC A0A1U8DGF8;
DT 10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT 10-MAY-2017, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE RecName: Full=peptidylprolyl isomerase {ECO:0000256|ARBA:ARBA00013194};
DE EC=5.2.1.8 {ECO:0000256|ARBA:ARBA00013194};
GN Name=PPIG {ECO:0000313|RefSeq:XP_006025671.1,
GN ECO:0000313|RefSeq:XP_006025673.1, ECO:0000313|RefSeq:XP_014376304.1,
GN ECO:0000313|RefSeq:XP_025062249.1, ECO:0000313|RefSeq:XP_025062251.1};
OS Alligator sinensis (Chinese alligator).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Crocodylia; Alligatoridae; Alligatorinae;
OC Alligator.
OX NCBI_TaxID=38654 {ECO:0000313|Proteomes:UP000189705, ECO:0000313|RefSeq:XP_025062249.1};
RN [1] {ECO:0000313|RefSeq:XP_006025671.1, ECO:0000313|RefSeq:XP_006025673.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=[protein]-peptidylproline (omega=180) = [protein]-
CC peptidylproline (omega=0); Xref=Rhea:RHEA:16237, Rhea:RHEA-
CC COMP:10747, Rhea:RHEA-COMP:10748, ChEBI:CHEBI:83833,
CC ChEBI:CHEBI:83834; EC=5.2.1.8;
CC Evidence={ECO:0000256|ARBA:ARBA00000971};
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DR RefSeq; XP_006025670.1; XM_006025608.2.
DR RefSeq; XP_006025671.1; XM_006025609.3.
DR RefSeq; XP_006025673.1; XM_006025611.3.
DR RefSeq; XP_014376304.1; XM_014520818.2.
DR RefSeq; XP_014376305.1; XM_014520819.1.
DR RefSeq; XP_025062249.1; XM_025206464.1.
DR RefSeq; XP_025062251.1; XM_025206466.1.
DR STRING; 38654.A0A1U8DGF8; -.
DR GeneID; 102381809; -.
DR KEGG; asn:102381809; -.
DR CTD; 9360; -.
DR eggNOG; KOG0546; Eukaryota.
DR OrthoDB; 5324361at2759; -.
DR Proteomes; UP000189705; Unplaced.
DR GO; GO:0003755; F:peptidyl-prolyl cis-trans isomerase activity; IEA:UniProtKB-KW.
DR GO; GO:0006457; P:protein folding; IEA:InterPro.
DR Gene3D; 2.40.100.10; Cyclophilin-like; 1.
DR InterPro; IPR029000; Cyclophilin-like_dom_sf.
DR InterPro; IPR020892; Cyclophilin-type_PPIase_CS.
DR InterPro; IPR002130; Cyclophilin-type_PPIase_dom.
DR PANTHER; PTHR11071; PEPTIDYL-PROLYL CIS-TRANS ISOMERASE; 1.
DR PANTHER; PTHR11071:SF561; PEPTIDYL-PROLYL CIS-TRANS ISOMERASE H; 1.
DR Pfam; PF00160; Pro_isomerase; 1.
DR PRINTS; PR00153; CSAPPISMRASE.
DR SUPFAM; SSF50891; Cyclophilin-like; 1.
DR PROSITE; PS00170; CSA_PPIASE_1; 1.
DR PROSITE; PS50072; CSA_PPIASE_2; 1.
PE 4: Predicted;
KW Isomerase {ECO:0000256|ARBA:ARBA00023235,
KW ECO:0000313|RefSeq:XP_006025671.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000189705};
KW Rotamase {ECO:0000256|ARBA:ARBA00023110}.
FT DOMAIN 11..176
FT /note="PPIase cyclophilin-type"
FT /evidence="ECO:0000259|PROSITE:PS50072"
FT REGION 182..755
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 197..215
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 225..249
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 285..308
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 323..345
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 346..364
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 371..449
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 463..591
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 600..755
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 755 AA; 88435 MW; 18054C29DD2C1BF1 CRC64;
MGVKVQRPRC FFDIAINNVP AGRVVFELFS DVCPKTCENF RCLCTGEKGT GKSTQKPLHY
KSCLFHRVVK DFMIQGGDFS EGNGRGGESI YGGFFEDESF AVKHNKEFLL SMANRGKDTN
GSQFFITTKP TPHLDGHHVV FGQVISGQEV VREIENQKTD ASSKPYAEVR ILSCGELIPK
SKVKKEERKR HKSSSSSSDS DSSSDSDSSS DSSSDSETAS EEKPKKRKKK HKKNSRKHKK
EKKKRKKSKK SSSSESEVEN PEAQPLSTVR PEEIPPVPEN RFLMRKSPPK VDEKDKERKS
REKERESNPA NSQSTYQRRL LVTRSGRKIK GRGPRRYRTP SRSRSRDRFR RSETPPHWRQ
EMQRAQRMRV SSGERWIKGD KSEINENKKD NQKSPGRGKE RKISDHRQAS ESPNRRGEKE
KKIKDHKSSS KDRETRRNSE KDDKYNKSKA KKRAKSRSHS KSREKSKSKE RDSKHNRHEE
KRLRSRSKER EYEKGKEKDK HHDSRGREKE RSRSKERCKR AGSKSNEQDH SKSKDREKYA
KSRSRERDQA KGKYSSNSRT RERSRSRDRG RRARAXXXXS RSKEYSRNRD SRRRGRSRSR
ERRGTPEKYR GRDNRRRRES RSSEREESQS RHRERYSNRE SRSSYRKNDA ENQRKKRSRS
YESSSPETNK EKRGSKDQDS KDQDRSPDSK KRQSSKDREM KTSLSRRSKE KEKSRSSLEK
EINQKSKSQE RDHAHSKDKK SDHESSPGTD EDRHG
//
