ID A0A1U8DKB6_ALLSI Unreviewed; 756 AA.
AC A0A1U8DKB6;
DT 10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT 10-MAY-2017, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=Cullin-2 isoform X1 {ECO:0000313|RefSeq:XP_014381693.1};
GN Name=CUL2 {ECO:0000313|RefSeq:XP_014381693.1};
OS Alligator sinensis (Chinese alligator).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Crocodylia; Alligatoridae; Alligatorinae;
OC Alligator.
OX NCBI_TaxID=38654 {ECO:0000313|Proteomes:UP000189705, ECO:0000313|RefSeq:XP_014381693.1};
RN [1] {ECO:0000313|RefSeq:XP_014381693.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC {ECO:0000256|ARBA:ARBA00004906}.
CC -!- SIMILARITY: Belongs to the cullin family.
CC {ECO:0000256|ARBA:ARBA00006019, ECO:0000256|PROSITE-ProRule:PRU00330,
CC ECO:0000256|RuleBase:RU003829}.
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DR RefSeq; XP_014381693.1; XM_014526207.2.
DR AlphaFoldDB; A0A1U8DKB6; -.
DR STRING; 38654.A0A1U8DKB6; -.
DR GeneID; 102374109; -.
DR CTD; 8453; -.
DR InParanoid; A0A1U8DKB6; -.
DR OrthoDB; 5474206at2759; -.
DR UniPathway; UPA00143; -.
DR Proteomes; UP000189705; Unplaced.
DR GO; GO:0031461; C:cullin-RING ubiquitin ligase complex; IEA:InterPro.
DR GO; GO:0031625; F:ubiquitin protein ligase binding; IEA:InterPro.
DR GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR GO; GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:InterPro.
DR Gene3D; 1.20.1310.10; Cullin Repeats; 4.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR045093; Cullin.
DR InterPro; IPR016157; Cullin_CS.
DR InterPro; IPR016158; Cullin_homology.
DR InterPro; IPR036317; Cullin_homology_sf.
DR InterPro; IPR001373; Cullin_N.
DR InterPro; IPR019559; Cullin_neddylation_domain.
DR InterPro; IPR016159; Cullin_repeat-like_dom_sf.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR11932; CULLIN; 1.
DR PANTHER; PTHR11932:SF177; CULLIN-2; 1.
DR Pfam; PF00888; Cullin; 1.
DR Pfam; PF10557; Cullin_Nedd8; 1.
DR SMART; SM00182; CULLIN; 1.
DR SMART; SM00884; Cullin_Nedd8; 1.
DR SUPFAM; SSF75632; Cullin homology domain; 1.
DR SUPFAM; SSF74788; Cullin repeat-like; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS01256; CULLIN_1; 1.
DR PROSITE; PS50069; CULLIN_2; 1.
PE 3: Inferred from homology;
KW Isopeptide bond {ECO:0000256|ARBA:ARBA00022499};
KW Reference proteome {ECO:0000313|Proteomes:UP000189705};
KW Ubl conjugation {ECO:0000256|ARBA:ARBA00022843}.
FT DOMAIN 402..629
FT /note="Cullin family profile"
FT /evidence="ECO:0000259|PROSITE:PS50069"
SQ SEQUENCE 756 AA; 88322 MW; FB8DC6FBC0BC7396 CRC64;
MSLKPRVVDF DETWNKLLTT IKAVVMLDYV ERATWNDRFS DIYALCVAYP EPLGERLYTE
TKIFLENHVH LLHKRVLDSE EQVLVMYHRY WEEYSQGADY MDCLYRYLNT QFIKKNKLTE
ADLQYGYGGV DMNEPLMEIG ELALDMWRKL MIEPLQAILI RMLLREIKND RCGEDPNQKV
IHGVINSFVH VEQYKKKFPL KFYQEIFECP FLNETGEYYK QEASNLLQES NCSQYMEKVL
GRLKDEEMRC RKYLHPSSYG KVIHECQQRM VADHLQFLHA ECHNIIRQEK RSDMANMYTL
LRAVSSGLPH MIQELQNHIH DEGLRATSNL SQENMPTQFV ESVLEVHSKF VQLINTVLNG
DQHFMSALDK ALTSVVNYRE PKSICKAPEL VLGLFSFFLL ELAKYCDNLL KKSAKGMTEN
EVEDKLTSFI TVFKYIDDKD VFQKFYARML AKRLIHGLSM SMDSEEAMIN KLKQACGYEF
TSKLHRMYTD MSVSADLNNK FNNFIKNQDT IIDLGISFQI YVLQAGAWPL TQAPSSTFAI
PQELEKSVQM FELFYSQHFS GRKLTWLHYL CTGEVKMNYL CKPYVAMVTT YQMAVLLAFN
NSETVSYKEL QDSTQMNEKE LTKTIKSLLD VKMINHDSDK EDIEAESTFS LNMNFSSKRT
KFKITTSMQK DTPQEMEQTR SAVDEDRKMY LQAAIVRIMK ARKVLRHNAL IQEVISQSRA
RFNPSISMIK KCIEVLIDKQ YIERSQASAD EYSYVA
//
