ID A0A1U8I105_GOSHI Unreviewed; 950 AA.
AC A0A1U8I105;
DT 10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT 10-MAY-2017, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE RecName: Full=Vacuolar protein sorting-associated protein 41 homolog {ECO:0000256|PIRNR:PIRNR028921};
GN Name=LOC107891587 {ECO:0000313|RefSeq:XP_016671922.1};
OS Gossypium hirsutum (Upland cotton) (Gossypium mexicanum).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Malvales; Malvaceae; Malvoideae; Gossypium.
OX NCBI_TaxID=3635 {ECO:0000313|Proteomes:UP000189702, ECO:0000313|RefSeq:XP_016671922.1};
RN [1] {ECO:0000313|Proteomes:UP000189702}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. TM-1 {ECO:0000313|Proteomes:UP000189702};
RX PubMed=25893780; DOI=10.1038/nbt.3208;
RA Li F., Fan G., Lu C., Xiao G., Zou C., Kohel R.J., Ma Z., Shang H., Ma X.,
RA Wu J., Liang X., Huang G., Percy R.G., Liu K., Yang W., Chen W., Du X.,
RA Shi C., Yuan Y., Ye W., Liu X., Zhang X., Liu W., Wei H., Wei S., Huang G.,
RA Zhang X., Zhu S., Zhang H., Sun F., Wang X., Liang J., Wang J., He Q.,
RA Huang L., Wang J., Cui J., Song G., Wang K., Xu X., Yu J.Z., Zhu Y., Yu S.;
RT "Genome sequence of cultivated Upland cotton (Gossypium hirsutum TM-1)
RT provides insights into genome evolution.";
RL Nat. Biotechnol. 33:524-530(2015).
RN [2] {ECO:0000313|RefSeq:XP_016671922.1}
RP IDENTIFICATION.
RC TISSUE=Leaf {ECO:0000313|RefSeq:XP_016671922.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Required for vacuolar assembly and vacuolar traffic.
CC {ECO:0000256|PIRNR:PIRNR028921}.
CC -!- SIMILARITY: Belongs to the VPS41 family.
CC {ECO:0000256|ARBA:ARBA00009582, ECO:0000256|PIRNR:PIRNR028921}.
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DR RefSeq; XP_016671922.1; XM_016816433.1.
DR AlphaFoldDB; A0A1U8I105; -.
DR STRING; 3635.A0A1U8I105; -.
DR PaxDb; 3635-A0A1U8I105; -.
DR GeneID; 107891587; -.
DR KEGG; ghi:107891587; -.
DR OrthoDB; 8838at2759; -.
DR Proteomes; UP000189702; Chromosome 14.
DR GO; GO:0030897; C:HOPS complex; IBA:GO_Central.
DR GO; GO:0005770; C:late endosome; IBA:GO_Central.
DR GO; GO:0009267; P:cellular response to starvation; IBA:GO_Central.
DR GO; GO:0034058; P:endosomal vesicle fusion; IBA:GO_Central.
DR GO; GO:0006886; P:intracellular protein transport; IEA:UniProtKB-UniRule.
DR GO; GO:0016236; P:macroautophagy; IBA:GO_Central.
DR GO; GO:0006623; P:protein targeting to vacuole; IBA:GO_Central.
DR GO; GO:0007034; P:vacuolar transport; IEA:UniProtKB-UniRule.
DR CDD; cd16687; RING-H2_Vps8; 1.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR000547; Clathrin_H-chain/VPS_repeat.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR016902; VPS41.
DR InterPro; IPR045111; Vps41/Vps8.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR12616; VACUOLAR PROTEIN SORTING VPS41; 1.
DR PANTHER; PTHR12616:SF1; VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 41 HOMOLOG; 1.
DR Pfam; PF00637; Clathrin; 1.
DR Pfam; PF00400; WD40; 1.
DR PIRSF; PIRSF028921; VPS41; 1.
DR SMART; SM00299; CLH; 1.
DR SMART; SM00320; WD40; 2.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS50236; CHCR; 1.
PE 3: Inferred from homology;
KW Protein transport {ECO:0000256|PIRNR:PIRNR028921};
KW Reference proteome {ECO:0000313|Proteomes:UP000189702};
KW Transport {ECO:0000256|PIRNR:PIRNR028921}.
FT REGION 1..46
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 840..859
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 924..950
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 11..38
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 844..858
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 950 AA; 106973 MW; 0AFD488330992262 CRC64;
MSPFPSENGV EGDDEREEEE DEDVDDDEEE EEAEEDEEEP RLKYQRMGGS IPSLLSGEAA
SCISVAERMI ALGTHDGTVH ILDFLGNQVK EFAAHSAAVN DLSFDIEGEY IGSCSDDGSV
VLNSLFTDEK LKFEYHRPMK AIALDPDYAR KTSRRFVTGG LAGHLYFNTK KWLGYKDQVL
HSGEGPIHAV KWRTSLIAWA NDAGVKVYDA ANDQRITFIE RPRGTPHPEI LLPHLVWQDD
TLLVIGWGTS VKIAAIRANL NKGTNGTYKR VTSNMNQVDI VASFQTSYYI SGIAPFADAL
VVLAYIPSED GEKEFSSAMP SRQQGNAQRP EVRIVSWNND ELATDALPVH GFEHYKAKDY
SLAHAPFSGS SYAGGQWAAG DEPIYYIVSP KDVVIAKPRD AEDHISWLLQ HGWHEKALAA
VEAGQGRSEL LDEVGSRYLD HLIVERKYAE AASLCPKLLR GSATAWERWV FHFAHLRQLP
VLVPYMPTEN PRLRDTAYEV ALVALATNPS FHKDLLSTVK SWPRVIYSAL PVISAIEPQL
NTSSMTDALK EALAELYVIN GQYEKAFSLY ADLMKPDIFD FIEKHNLHDS IREKVVQLMM
VDCKQAVNLL IQNRDLIAPS EVVSQLLNTR NKCDSRYFLH LYLHSLFEVN PHAGKDFHDM
QVELYVEYEP KMLLPFLRSS QHYTLEKAYE ICDRRDLLRE QVFILGRMGN SKQALAVIIN
ELGDIEEAVE FVTMQHDDDL WEELIHQCLH KPEMVGVLLE HTVGNLDPLY IVNMVPNGLE
IPRLRDRLVK IITDYRTETS LRHGCNDILK ADCVNLSVKY YNEAKRAVCL SNEEDDARSK
RDASRASQII TPSVRNMEVK SKTRGGGRCC MCFDPFSIQN VSVVVFFCCH AYHTTCLMES
TEINSTNKKG TGGPSEGLYE YEYEEEQEDD NGSEAGGPRM RCSLCTTATS
//
