ID A0A1U8DN44_ALLSI Unreviewed; 2104 AA.
AC A0A1U8DN44;
DT 10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT 10-MAY-2017, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE SubName: Full=Dysferlin isoform X3 {ECO:0000313|RefSeq:XP_014379144.1};
GN Name=DYSF {ECO:0000313|RefSeq:XP_014379144.1};
OS Alligator sinensis (Chinese alligator).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Crocodylia; Alligatoridae; Alligatorinae;
OC Alligator.
OX NCBI_TaxID=38654 {ECO:0000313|Proteomes:UP000189705, ECO:0000313|RefSeq:XP_014379144.1};
RN [1] {ECO:0000313|RefSeq:XP_014379144.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle membrane
CC {ECO:0000256|ARBA:ARBA00004483}; Single-pass type II membrane protein
CC {ECO:0000256|ARBA:ARBA00004483}. Membrane
CC {ECO:0000256|ARBA:ARBA00004606}; Single-pass type II membrane protein
CC {ECO:0000256|ARBA:ARBA00004606}.
CC -!- SIMILARITY: Belongs to the ferlin family.
CC {ECO:0000256|ARBA:ARBA00007561}.
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DR RefSeq; XP_014379144.1; XM_014523658.2.
DR GeneID; 102387112; -.
DR KEGG; asn:102387112; -.
DR CTD; 8291; -.
DR eggNOG; KOG1326; Eukaryota.
DR OrthoDB; 991411at2759; -.
DR Proteomes; UP000189705; Unplaced.
DR GO; GO:0030659; C:cytoplasmic vesicle membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd08373; C2A_Ferlin; 1.
DR CDD; cd04011; C2B_Ferlin; 1.
DR CDD; cd04018; C2C_Ferlin; 1.
DR CDD; cd04017; C2D_Ferlin; 1.
DR CDD; cd04037; C2E_Ferlin; 1.
DR CDD; cd08374; C2F_Ferlin; 1.
DR Gene3D; 2.60.40.150; C2 domain; 6.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR037726; C2A_Ferlin.
DR InterPro; IPR037720; C2B_Ferlin.
DR InterPro; IPR037722; C2C_Ferlin.
DR InterPro; IPR037723; C2D_Ferlin.
DR InterPro; IPR037724; C2E_Ferlin.
DR InterPro; IPR037725; C2F_Ferlin.
DR InterPro; IPR012968; FerIin_dom.
DR InterPro; IPR037721; Ferlin.
DR InterPro; IPR012560; Ferlin_A-domain.
DR InterPro; IPR012561; Ferlin_B-domain.
DR InterPro; IPR032362; Ferlin_C.
DR InterPro; IPR006614; Peroxin/Ferlin.
DR PANTHER; PTHR12546; FER-1-LIKE; 1.
DR PANTHER; PTHR12546:SF33; SPERM VESICLE FUSION PROTEIN FER-1; 1.
DR Pfam; PF00168; C2; 7.
DR Pfam; PF08165; FerA; 1.
DR Pfam; PF08150; FerB; 1.
DR Pfam; PF08151; FerI; 1.
DR Pfam; PF16165; Ferlin_C; 1.
DR SMART; SM00239; C2; 7.
DR SMART; SM00694; DysFC; 2.
DR SMART; SM00693; DysFN; 2.
DR SMART; SM01200; FerA; 1.
DR SMART; SM01201; FerB; 1.
DR SMART; SM01202; FerI; 1.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 7.
DR PROSITE; PS50004; C2; 7.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Cytoplasmic vesicle {ECO:0000256|ARBA:ARBA00023329};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000189705};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal-anchor {ECO:0000256|ARBA:ARBA00022968};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 2069..2091
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1..101
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 191..318
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 357..493
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 1133..1259
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 1307..1435
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 1578..1696
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 1812..1967
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT REGION 128..215
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2022..2041
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 128..143
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 152..168
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 194..208
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2104 AA; 240074 MW; 1A39D90DAA74CCE9 CRC64;
MLRVFVLRAE AVQTPDTDIS DAYCSVLFAG VKKRTKVIKN NVNPVWNEGF EWDLKGVPLD
QSCELSVIVK DHETMGRNRF LGEAHVPLRD VLASPSLAAS FNVPLLDTKK QSTGAFLVLQ
VSYIPPPGAA PLFPPPVPPE PTPTAAEQDT FTDTAGEEDT EDLIVTGDEE EPSSGPSVPS
VPEQPTLPKK PPGHHVQGLK RRRSSSKKPL SNKPQDFQIR VRVIEGRQLP GVNIKPVVKV
TAAGQSKRTR ICKGNGPVFD ETFFFNIFEA PSELFDEHIF LTVVDSRSFR TDSVIGEFRM
DVGTVYAEPK HAFLRKWLLL SDPEDFSAGA KGYLKVSLFV LGSGDEAPLE KKEKAEDKED
IEGNILRPTG VALRGAHFSL KVYRAEDLPQ MDDAVMDNVK QIFGFESNKK NLVDPFVEVS
FAGKMLCSKI LEKNANPQWN QSITLPAMFP SMCEKMRIRV TDWDRMTHND IVGTTYLSMS
KISAPGGELE DEFPVVAKPL KAADLDDSLG FLPTFGPCYV NLYGSPREFT GFPDPYEELN
LGKGEGVAYR GRLLVELETK LVEHIEQKVE DIPADDILRV EKFLRRRKYS LFAAFYSATM
LQDVNDPIQF EVSIGNYGNK FDNTCLPLAS TTQYSRAVFD GCQYYYLPWG NVKPVVVLSS
YWEDISHRTD VQNTLQRCVD RLEANLEQVH IMLKAKCSPR DLDASVARLI DDIIADCSQP
LTDVMGKPAC THLDQYAYRF RSTNLNQIVQ AALKLKHEDT DLQTVLEQAE DWLLRLKAMA
EEPQNSLPDI VIWMLRGDRR VAYARVPAHE VLFSRSSASC CGKNCGKLQT IFLKYPQEEV
MGIRIPAQVR VQLWFGMSVD EKEFNPYAEG RLSVFAETYE NQTKLALVGN WGTTGLTYPK
YTDVTGKIKL PKDSFRPSAG WAWAGDWFIS PEKTLLYDTD AGHMSFVEEV FENQVRLPGG
QWIHMAEAYT DVNGEKVLPK DEIECPPGWK WEDSEWDTDL NRAVDERGWE YGITIPPDCK
PKSWVPAEKM YHTNRRRRWV RLRRRDLMQT EALKKHKQEE LEGEGWEYAS LFGWRFHLKY
RKTDAFRRRR WRRRMEPLER TGPAVVFALE GALGGVTDDK SDDGKSVSTL SFGVNRPTIS
CIFDYGNKYH LRCYMYQARD LIALDKDSFS DPYAIVSFLQ QSQKTVVVKN TLNPTWDQTL
IFYEIEIFGD PQNVADSPPN IVVELYDHDT YGADEFMGRC ICRPSLERCP RLSWHPITKG
NRNTGELLAA FELIQREKPA VHHIPGFESE LSADSLDESA DTDLPYPPPQ REPNVYMVPQ
GIKPVLQRTA IEILAWGLRR LKSYQLASIT SPSLVVECGG QSVQSCVIKN IKKNPNFDVS
VLFMEVRLPK EDLYSPPIII KVIDNRPFGR KPVVGQCTIR SLEDFYCDPY SKETIVPEEH
SDDVSLTPRD DVLIDIDDKE PLIPVQLAEG MTSSALINMT ASRSDLHEEE FIDWWSKFYA
STGEREKCGS YLEKGFDTLK VYETELEKVE GFERLSDFCH TFKLYRGRMQ DANEDPTIVG
EFKGSFKLYP LPDDPRVPVP PRQFHQLPAR GPQECLVRVY IIRAFDLQPK DTNGKCDPYV
KISAGKKSIN DQDNYIPCTL EPVFGKMFEL TCSLPLEKDL KITLYDYDLL SKDEKIGETV
IDLENRFLSK YGARCGLPQT YCTSGPNQWR DQLRPSQLLH LFSLQRNCKA PVYKTDRVVF
GEQEYFLVEL EDGKPPNPHL GSPEERLALH ALRKQGLVPE HVETRPLYSP LQPEIEQGKL
QMWVDLFPKS LGAPGPPFNI TPRKAKRFFL RCIIWNTKDV ILDDLSITGE KMSDIYVKGW
LVGHEESKQK TDVHYRSLGG EGNFNWRFVX XXXXXXXXXX YQPAEQVWYV TKKEHFWSLD
KTESKIPPQL TFQIWDNDKF SFDDYLGCIQ MDLNHMPKPA KTAEKCSLDL LDETLSSDRL
VSLFEQKTVK GWWPCVAEEG EKKILAGKLE MTLEIVAEQE HEERPAGMGR DEPNMNPKLE
DPKRPETSFL WFTSPYKTIK YILWRRYKWV FLVLLVLFIL LLFLGIFIYA FPNYAAMKLV
KPFS
//
