ID A0A1U8DQ65_ALLSI Unreviewed; 1075 AA.
AC A0A1U8DQ65;
DT 10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT 10-MAY-2017, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE SubName: Full=Protein transport protein Sec24A isoform X3 {ECO:0000313|RefSeq:XP_014383343.1};
GN Name=SEC24A {ECO:0000313|RefSeq:XP_014383343.1};
OS Alligator sinensis (Chinese alligator).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Crocodylia; Alligatoridae; Alligatorinae;
OC Alligator.
OX NCBI_TaxID=38654 {ECO:0000313|Proteomes:UP000189705, ECO:0000313|RefSeq:XP_014383343.1};
RN [1] {ECO:0000313|RefSeq:XP_014383343.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol
CC {ECO:0000256|ARBA:ARBA00004514}. Cytoplasmic vesicle, COPII-coated
CC vesicle membrane {ECO:0000256|ARBA:ARBA00004299}; Peripheral membrane
CC protein {ECO:0000256|ARBA:ARBA00004299}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004299}. Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004397}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004397}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004397}. Membrane
CC {ECO:0000256|ARBA:ARBA00004287}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004287}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004287}.
CC -!- SIMILARITY: Belongs to the SEC23/SEC24 family. SEC24 subfamily.
CC {ECO:0000256|ARBA:ARBA00008334}.
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DR RefSeq; XP_014383343.1; XM_014527857.2.
DR AlphaFoldDB; A0A1U8DQ65; -.
DR GeneID; 102380792; -.
DR CTD; 10802; -.
DR OrthoDB; 977017at2759; -.
DR Proteomes; UP000189705; Unplaced.
DR GO; GO:0030127; C:COPII vesicle coat; IEA:InterPro.
DR GO; GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0006888; P:endoplasmic reticulum to Golgi vesicle-mediated transport; IEA:InterPro.
DR GO; GO:0006886; P:intracellular protein transport; IEA:InterPro.
DR CDD; cd01479; Sec24-like; 1.
DR Gene3D; 2.60.40.1670; beta-sandwich domain of Sec23/24; 1.
DR Gene3D; 1.20.120.730; Sec23/Sec24 helical domain; 1.
DR Gene3D; 3.40.20.10; Severin; 1.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR Gene3D; 2.30.30.380; Zn-finger domain of Sec23/24; 1.
DR InterPro; IPR029006; ADF-H/Gelsolin-like_dom_sf.
DR InterPro; IPR007123; Gelsolin-like_dom.
DR InterPro; IPR036180; Gelsolin-like_dom_sf.
DR InterPro; IPR006900; Sec23/24_helical_dom.
DR InterPro; IPR036175; Sec23/24_helical_dom_sf.
DR InterPro; IPR006896; Sec23/24_trunk_dom.
DR InterPro; IPR012990; Sec23_24_beta_S.
DR InterPro; IPR041742; Sec24-like_trunk_dom.
DR InterPro; IPR036465; vWFA_dom_sf.
DR InterPro; IPR006895; Znf_Sec23_Sec24.
DR InterPro; IPR036174; Znf_Sec23_Sec24_sf.
DR PANTHER; PTHR13803:SF1; PROTEIN TRANSPORT PROTEIN SEC24A; 1.
DR PANTHER; PTHR13803; SEC24-RELATED PROTEIN; 1.
DR Pfam; PF00626; Gelsolin; 1.
DR Pfam; PF08033; Sec23_BS; 1.
DR Pfam; PF04815; Sec23_helical; 1.
DR Pfam; PF04811; Sec23_trunk; 1.
DR Pfam; PF04810; zf-Sec23_Sec24; 1.
DR SUPFAM; SSF81995; beta-sandwich domain of Sec23/24; 1.
DR SUPFAM; SSF82754; C-terminal, gelsolin-like domain of Sec23/24; 1.
DR SUPFAM; SSF81811; Helical domain of Sec23/24; 1.
DR SUPFAM; SSF53300; vWA-like; 1.
DR SUPFAM; SSF82919; Zn-finger domain of Sec23/24; 1.
PE 3: Inferred from homology;
KW Cytoplasmic vesicle {ECO:0000256|ARBA:ARBA00023329};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW Reference proteome {ECO:0000313|Proteomes:UP000189705};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT DOMAIN 410..446
FT /note="Zinc finger Sec23/Sec24-type"
FT /evidence="ECO:0000259|Pfam:PF04810"
FT DOMAIN 483..721
FT /note="Sec23/Sec24 trunk"
FT /evidence="ECO:0000259|Pfam:PF04811"
FT DOMAIN 726..810
FT /note="Sec23/Sec24 beta-sandwich"
FT /evidence="ECO:0000259|Pfam:PF08033"
FT DOMAIN 821..921
FT /note="Sec23/Sec24 helical"
FT /evidence="ECO:0000259|Pfam:PF04815"
FT DOMAIN 947..1015
FT /note="Gelsolin-like"
FT /evidence="ECO:0000259|Pfam:PF00626"
FT REGION 1..269
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 14..38
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 58..79
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 92..178
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 187..226
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 232..269
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1075 AA; 117930 MW; 4AA357E4D8984880 CRC64;
MAQPGRAHGA GQQAYSNGPV QNPLMHSSHV SDGQRYNSPG LYSHPIPTKP PLHPSPGQYN
YGGSQNVSQL SNYQGPGQTL NRAPVGPISA APLQHTGSSP QMPPPSQNSA AISSAGSFLP
GTNPPALSNW QYGQTTVSQP AGSQTSHFAH VTGAVPTQPS ASSPSSLGNT NPPTSYQYAA
SPGVPPLPNS YMKPGSAPPP VSQPLPSTYP PARPPLGPPP SGGPPLGRPT AAMTSPPNSS
VSQALLNSAT NQEASTHPSP ASQNLKMGRS VGYSYPSLPP GYQNTSPGVP GMQPPPMQYP
DGPQSFHQPA LGTNHLAASM GSLSLQPEGV RLVNLLQERN ILPTAPLQAP IPNLHEDIQK
LNCNPELFRC TLTNIPQTQA LLNKAKLPLG LLLHPFKDLS QLPVVTSSTI VRCRSCRTYI
NPFVSFLDQR RWKCNLCYRV NDVPEEFMYN PVTRVYGEPH KRPEVQNATI EFMAPSEYML
RPPQPPVYLF VFDVSHNAIE TGYLDTVCKS LLDNLDLLPG NTRTKIGFIT FDSTIHFYSL
QEGLSQPQML IVSDIEDVFI PMPENLLVNL NENKELIQDL LRTLPQMFTK SLETQSALGP
ALQAAFKLMS PTGGRISVFQ TQLPSVGVGA LKSREEPNQR ASAKDIHLTP STDFYKKLAL
DCSGQQVAVD LFLLSGQYSD LASLGCISRY SAGSIYYYQS YHHKHNPVQV EKLQKELKRY
LTRKIGFEAV MRIRCTKGLS IHTFHGNFFV RSTDLLSLPN VNPDAGYAVQ MSVEESLTDM
QVVSFQSALL YTSSKGERRI RVHTMCLPVV TTLNDVYLGA DVQAITGLLA NMAVDRSVSA
SLSDARDALV NAVIDSLSAY RSSVLSVQQP GLMAPFSLRL FPLYVLALLK QKAFQTGTTT
RLDERIFTMC QVKNQPLIYL MLMTHPSLYR IDNLTDEGAL NINDRTIPQP PILQLSAEKL
SRDGAYLMDA GSVMFMWIGK NCGQNFINQV FGVPNYASIP QNMTHLPELD TAESTRILAF
ISWLREQRPF FPILYIIRDE SPLKPSFLQN MIEDRTESAL SYYEFLLHIQ QQVNK
//
