ID A0A1U8GK21_CAPAN Unreviewed; 994 AA.
AC A0A1U8GK21;
DT 10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT 10-MAY-2017, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE SubName: Full=Disease resistance protein RGA2 {ECO:0000313|EMBL:PHT93100.1};
GN ORFNames=T459_00982 {ECO:0000313|EMBL:PHT93100.1};
OS Capsicum annuum (Capsicum pepper).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC asterids; lamiids; Solanales; Solanaceae; Solanoideae; Capsiceae; Capsicum.
OX NCBI_TaxID=4072 {ECO:0000313|EMBL:PHT93100.1, ECO:0000313|Proteomes:UP000222542};
RN [1] {ECO:0000313|EMBL:PHT93100.1, ECO:0000313|Proteomes:UP000222542}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. CM334 {ECO:0000313|Proteomes:UP000222542};
RX PubMed=29089032; DOI=10.1186/s13059-017-1341-9;
RA Kim S., Park J., Yeom S.I., Kim Y.M., Seo E., Kim K.T., Kim M.S., Lee J.M.,
RA Cheong K., Shin H.S., Kim S.B., Han K., Lee J., Park M., Lee H.A.,
RA Lee H.Y., Lee Y., Oh S., Lee J.H., Choi E., Choi E., Lee S.E., Jeon J.,
RA Kim H., Choi G., Song H., Lee J., Lee S.C., Kwon J.K., Lee H.Y., Koo N.,
RA Hong Y., Kim R.W., Kang W.H., Huh J.H., Kang B.C., Yang T.J., Lee Y.H.,
RA Bennetzen J.L., Choi D.;
RT "New reference genome sequences of hot pepper reveal the massive evolution
RT of plant disease-resistance genes by retroduplication.";
RL Genome Biol. 18:R210.1-R210.11(2017).
CC -!- SIMILARITY: Belongs to the disease resistance NB-LRR family.
CC {ECO:0000256|ARBA:ARBA00008894}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PHT93100.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AYRZ02000001; PHT93100.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1U8GK21; -.
DR STRING; 4072.A0A1U8GK21; -.
DR EnsemblPlants; PHT93100; PHT93100; T459_00982.
DR Gramene; PHT93100; PHT93100; T459_00982.
DR OMA; FHLDERI; -.
DR Proteomes; UP000222542; Chromosome 1.
DR GO; GO:0043531; F:ADP binding; IEA:InterPro.
DR GO; GO:0050832; P:defense response to fungus; IEA:InterPro.
DR CDD; cd14798; RX-CC_like; 1.
DR Gene3D; 1.20.5.4130; -; 1.
DR Gene3D; 1.10.8.430; Helical domain of apoptotic protease-activating factors; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 2.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR042197; Apaf_helical.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR002182; NB-ARC.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR039203; RGA2/3-like.
DR InterPro; IPR038005; RX-like_CC.
DR InterPro; IPR041118; Rx_N.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR PANTHER; PTHR36766:SF33; DISEASE RESISTANCE RPP13-LIKE PROTEIN 1-RELATED; 1.
DR PANTHER; PTHR36766; PLANT BROAD-SPECTRUM MILDEW RESISTANCE PROTEIN RPW8; 1.
DR Pfam; PF00931; NB-ARC; 1.
DR Pfam; PF18052; Rx_N; 1.
DR PRINTS; PR00364; DISEASERSIST.
DR SMART; SM00369; LRR_TYP; 3.
DR SUPFAM; SSF52058; L domain-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51450; LRR; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Plant defense {ECO:0000256|ARBA:ARBA00022821};
KW Reference proteome {ECO:0000313|Proteomes:UP000222542};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 5..87
FT /note="Disease resistance N-terminal"
FT /evidence="ECO:0000259|Pfam:PF18052"
FT DOMAIN 162..396
FT /note="NB-ARC"
FT /evidence="ECO:0000259|Pfam:PF00931"
SQ SEQUENCE 994 AA; 113440 MW; 15870BFB5802C68D CRC64;
MAEAFLQVLL NKLTFFIQGE LGLVLGFEKE FKNLSSMFSM IQAVLEDAQE KQLKYRAIKN
WLQKLNVAAY EVDDILDECK TEAARFKQAV LGRLHPLTIT FRYKVGKRMK ELMEKLDAIA
EERRNFHLDE RIVERQASRR ETGFVLTELE VYGRDKEEDE IVKILINNVS DAQELLVLPI
LGIGGLGKTT LAQMVFNNQR VTEHFNLKIW VCVSDDFDEK RLIKAIVESV EGKSLGDMDL
APMQKKLQEL LNGKRYFLVL DDVWNEDQEK WASLKAVLRV GASGSSILIT TRLEKIGSIM
GTLQLYQLSN LSQEDCWLLF KQRAFGHQME TNPNLTAIGK EIVKKCGGVP LAAKTLGGLL
RFKREESEWE HMRDSEIWNL PQDENSVLPA LRLSYHHLPL DLRQCFAYCA VFPKDTKIEK
EYLVTLWMAH GFILSKGNME LEDVGNEVWK ELYLRSFFQE IEVKSSKTYF KMHDLIHDLA
TSMFSASASS SNIRQINVKD DEDMMFIVQD YKDMMSIGFV DVVSSYSPSL FKRFVSLRVL
NLSNLEFEKL SSSIGDLVHL RYLDLSGNKI CSLPKRLCKL QNLQTLDLYN CQSLSCLPKQ
TSNLVSLRNL VLDHCPLTSM PPRIGLLTCL KRISYFLVGE KKGYQLGELR NLNLRGTVSI
THLERVKDNT EAKEANLSAK ANLHFLSMSW DGPHGYESEE VKVLEALKPH PNLKYLEIIG
FSGFRFPDWM NHLVLKNVVS ILINSCKNCS CLSPFGELPC LESLELQDGS AEVEYVEDDD
VHSGFPLKRF PSLRKLHIGG FCNLKGLQRT EREEQFPMLE EMKISDCPML VFPTLSSVKK
LEIWGEADAR GLSSISNLRT LTSLKIFSNH KATSLLEEMF KSLANLKYLS ISYFENLKEL
PTSLTSLNDL KCLDIRYCYA LESLPEEGLE GLTSLMELFV EHCNMLKSLP EALQHLTALT
NLRVTGCPEV AKRCERGTGE DWHKIAHIPN VYIG
//
