ID A0A1U8DVE6_ALLSI Unreviewed; 814 AA.
AC A0A1U8DVE6;
DT 10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT 10-MAY-2017, sequence version 1.
DT 27-MAR-2024, entry version 37.
DE SubName: Full=Probable G-protein coupled receptor 156 isoform X1 {ECO:0000313|RefSeq:XP_025048606.1};
GN Name=GPR156 {ECO:0000313|RefSeq:XP_025048606.1};
OS Alligator sinensis (Chinese alligator).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Crocodylia; Alligatoridae; Alligatorinae;
OC Alligator.
OX NCBI_TaxID=38654 {ECO:0000313|Proteomes:UP000189705, ECO:0000313|RefSeq:XP_025048606.1};
RN [1] {ECO:0000313|RefSeq:XP_025048606.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 3 family. GABA-B
CC receptor subfamily. {ECO:0000256|ARBA:ARBA00008991}.
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DR RefSeq; XP_014381679.1; XM_014526193.1.
DR RefSeq; XP_014381680.1; XM_014526194.1.
DR RefSeq; XP_025048606.1; XM_025192821.1.
DR AlphaFoldDB; A0A1U8DVE6; -.
DR STRING; 38654.A0A1U8DVE6; -.
DR KEGG; asn:102367911; -.
DR eggNOG; KOG1055; Eukaryota.
DR InParanoid; A0A1U8DVE6; -.
DR OrthoDB; 5396723at2759; -.
DR Proteomes; UP000189705; Unplaced.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0004965; F:G protein-coupled GABA receptor activity; IEA:InterPro.
DR GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR GO; GO:0009058; P:biosynthetic process; IEA:InterPro.
DR CDD; cd15292; 7tmC_GPR156; 1.
DR InterPro; IPR002455; GPCR3_GABA-B.
DR InterPro; IPR017978; GPCR_3_C.
DR InterPro; IPR041946; GPR156_7TM.
DR InterPro; IPR002057; Isopenicillin-N_synth_CS.
DR PANTHER; PTHR10519:SF63; G-PROTEIN COUPLED RECEPTOR 156-RELATED; 1.
DR PANTHER; PTHR10519; GABA-B RECEPTOR; 1.
DR Pfam; PF00003; 7tm_3; 1.
DR PRINTS; PR01176; GABABRECEPTR.
DR PROSITE; PS50259; G_PROTEIN_RECEP_F3_4; 1.
DR PROSITE; PS00186; IPNS_2; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170,
KW ECO:0000313|RefSeq:XP_025048606.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000189705};
KW Transducer {ECO:0000256|ARBA:ARBA00023224};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 52..79
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 91..111
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 131..150
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 170..192
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 230..253
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 265..288
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 294..316
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 65..319
FT /note="G-protein coupled receptors family 3 profile"
FT /evidence="ECO:0000259|PROSITE:PS50259"
FT REGION 421..487
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 527..548
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 667..711
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 363..397
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 427..441
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 447..461
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 674..694
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 814 AA; 89685 MW; BE591518A6B0FF5C CRC64;
MEPGLNCSDL CDSDSTVSSQ VWRPSSLPEL CTVTITTSAG SGKISPFPSS SAALLGIVWM
FLTSGVLLAL FFLAFTIRFR NNRIVKMSSP NLNIVTLLGS SFTYVSAYLF GMQEQDLFPG
TSMEVLVQVR LCLLCVGTSL VLGPVLGKTW RLYRVFTQRV PDKRVIIKDL QLLVMVAVLV
LADGILLLTW VFSDPVQCFR SLSASMRATE KGVTCSVSRM QFCASLYSDL WLVLILGFKG
ILLICGTYLA GLTDNVSSPP VNQSLTLIVS VNLVLLTTGT VLLANRFFYT WPNLVFGFTS
GGIFVCTTTI NCFVFVPQLR HWKSFEEEES QTINHMAKYF NSPSKSFLSM YSEEQIYQLI
GEKNSMRRLL TEKNAVIESL QEQVNNAKEK LMKLMSADCG YDPMHPALPS TSLSLSLQNT
NHHVKPSGCD MDAEEPLEDH IPPGQEAGSW QCSSPPHPQC SPVSLSKEDC AGDTQDHNSY
TSHHCTPPED PACSLIQPCD SVGISEYNSN RLQEKWVPQS SKKIPGSLLG PLSQSPAAAG
EGAAQAENSA MMKEQPLRFN YVSSEKLQEI LQELSLGSMV GAQASPWGSR QARHSAQQER
RFVWRSQEKN LSPYMTWRRR RIPLHSPPPS YPGSTSPLVW CVVNQTVGRA AAGQGCDEVA
CVPQAKAGDH SDGRCLGQTS SSSPADNGQD QPEQHNHVSS KHPGLDQAKN CSTVQHPLHT
PLQEEDALRE LRRPLMPSLY CYPDSDSSSS SEEVFHCCHR PYCEICFQDP CVSSDSSVTD
TDPEPGEPLT LRTKLYGRSQ PVVNFKEDLT PTFV
//
