ID A0A1U8J9G6_GOSHI Unreviewed; 853 AA.
AC A0A1U8J9G6;
DT 10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT 10-MAY-2017, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=Uncharacterized protein LOC107904944 {ECO:0000313|RefSeq:XP_016686977.1};
GN Name=LOC107904944 {ECO:0000313|RefSeq:XP_016686977.1};
OS Gossypium hirsutum (Upland cotton) (Gossypium mexicanum).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Malvales; Malvaceae; Malvoideae; Gossypium.
OX NCBI_TaxID=3635 {ECO:0000313|Proteomes:UP000189702, ECO:0000313|RefSeq:XP_016686977.1};
RN [1] {ECO:0000313|Proteomes:UP000189702}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. TM-1 {ECO:0000313|Proteomes:UP000189702};
RX PubMed=25893780; DOI=10.1038/nbt.3208;
RA Li F., Fan G., Lu C., Xiao G., Zou C., Kohel R.J., Ma Z., Shang H., Ma X.,
RA Wu J., Liang X., Huang G., Percy R.G., Liu K., Yang W., Chen W., Du X.,
RA Shi C., Yuan Y., Ye W., Liu X., Zhang X., Liu W., Wei H., Wei S., Huang G.,
RA Zhang X., Zhu S., Zhang H., Sun F., Wang X., Liang J., Wang J., He Q.,
RA Huang L., Wang J., Cui J., Song G., Wang K., Xu X., Yu J.Z., Zhu Y., Yu S.;
RT "Genome sequence of cultivated Upland cotton (Gossypium hirsutum TM-1)
RT provides insights into genome evolution.";
RL Nat. Biotechnol. 33:524-530(2015).
RN [2] {ECO:0000313|RefSeq:XP_016686977.1}
RP IDENTIFICATION.
RC TISSUE=Leaf {ECO:0000313|RefSeq:XP_016686977.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|PIRSR:PIRSR601577-2};
CC Note=Binds 1 zinc ion per subunit. {ECO:0000256|PIRSR:PIRSR601577-2};
CC -!- SIMILARITY: Belongs to the peptidase M8 family.
CC {ECO:0000256|ARBA:ARBA00005860}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR RefSeq; XP_016686977.1; XM_016831488.1.
DR AlphaFoldDB; A0A1U8J9G6; -.
DR STRING; 3635.A0A1U8J9G6; -.
DR PaxDb; 3635-A0A1U8J9G6; -.
DR GeneID; 107904944; -.
DR KEGG; ghi:107904944; -.
DR OrthoDB; 24037at2759; -.
DR Proteomes; UP000189702; Chromosome 19.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.
DR GO; GO:0008233; F:peptidase activity; IBA:GO_Central.
DR GO; GO:0007155; P:cell adhesion; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR Gene3D; 3.10.170.20; -; 1.
DR Gene3D; 2.10.25.10; Laminin; 2.
DR Gene3D; 3.90.132.10; Leishmanolysin , domain 2; 1.
DR Gene3D; 2.10.55.10; Leishmanolysin domain 3; 1.
DR Gene3D; 2.30.34.10; Leishmanolysin domain 4; 1.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR036790; Frizzled_dom_sf.
DR InterPro; IPR001577; Peptidase_M8.
DR PANTHER; PTHR10942; LEISHMANOLYSIN-LIKE PEPTIDASE; 1.
DR PANTHER; PTHR10942:SF0; LEISHMANOLYSIN-LIKE PEPTIDASE; 1.
DR Pfam; PF01457; Peptidase_M8; 1.
DR PRINTS; PR00782; LSHMANOLYSIN.
DR SUPFAM; SSF63501; Frizzled cysteine-rich domain; 1.
DR SUPFAM; SSF55486; Metalloproteases ('zincins'), catalytic domain; 1.
DR PROSITE; PS00022; EGF_1; 1.
DR PROSITE; PS01186; EGF_2; 1.
DR PROSITE; PS50026; EGF_3; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|PROSITE-ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|PROSITE-ProRule:PRU00076};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|PIRSR:PIRSR601577-2};
KW Metalloprotease {ECO:0000256|ARBA:ARBA00023049,
KW ECO:0000256|PIRSR:PIRSR601577-2}; Protease {ECO:0000256|ARBA:ARBA00022670};
KW Reference proteome {ECO:0000313|Proteomes:UP000189702};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|PIRSR:PIRSR601577-2}.
FT TRANSMEM 7..27
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 627..659
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT ACT_SITE 291
FT /evidence="ECO:0000256|PIRSR:PIRSR601577-1"
FT BINDING 290
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_note="catalytic"
FT /evidence="ECO:0000256|PIRSR:PIRSR601577-2"
FT BINDING 294
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_note="catalytic"
FT /evidence="ECO:0000256|PIRSR:PIRSR601577-2"
FT BINDING 370
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_note="catalytic"
FT /evidence="ECO:0000256|PIRSR:PIRSR601577-2"
FT DISULFID 631..641
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 649..658
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 853 AA; 94441 MW; 0EC65D5633726605 CRC64;
MVTRFDFKLR FAVVIFEVLL ILLWFGAATS KFQGHHPQWE GPERGIGENI VSHSCIHDQI
IEQRRRPGRK VYSVTPQFYV HSSTSNNVLH KGRSLLEISE VLEHPKEAKQ PIRIYLNYDA
VGLSPDRDCR KVGDIVKLGE PPVSSSLGTR SCNPHGDPPI YGDCWYNCTL NDLSGQDKRH
RLHKALGQTA DWFKRTLAVE SVKGNLRLSG YSACGQDGGV QLPRQYVEEG VADADLVLLV
TTRPTTGNTL AWAVACERDQ WGRAIAGHVN VAPRHLTAEA ETLLSATLIH EVMHVLGFDP
HAFTHFRDER KRRHSKVTEH IIDERLGRMV KRVVLPRVVM HSRHHYGAFS ENFTGLELED
GGGRGTSGSH WEKRLLMNEI MTGSVDTKSV VSKMTLALLE DSGWYQANYS MADHLDWGYN
QGTDFLTSPC NLWKGAYHCN TTNLSGCTYN REAEGYCPIV SYNRDLPQWT RYFPQANKGG
QSSLADYCTF FVAYSDGSCT DSNSARAPDR MLGEVRGSNS RCMASSLVRT GFVRGSMTQG
NGCYQHRCVN YSLEVAVDGI WKVCAKAGGP VQFPGFNGEL ICPAYHELCS AGPVPVSGQC
PNSCNFNGDC VSGKCRCFPG FHRHDCSKRY CPSNCNGHGM CLSNGVCGCE NGYTGIDCST
AVCDEQCSLH GGVCDNGVCE FRCSDYAGYT CQNSSTLLSS LSVCKNELER ELSGQHCAPS
EASILQQLEE VVIMPNYYRL FPSVAQKLFT NLFGSSYCES AAKRLACWIS IQKCDNDGDN
RLRVCHSACQ AYNLACGASL DCSDQTLFSS GEEGEGQCTG SGEMKVSWFN RFRNRLFSSN
SSLKGVYVKY SQL
//
