ID A0A1U8HRH0_GOSHI Unreviewed; 416 AA.
AC A0A1U8HRH0;
DT 10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT 10-MAY-2017, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=Lipase {ECO:0000256|PIRNR:PIRNR000862};
GN Name=LOC107888853 {ECO:0000313|RefSeq:XP_016668591.1};
OS Gossypium hirsutum (Upland cotton) (Gossypium mexicanum).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Malvales; Malvaceae; Malvoideae; Gossypium.
OX NCBI_TaxID=3635 {ECO:0000313|Proteomes:UP000189702, ECO:0000313|RefSeq:XP_016668591.1};
RN [1] {ECO:0000313|Proteomes:UP000189702}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. TM-1 {ECO:0000313|Proteomes:UP000189702};
RX PubMed=25893780; DOI=10.1038/nbt.3208;
RA Li F., Fan G., Lu C., Xiao G., Zou C., Kohel R.J., Ma Z., Shang H., Ma X.,
RA Wu J., Liang X., Huang G., Percy R.G., Liu K., Yang W., Chen W., Du X.,
RA Shi C., Yuan Y., Ye W., Liu X., Zhang X., Liu W., Wei H., Wei S., Huang G.,
RA Zhang X., Zhu S., Zhang H., Sun F., Wang X., Liang J., Wang J., He Q.,
RA Huang L., Wang J., Cui J., Song G., Wang K., Xu X., Yu J.Z., Zhu Y., Yu S.;
RT "Genome sequence of cultivated Upland cotton (Gossypium hirsutum TM-1)
RT provides insights into genome evolution.";
RL Nat. Biotechnol. 33:524-530(2015).
RN [2] {ECO:0000313|RefSeq:XP_016668591.1}
RP IDENTIFICATION.
RC TISSUE=Leaf {ECO:0000313|RefSeq:XP_016668591.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the AB hydrolase superfamily. Lipase family.
CC {ECO:0000256|ARBA:ARBA00010701, ECO:0000256|PIRNR:PIRNR000862}.
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DR RefSeq; XP_016668591.1; XM_016813102.1.
DR AlphaFoldDB; A0A1U8HRH0; -.
DR STRING; 3635.A0A1U8HRH0; -.
DR PaxDb; 3635-A0A1U8HRH0; -.
DR GeneID; 107888853; -.
DR KEGG; ghi:107888853; -.
DR OrthoDB; 1214460at2759; -.
DR Proteomes; UP000189702; Chromosome 13.
DR GO; GO:0016788; F:hydrolase activity, acting on ester bonds; IEA:InterPro.
DR GO; GO:0016042; P:lipid catabolic process; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR006693; AB_hydrolase_lipase.
DR InterPro; IPR025483; Lipase_euk.
DR PANTHER; PTHR11005; LYSOSOMAL ACID LIPASE-RELATED; 1.
DR PANTHER; PTHR11005:SF99; TRIACYLGLYCEROL LIPASE 2; 1.
DR Pfam; PF04083; Abhydro_lipase; 1.
DR PIRSF; PIRSF000862; Steryl_ester_lip; 1.
DR SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|PIRNR:PIRNR000862};
KW Lipid degradation {ECO:0000256|PIRNR:PIRNR000862};
KW Lipid metabolism {ECO:0000256|PIRNR:PIRNR000862};
KW Reference proteome {ECO:0000313|Proteomes:UP000189702};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..29
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 30..416
FT /note="Lipase"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5010557368"
FT DOMAIN 55..113
FT /note="Partial AB-hydrolase lipase"
FT /evidence="ECO:0000259|Pfam:PF04083"
FT ACT_SITE 188
FT /note="Nucleophile"
FT /evidence="ECO:0000256|PIRSR:PIRSR000862-1"
FT ACT_SITE 358
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PIRSR:PIRSR000862-1"
FT ACT_SITE 391
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PIRSR:PIRSR000862-1"
SQ SEQUENCE 416 AA; 46075 MW; 33C563EAE6EB2D8F CRC64;
MQVMAFSPTG LLSLVVFMVL VVEPHPAYSS SRGGWFGRNQ GAATPLVNGI CAASVTIHGY
KCEEHQVKTQ DGYILNMQRI PEGRIGGNSS GNKKQPVLIQ HGVLVDGMTW LLNSPQQNLP
MILAENGFDV WLANTRGTRF CRHHVSLQPS QSEFWDWSWD ELVSYDLPAV FDFVFNHTAQ
KIHYIGHSLG TLIGLASFSE GHQEDQLKSA AFLSPVAYLT HMKTALGAVA ARAFVGEITT
LFGVAEFNPK GQQASIFLKA LCNYPGVDCY DLVTAITGKN CCLNASTVDL FLQNEPQSTA
TKNMVHLAQT VRDGVIAKYN YGRPDYNLMH YGEARPPIYN ISNIPKDLPI FISYGGQDAL
SDVEDVGQLL DNLKYHDVNK LSIQYIKDYA HADFIMGVNA KDIVYNQVVS FFKNQQ
//
