ID A0A1U8DK66_ALLSI Unreviewed; 1675 AA.
AC A0A1U8DK66;
DT 10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 2.
DT 27-MAR-2024, entry version 31.
DE RecName: Full=ubiquitinyl hydrolase 1 {ECO:0000256|ARBA:ARBA00012759};
DE EC=3.4.19.12 {ECO:0000256|ARBA:ARBA00012759};
GN Name=USP32 {ECO:0000313|RefSeq:XP_014378124.2};
OS Alligator sinensis (Chinese alligator).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Crocodylia; Alligatoridae; Alligatorinae;
OC Alligator.
OX NCBI_TaxID=38654 {ECO:0000313|Proteomes:UP000189705, ECO:0000313|RefSeq:XP_014378124.2};
RN [1] {ECO:0000313|RefSeq:XP_014378124.2}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Thiol-dependent hydrolysis of ester, thioester, amide, peptide
CC and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-
CC residue protein attached to proteins as an intracellular targeting
CC signal).; EC=3.4.19.12; Evidence={ECO:0000256|ARBA:ARBA00000707};
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DR RefSeq; XP_014378124.2; XM_014522638.2.
DR STRING; 38654.A0A1U8DK66; -.
DR KEGG; asn:102384323; -.
DR eggNOG; KOG0044; Eukaryota.
DR eggNOG; KOG1870; Eukaryota.
DR InParanoid; A0A1U8DK66; -.
DR OrthoDB; 5474185at2759; -.
DR Proteomes; UP000189705; Unplaced.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0004843; F:cysteine-type deubiquitinase activity; IEA:UniProtKB-EC.
DR CDD; cd00051; EFh; 1.
DR Gene3D; 3.90.70.10; Cysteine proteinases; 3.
DR Gene3D; 3.30.2230.10; DUSP-like; 1.
DR Gene3D; 1.10.238.10; EF-hand; 2.
DR InterPro; IPR035927; DUSP-like_sf.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR InterPro; IPR006615; Pept_C19_DUSP.
DR InterPro; IPR001394; Peptidase_C19_UCH.
DR InterPro; IPR028135; Ub_USP-typ.
DR InterPro; IPR018200; USP_CS.
DR InterPro; IPR028889; USP_dom.
DR PANTHER; PTHR21646; UBIQUITIN CARBOXYL-TERMINAL HYDROLASE; 1.
DR PANTHER; PTHR21646:SF76; UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 32; 1.
DR Pfam; PF06337; DUSP; 1.
DR Pfam; PF13202; EF-hand_5; 2.
DR Pfam; PF14836; Ubiquitin_3; 1.
DR Pfam; PF00443; UCH; 1.
DR PRINTS; PR00450; RECOVERIN.
DR SMART; SM00695; DUSP; 1.
DR SMART; SM00054; EFh; 2.
DR SUPFAM; SSF54001; Cysteine proteinases; 1.
DR SUPFAM; SSF143791; DUSP-like; 1.
DR SUPFAM; SSF47473; EF-hand; 2.
DR PROSITE; PS51283; DUSP; 1.
DR PROSITE; PS00018; EF_HAND_1; 2.
DR PROSITE; PS50222; EF_HAND_2; 2.
DR PROSITE; PS00972; USP_1; 1.
DR PROSITE; PS00973; USP_2; 1.
DR PROSITE; PS50235; USP_3; 1.
PE 4: Predicted;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Hydrolase {ECO:0000313|RefSeq:XP_014378124.2};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000189705}.
FT DOMAIN 280..315
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT DOMAIN 316..351
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT DOMAIN 421..637
FT /note="DUSP"
FT /evidence="ECO:0000259|PROSITE:PS51283"
FT DOMAIN 800..1638
FT /note="USP"
FT /evidence="ECO:0000259|PROSITE:PS50235"
FT REGION 1410..1514
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1426..1469
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1491..1505
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1675 AA; 189833 MW; 1D0F30FF45C40B3A CRC64;
MTTITGAISV ASVPRVRVQP AFLQERVIRS GKRRFRAMKT PFLRIILGWC NHSGSSRLRI
MSLAYTRSKF ALTDVELKRL KDAFKRTCGL SCYMSQQCFI REVLGDGVPP KVAEVIYCSF
GGTAKGLHFN NLIVGLVLLT RGKEEEKAKY IFSLFSNESG SYVVREEMER MLHVVDGKVP
DTLKKCFSEG EKVNYEKFKN WLLHNKDAFT FSRWLLSGGV YVTLTDDSDT PTFYQTLAGV
THLEESDIID LEKRYWLLKA QSRTGRFDLE TFGPLVSPPI HPSLSEGLFN AFDENRDNHI
DFKEISCGLS ACCRGPLAER QKFCFKVFDV DRDGVLSRTE LKEMVVALLE VWKDNRTDKI
PELDKDLSEI VEDILNAHDT TKIGHLTLED YQIWSVKSAL ANEFLNLLFQ VCHIVLGLRP
ATPEEEGQII RGWLERESRY GLQPGHNWFL IAVSWWQQWK EYVKYDANLV MIESSFVLNG
GKNAVIAAST HASEQGEEKM GGLNYFSATE EKISDNISTA SEASETTSSN TLYSIAPGTD
MCFARQHNTS DNNNQCLLVS NGNTLLQLNP QKPGAIDNQP LVTQEPVKAA SLTMEGGRLK
QSPHLVEGRD YIMVPEPVWR ALYHWYGANL SLPRPVIKNS KTNMPELELF PCYLLFLRQQ
PATRTQQSNI WVNMGMMSLR VFPQHLPRGN VPSPNAPLKR VLAYTGCFSR MQTIKEIHEY
LSQRLRIKEE DMRLWIYYSE NHLSLLDDED HRLEYLKIKD EQHLVIEVRN KDMSWPEEMS
FIANSSKIDR HKVPTEKGAT GLSNLGNTCF MNSSIQCVSN TQPLTQYFIS GRHLYELNRT
NPIGMKGHMA KCYGDLVQEL WSGTQKNIAP LKLRWTIAKY APRFNGFQQQ DSQELLAFLL
DGLHEDLNRV HDKPYVELKD SDGRPDWEVA AEAWENHLRR NRSIVVDLFH GQLKSQVKCK
TCGHISVRFD PFNFLSLPLP MDSYMHLEIT VIKLDGTTPV RYGLRLNMDE KYTGLKKQLS
ELCGLKPEQI LLAEVHGSNI KNFPQDNQKV RLSVSGFLCA FEIPVPGSPT SASSPVQTDF
STGPSTNGML NIMMNGDLPR PTLIPNGMPN TVVPCGTENN LANWTLNGHV SLLPDSPFIG
YIIAVHRKMM RTELYFLSSQ KNRPSLFGMP LIVPCTVHTR KKDLYDAVWI QVSRLASPLP
PQEASNHAQD CDDSMGYQYP FTLRVVQKDG NSCAWCPWYR FCRGCKIECT EDRACVGNAY
IAVDWDPTAL HLRYQTSQER IVEEHESVEQ SRRAQAEPIN LDSCLRAFTS EEELGEDEMY
YCSKCKTHCL ATKKLDLWRL PPILIIHLKR FQFVNGRWIK SQKIVKFPRE NFDPSAFLVQ
KDPSLCQRKQ LTPQVDDLCE PRILQGESRK ADLQNTCPAG EGDVLNRSPS SLNTTSILNN
IKASPSPGRR SGTSCPSSKT SSPNSSPRTL GRGKGRLRLP QLGKNKLSSS KENLDASKDN
GTDPEQKFTS DQGDAFSRGH ILGGSQNELF AAQDNEVTVA NGYFCEQNAY SNGSINGQMD
NHSEEDITDD QREEVGVNPI YNLYAISCHS GIMGGGHYVT YAKNPNNKWY CYNDSSCKEL
HPDEIDTDSA YILFYEQQGV DYAQFLPKID GKKMADTSSM DEDFESDYKK YCVLQ
//
