ID A0A1U8ICR7_GOSHI Unreviewed; 1192 AA.
AC A0A1U8ICR7;
DT 10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT 10-MAY-2017, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Kinesin-like protein KIN12B isoform X3 {ECO:0000313|RefSeq:XP_016675991.1};
GN Name=LOC107895225 {ECO:0000313|RefSeq:XP_016675991.1};
OS Gossypium hirsutum (Upland cotton) (Gossypium mexicanum).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Malvales; Malvaceae; Malvoideae; Gossypium.
OX NCBI_TaxID=3635 {ECO:0000313|Proteomes:UP000189702, ECO:0000313|RefSeq:XP_016675991.1};
RN [1] {ECO:0000313|Proteomes:UP000189702}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. TM-1 {ECO:0000313|Proteomes:UP000189702};
RX PubMed=25893780; DOI=10.1038/nbt.3208;
RA Li F., Fan G., Lu C., Xiao G., Zou C., Kohel R.J., Ma Z., Shang H., Ma X.,
RA Wu J., Liang X., Huang G., Percy R.G., Liu K., Yang W., Chen W., Du X.,
RA Shi C., Yuan Y., Ye W., Liu X., Zhang X., Liu W., Wei H., Wei S., Huang G.,
RA Zhang X., Zhu S., Zhang H., Sun F., Wang X., Liang J., Wang J., He Q.,
RA Huang L., Wang J., Cui J., Song G., Wang K., Xu X., Yu J.Z., Zhu Y., Yu S.;
RT "Genome sequence of cultivated Upland cotton (Gossypium hirsutum TM-1)
RT provides insights into genome evolution.";
RL Nat. Biotechnol. 33:524-530(2015).
RN [2] {ECO:0000313|RefSeq:XP_016675991.1}
RP IDENTIFICATION.
RC TISSUE=Leaf {ECO:0000313|RefSeq:XP_016675991.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC superfamily. Kinesin family. KIN-12 subfamily.
CC {ECO:0000256|ARBA:ARBA00034488}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_016675991.1; XM_016820502.1.
DR AlphaFoldDB; A0A1U8ICR7; -.
DR GeneID; 107895225; -.
DR OrthoDB; 467304at2759; -.
DR Proteomes; UP000189702; Chromosome 15.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0008017; F:microtubule binding; IEA:InterPro.
DR GO; GO:0003777; F:microtubule motor activity; IEA:InterPro.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR Gene3D; 3.40.850.10; Kinesin motor domain; 1.
DR InterPro; IPR044986; KIF15/KIN-12.
DR InterPro; IPR001752; Kinesin_motor_dom.
DR InterPro; IPR036961; Kinesin_motor_dom_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR37739:SF16; KINESIN-LIKE PROTEIN; 1.
DR PANTHER; PTHR37739; KINESIN-LIKE PROTEIN KIN-12D; 1.
DR Pfam; PF00225; Kinesin; 1.
DR PRINTS; PR00380; KINESINHEAVY.
DR SMART; SM00129; KISc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS50067; KINESIN_MOTOR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|PROSITE-ProRule:PRU00283};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175, ECO:0000256|PROSITE-
KW ProRule:PRU00283};
KW Nucleotide-binding {ECO:0000256|PROSITE-ProRule:PRU00283};
KW Reference proteome {ECO:0000313|Proteomes:UP000189702}.
FT DOMAIN 115..453
FT /note="Kinesin motor"
FT /evidence="ECO:0000259|PROSITE:PS50067"
FT REGION 30..110
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 600..619
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 750..773
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 460..487
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1049..1139
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 40..95
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 752..773
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 190..197
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00283"
SQ SEQUENCE 1192 AA; 133677 MW; A3E57E5C280BE683 CRC64;
MKSTAEAAVA ENGRFLGSIS TSSLRNLLPK SKLKKSIKKS NSENTPPPDP NIIQINNSAQ
FSPKSPLSKS LTSDSFVNPS DAHPQISLSM DSSVKQKDMV ESEEQNGDLT NLDPSVKVVV
RIRPINGQEK EVDRTVTKVS SDSLSVGGRK FTFDSVLDAN SSQENVFQLI GVPLVKNALA
GYNTSVLSYG QTGSGKTYTM WGPPSAMVED PSPASHQGIV PRIFQMLFSE IQREQENSDG
RQTNYQCRCS FLEIYNEQIG DLLDPTQRNL EIKDDPKNGL YVENLTEEYV SSYEDVTQVL
IKGLSSRKVG ATTVNSKSSR SHIVFTFFIE SWCKQGASSK CFSSSKTSRI SLIDLAGLDR
NKLEDVGRQH LQEGKNVKKS LSQLGYLVNT LAKETQPEKP EDVPYGGSCL TRILRESLGG
NAKLTVMCNI SADNRNTSEI LSTLRFGQRV KAVRNEPVIN EISEDDVNGL SDQIRQLKEE
LIRAKSDAYS SVGSKSGYFK GWNARESLNQ LRISLNRSLI LPRIDNEYEE EINIGEDDVK
ELRQQLDYLD SSCETNLRDP LDKRGSIQSS VKESCETDLL SEYDIHCPKE TEIEEIDEVE
VPPMSSPEPA DDLSVTSKTL KAVDPSIRNS ISISPHRRSS ILEEPTLSES PKIANNLRKS
MAVPSALLAS QKNVSESSES EVLRELLKYS DHIRSSLRTS KTFLGPTESL AASLQRGRQI
IDQHQHSSVP NRSSVAFSFE HLMLKPSPEA DKANASVQTL PNDKPSPDGS STPLFCSSCQ
RKFDNNHPDE VQDSLKTWIV TVDNQQRDGR NTVEEASKKE KTLESVCKEQ AAKIEPLTQL
VKKYKLEREN SAIEHAPEPL KNEIILFDEQ SNNGENGKEY FDMTEKEALL QEIQTLKSKL
QSYTASPSPN KSTEILRSSL LSRSIQLRKS VDCRNNSEEE LERERQRWME MESDWISLTD
ELRMDLESNR CRAEKVEMEL KLEKKCTEEL DDALSRAVLG HARMVEHYAD LQEKYNDLVS
KHRAIMEGIA EIKKAAAKAG SKGHGARFAK SLAAELSAIR VEREREKEQL KKENRSLRTQ
LRDTAEAVHA AGELLVRLRE AEQAASIAEE NFSNVQQENE KLKKQADKLK RKHKMEMVTM
KQYLAESRLP ESALQPLYRE DSDVAASHNS SAIPYDDQAW RAEFGAIYQE HY
//
