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Database: UniProt
Entry: A0A1U8DHX3_ALLSI
LinkDB: A0A1U8DHX3_ALLSI
Original site: A0A1U8DHX3_ALLSI 
ID   A0A1U8DHX3_ALLSI        Unreviewed;      2697 AA.
AC   A0A1U8DHX3;
DT   10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT   10-MAY-2017, sequence version 1.
DT   13-FEB-2019, entry version 12.
DE   SubName: Full=inositol 1,4,5-trisphosphate receptor type 1 isoform X2 {ECO:0000313|RefSeq:XP_014376820.1};
GN   Name=ITPR1 {ECO:0000313|RefSeq:XP_014376820.1};
OS   Alligator sinensis (Chinese alligator).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Crocodylia; Alligatoridae; Alligatorinae;
OC   Alligator.
OX   NCBI_TaxID=38654 {ECO:0000313|Proteomes:UP000189705, ECO:0000313|RefSeq:XP_014376820.1};
RN   [1] {ECO:0000313|RefSeq:XP_014376820.1}
RP   IDENTIFICATION.
RG   RefSeq;
RL   Submitted (DEC-2018) to UniProtKB.
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DR   RefSeq; XP_014376820.1; XM_014521334.1.
DR   GeneID; 102379206; -.
DR   KEGG; asn:102379206; -.
DR   CTD; 3708; -.
DR   KO; K04958; -.
DR   Proteomes; UP000189705; Genome assembly.
DR   GO; GO:0005783; C:endoplasmic reticulum; IEA:InterPro.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0070679; F:inositol 1,4,5 trisphosphate binding; IEA:InterPro.
DR   GO; GO:0005220; F:inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity; IEA:InterPro.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR000493; InsP3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR035910; RyR/IP3R_RIH_dom_sf.
DR   PANTHER; PTHR13715; PTHR13715; 1.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   PRINTS; PR00779; INSP3RECEPTR.
DR   SMART; SM00472; MIR; 4.
DR   SUPFAM; SSF100909; SSF100909; 2.
DR   SUPFAM; SSF48371; SSF48371; 1.
DR   SUPFAM; SSF82109; SSF82109; 2.
DR   PROSITE; PS50919; MIR; 5.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000189705};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Receptor {ECO:0000313|RefSeq:XP_014376820.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000189705};
KW   Repeat {ECO:0000256|SAAS:SAAS00903904};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2219   2241       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2253   2271       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2277   2304       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2340   2365       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2385   2407       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2518   2541       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      112    166       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      173    223       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      231    287       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      294    358       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      364    420       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   COILED     1578   1598       {ECO:0000256|SAM:Coils}.
FT   COILED     2635   2676       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   2697 AA;  307603 MW;  4BF874F5A3EDECCA CRC64;
     MTDKMSSFLH IGDICSLYAE GSTNGFISTL GLVDDRCVVQ PDAGDLNNPP KKFRDCLFKL
     CPMNRYSAQK QFWKAAKPGA NSTTDAVLLN KLHHAADLEK KQNETENRKL LGTVIQYGNV
     IQLLHLKSNK YLTVNKRLPA LLEKNAMRVT LDEAGNEGSW FYIQPFYKLR SIGDSVVIGD
     KVVLNPVNAG QPLHASSHQL VDNPGCNEVN SVNCTTSWKI VLFMKWSDNK DDILKGGDVV
     RLFHAEQEKF LTCDEHRKKQ HVFLRTTGRQ SATSATSSKA LWEVEVVQHD PCRGGAGYWN
     SLFRFKHLAT GHYLAAELDP DQDGSQQGLH NAQEKMAYSL VSVPEGNDIS SIFELDPTTL
     RGGDSLVPRN SYVRLRHLCT NTWVHSTNIP IDKEEEKPVM LKIGTSPVKE DKEAFAIVPV
     SPAEVRDLDF ANDASKVLGS IAGKLEKGTI TQNERRSVTK LLEDLVYFVT GGTNSGQDVL
     EVVFSKPNRE RQKLMREQNI LKQIFKLLQA PFTDSGDGPM LRLEELGDQR HAPFRHICRL
     CYRVLRHSQQ DYRKNQEYIA KQFGFMQKQI GYDVLAEDTI TALLHNNRKL LEKHITAAEI
     DTFVSLVRKN REPRFLDYLS DLCVSMNKSI PVTQELICKA VLNPANADIL IETKLVLSRF
     EFEEVSSGDN ALEVGEDEEE VWLFWRDSNQ EIRSKSIREL AQDAKEGQKE DRDVLSYYRY
     QLNLFARMCL DRQYLAINEI SGQLDVDLIL RCMSDENLPY DLRASFCRLM LHMHVDRDPQ
     EQVTPVKYAR LWSEIPSEIA IDDYDSSGTS KDEIKERFAQ TMEFVEEYLR DVVCQRFPFS
     DKEKNKLTFE VVNLARNLIY FGFYNFCDLL RLTKILLAIL DCVHITTIFP ITKMAKGEEN
     KGSNVMRSIH GVGELMTQVV LRGGGFLPIA PLAAAPEGNV KQSEPEKEDI LVMDTKLKII
     EILQFILNVR LDYRISCLLC IFKREFDESN AQMSESPTGS SSPDVPTNVP GALDFEHIEE
     QAEGIFGGSE ENTPLDLDDH GGRTFLRVLL HLTMHDYPPL VSGALQLLFR HFSQRQEVLQ
     AFKQVQLLVT SQDVDNYKQI KQDLDQLRSI VEKSELWVYK GQSPDETMDG AQGENEHKKK
     EEGHGKPQKY ESTSSYNYRV MKEILLRLSK LCVQESISVR KNRKQQQRLL RNMGAHTVVL
     ELLQIPYEKA EDTRMQEIMK LAHEFLQNFC AGNQQNQALL HKHINLFLNP GILEAVTMQH
     IFMNNFQLCS EINERVVQHF VHCIETHGRN VQYIKFLQTI VKAEGKFIKK CQDMVMAELV
     NAGEDVLVFY NDRASFQTLV QMMRSERDRM DENSPLMYHI HLVELLAVCT EGKNVYTEIK
     CNSLLPLDDI VRVVTHEDCI PEVKIAYINF LNHCYVDTEV EMKEIYTSNH MWKLFESFLV
     DICRACNNTS DRKHTDSILE KYVTEIVMSI VTTFFSSPFS DQSTTLQTRQ PVFVQLLQGV
     FRVYHCNWLM PSQKASVESC IRVLSDVAKS RAIAIPVDLD SQVNNLFLKS HNIVQKTAMN
     WRMTARNAAR RDSVLAASRD YRNIIERLQD IVSALEDRLR PLVQAELSVL VDVLHRPELL
     FPENTDARRK CESGGFICKL IKHTKQLLEE NEEKLCIKVL QTLREMMTKD RGYGEKGEAL
     RQLLVNRYYG NVRPAGRRES LTSFGNGPLS AGGASKAGGG GGSSVSSSMN RGEMSLTDVQ
     CHLDKEGASN LVIDLIMNAT SDRVFHESIL LAIALLEGGN TTIQHSFFCR LTEDKKSEKF
     FKVFYDRMKV AQQEIKATVT VNTSDLGNKK KDEDTDRDVP VRKRVREPMT QITEEVRDQL
     LEASNATRKA YNTYRREADP DDHFSPGDGA QSAADKNRDE LEMSAVITIM QPILRFLQLL
     CENHNRDLQN FLRCQNNKTN YNLVCETLQF LDCICGSTTG GLGLLGLYIN EKNVALINQT
     LESLTEYCQG PCHENQNCIA THESNGIDII TALILNDINP LGKKRMDLVL ELKNNASKLL
     LAIMESRHDS ENAERILYNM RPKELVEVIK KAYMQGEVEF EDGENGEDLA ASPRNVGHNI
     YILAHQLARH NKELQNMLKP GGQVEGDEAL EFYAKHTAQI EIVRLDRTME QIVFPVPSIC
     EFLTKESKLR IYYTTERDEQ GSKINDFFMK SEDLFNEMNW QKKLRAQPVL YWCARNMSFW
     SSISFNLAVL MNLLVAFFYP FEGVREDTLE THLSVLLWTA MLISLAIVIA LPKPHGIRAL
     IASTILRLIF SVGLQPTLFL LGAFNVCNKT IFVMSFVGNC GTFTRGYKAM ILDVEFLYHL
     LYLLICAMGL FVHEFFYSLL LFDLVYREET LLNVIKSVTR NGRSIILTAV LALILVYLFS
     IVGYLFFKDD FILEVDKLPN ETLLPDRTDS GETMTGEFLY SDVCKAGSGE NCSSVIPSKE
     LISEENEEEN KEHTCETLLM CIVTVLSHGL RSGGGVGDVL RKPSKEEPLF AARVIYDLLF
     FFMVIIIVLN LIFGVIIDTF ADLRSEKQKK EEILKTTCFI CGLERDKFDN KTVTFEEHIK
     EEHNMWHYLC FIVLVKVKDS TEYTGPESYV AEMIKERNLD WFPRMRAMSL VSSDSEGEQN
     ELRNLQEKLE STMKLVTNLS GQLSELKDQM TEQRKQKQRI GLLGHPPPMN VNPQQPA
//
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