ID   A0A1U8J5U4_GOSHI        Unreviewed;       937 AA.
AC   A0A1U8J5U4;
DT   10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT   10-MAY-2017, sequence version 1.
DT   27-MAR-2024, entry version 22.
DE   SubName: Full=DNA topoisomerase 2-binding protein 1-A-like isoform X2 {ECO:0000313|RefSeq:XP_016685710.1};
GN   Name=LOC107903981 {ECO:0000313|RefSeq:XP_016685710.1};
OS   Gossypium hirsutum (Upland cotton) (Gossypium mexicanum).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Malvales; Malvaceae; Malvoideae; Gossypium.
OX   NCBI_TaxID=3635 {ECO:0000313|Proteomes:UP000189702, ECO:0000313|RefSeq:XP_016685710.1};
RN   [1] {ECO:0000313|Proteomes:UP000189702}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. TM-1 {ECO:0000313|Proteomes:UP000189702};
RX   PubMed=25893780; DOI=10.1038/nbt.3208;
RA   Li F., Fan G., Lu C., Xiao G., Zou C., Kohel R.J., Ma Z., Shang H., Ma X.,
RA   Wu J., Liang X., Huang G., Percy R.G., Liu K., Yang W., Chen W., Du X.,
RA   Shi C., Yuan Y., Ye W., Liu X., Zhang X., Liu W., Wei H., Wei S., Huang G.,
RA   Zhang X., Zhu S., Zhang H., Sun F., Wang X., Liang J., Wang J., He Q.,
RA   Huang L., Wang J., Cui J., Song G., Wang K., Xu X., Yu J.Z., Zhu Y., Yu S.;
RT   "Genome sequence of cultivated Upland cotton (Gossypium hirsutum TM-1)
RT   provides insights into genome evolution.";
RL   Nat. Biotechnol. 33:524-530(2015).
RN   [2] {ECO:0000313|RefSeq:XP_016685710.1}
RP   IDENTIFICATION.
RC   TISSUE=Leaf {ECO:0000313|RefSeq:XP_016685710.1};
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR   RefSeq; XP_016685710.1; XM_016830221.1.
DR   AlphaFoldDB; A0A1U8J5U4; -.
DR   OrthoDB; 449768at2759; -.
DR   Proteomes; UP000189702; Chromosome 19.
DR   GO; GO:0005694; C:chromosome; IEA:UniProt.
DR   GO; GO:0005634; C:nucleus; IEA:UniProt.
DR   CDD; cd00027; BRCT; 1.
DR   CDD; cd17731; BRCT_TopBP1_rpt2_like; 2.
DR   CDD; cd17718; BRCT_TopBP1_rpt3; 1.
DR   Gene3D; 3.40.50.10190; BRCT domain; 6.
DR   InterPro; IPR001357; BRCT_dom.
DR   InterPro; IPR036420; BRCT_dom_sf.
DR   PANTHER; PTHR13561; DNA REPLICATION REGULATOR DPB11-RELATED; 1.
DR   PANTHER; PTHR13561:SF20; DNA TOPOISOMERASE 2-BINDING PROTEIN 1; 1.
DR   Pfam; PF00533; BRCT; 2.
DR   Pfam; PF16589; BRCT_2; 1.
DR   Pfam; PF12738; PTCB-BRCT; 2.
DR   SMART; SM00292; BRCT; 5.
DR   SUPFAM; SSF52113; BRCT domain; 5.
DR   PROSITE; PS50172; BRCT; 5.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000189702}.
FT   DOMAIN          103..187
FT                   /note="BRCT"
FT                   /evidence="ECO:0000259|PROSITE:PS50172"
FT   DOMAIN          185..274
FT                   /note="BRCT"
FT                   /evidence="ECO:0000259|PROSITE:PS50172"
FT   DOMAIN          377..469
FT                   /note="BRCT"
FT                   /evidence="ECO:0000259|PROSITE:PS50172"
FT   DOMAIN          568..656
FT                   /note="BRCT"
FT                   /evidence="ECO:0000259|PROSITE:PS50172"
FT   DOMAIN          669..752
FT                   /note="BRCT"
FT                   /evidence="ECO:0000259|PROSITE:PS50172"
FT   REGION          494..518
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          805..830
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        494..511
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        808..830
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   937 AA;  103619 MW;  22F7EE0EFA688725 CRC64;
     MMMTTKAKAF MGSNVFMSRN LVPPEVFDKL HGVLKDNGAQ VFLCSDPSRN GPDDFHVISS
     FDHEKFEDLR TKGCNLIGPQ CVISCANENR ALPQQGFSCC LAMDGLKVLA SGFDMDEKVK
     IEKLVIAMGG VLHTKASLDV SFVIVKNVLA AKYKWALNVL KKPIVTIQWL YQCWSEHRVV
     PQESYRVLPF TGLTISVTGI RADERKEIEK LIIQNGGKYS AELTKKCTHL ICDVPEGDKY
     KVARRWGHVH IIVRKWFDQC IARRACLNEE SYPVQGGSAS SKKSVSGSLS AQHSQDKFRA
     SSVSATSLVV PEFNMSTVPS TGLGDPDLEA AHSQNTPSVL SDAQAIFEED GGEAPNLKPS
     TETKLDGCVA NDSQSEDNDL YLSDCKISLV GFEASEMRKL VTMVRRGGAS RYMSCNEKLT
     HIVVGAPSEL EKKEVRSIAA SGVIHVVKTS WLEDCDRQKK EIPVHQRHVA YDLLLPKDSA
     HSVRGAVTGI INSNQSKSSV PTNSGTGMPS SFGKSLDDKP KINMNGGSCL KATVGSSKQG
     LLPTINSTSN FWQKQQSDSV VQNPKNGISS AVFKGKTFCF SVSFPEDRRA EIVEWVDQGG
     GQVVEDQVKK NVNFIIECHG VIPSCIADSQ ITYVSTHWVR SCLEDGCLLD VGSHILYSPL
     PCQIPFPGFK NFRFCVSQYE EKDRLLLRNL CFILGAKFVE KLTKKVTHLL CKFTSGPKYE
     AACKWGIRSV TSEWIYECLR QNKVVSLDPF CPKEVTAQDQ EAGLCTVSQF PTQAAKMIAV
     DVPSQFTSQP QGLRTQDLGV KMGSITGDRN DGSRDEAEQS NDHFKRARHL EDDDQNDLLA
     SRVHLCEPFL NENSTGNNKL KNAGEAAQVL PDVDTVIDLL EQTSKIHDQK SPERNGCDRS
     VFLSDCTGLR QDHTDSHSVI GLSRHWLNRK LNQERTY
//