ID A0A1U8JA02_GOSHI Unreviewed; 1076 AA.
AC A0A1U8JA02;
DT 10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT 10-MAY-2017, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=NHL repeat-containing protein 2-like isoform X2 {ECO:0000313|RefSeq:XP_016685488.1};
GN Name=LOC107903827 {ECO:0000313|RefSeq:XP_016685488.1};
OS Gossypium hirsutum (Upland cotton) (Gossypium mexicanum).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Malvales; Malvaceae; Malvoideae; Gossypium.
OX NCBI_TaxID=3635 {ECO:0000313|Proteomes:UP000189702, ECO:0000313|RefSeq:XP_016685488.1};
RN [1] {ECO:0000313|Proteomes:UP000189702}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. TM-1 {ECO:0000313|Proteomes:UP000189702};
RX PubMed=25893780; DOI=10.1038/nbt.3208;
RA Li F., Fan G., Lu C., Xiao G., Zou C., Kohel R.J., Ma Z., Shang H., Ma X.,
RA Wu J., Liang X., Huang G., Percy R.G., Liu K., Yang W., Chen W., Du X.,
RA Shi C., Yuan Y., Ye W., Liu X., Zhang X., Liu W., Wei H., Wei S., Huang G.,
RA Zhang X., Zhu S., Zhang H., Sun F., Wang X., Liang J., Wang J., He Q.,
RA Huang L., Wang J., Cui J., Song G., Wang K., Xu X., Yu J.Z., Zhu Y., Yu S.;
RT "Genome sequence of cultivated Upland cotton (Gossypium hirsutum TM-1)
RT provides insights into genome evolution.";
RL Nat. Biotechnol. 33:524-530(2015).
RN [2] {ECO:0000313|RefSeq:XP_016685488.1}
RP IDENTIFICATION.
RC TISSUE=Leaf {ECO:0000313|RefSeq:XP_016685488.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_016685488.1; XM_016829999.1.
DR AlphaFoldDB; A0A1U8JA02; -.
DR OMA; INCIHAL; -.
DR OrthoDB; 5475197at2759; -.
DR Proteomes; UP000189702; Chromosome 19.
DR CDD; cd07505; HAD_BPGM-like; 1.
DR CDD; cd14951; NHL-2_like; 1.
DR Gene3D; 3.40.30.10; Glutaredoxin; 1.
DR Gene3D; 3.40.50.1000; HAD superfamily/HAD-like; 1.
DR Gene3D; 2.120.10.30; TolB, C-terminal domain; 2.
DR InterPro; IPR011042; 6-blade_b-propeller_TolB-like.
DR InterPro; IPR036412; HAD-like_sf.
DR InterPro; IPR006439; HAD-SF_hydro_IA.
DR InterPro; IPR041492; HAD_2.
DR InterPro; IPR023214; HAD_sf.
DR InterPro; IPR045302; NHL2_NHL_rpt_dom.
DR InterPro; IPR001258; NHL_repeat.
DR InterPro; IPR023198; PGP-like_dom2.
DR InterPro; IPR012336; Thioredoxin-like_fold.
DR InterPro; IPR036249; Thioredoxin-like_sf.
DR InterPro; IPR013766; Thioredoxin_domain.
DR NCBIfam; TIGR01509; HAD-SF-IA-v3; 1.
DR PANTHER; PTHR46388; NHL REPEAT-CONTAINING PROTEIN 2; 1.
DR PANTHER; PTHR46388:SF2; NHL REPEAT-CONTAINING PROTEIN 2; 1.
DR Pfam; PF13419; HAD_2; 1.
DR Pfam; PF01436; NHL; 1.
DR Pfam; PF13905; Thioredoxin_8; 1.
DR PRINTS; PR00413; HADHALOGNASE.
DR SFLD; SFLDG01135; C1.5.6:_HAD__Beta-PGM__Phospha; 1.
DR SFLD; SFLDG01129; C1.5:_HAD__Beta-PGM__Phosphata; 1.
DR SUPFAM; SSF56784; HAD-like; 1.
DR SUPFAM; SSF101898; NHL repeat; 1.
DR SUPFAM; SSF52833; Thioredoxin-like; 1.
DR PROSITE; PS51125; NHL; 1.
DR PROSITE; PS51352; THIOREDOXIN_2; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000189702};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 412..558
FT /note="Thioredoxin"
FT /evidence="ECO:0000259|PROSITE:PS51352"
FT REPEAT 824..854
FT /note="NHL"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00504"
SQ SEQUENCE 1076 AA; 117741 MW; A6E103943A62F7B2 CRC64;
MAVRLLSTPT ALSDPTKLSF FSSPKPISTA TSFFQWRSKC RIFTRKMVVK ACVKVEEKNV
KETSKQEWGK VTAVLFDMDG VLCNSENPSR KAAVDVFAEM GVQVIAEDFA PFTGMGEANF
LGGVASVKGV KEFNTEAAKK RFFEIYLDKY AKPNSGIGFP GAFELINECK NKGLKVAVAS
SADRVKVDAN LAAAGLPLSM FDAIVSADAF ENLKPAPDIF LAASKILDVS PDECLVIEDA
LAGVQAANAA KMRCIAVTTT LTEETLKPAG PSIIRNDIGS VSLDDILSGG SDEMVQNMRF
LQVTEQNPSR ILNERTRNGS TPGVDVPSNE VFSLQGLQGS RRDILRYGSL GIALSCLYFA
VSNWKAMQYA SPKAIWNMLF AAKNPFFGPT EDESHSARIQ QFVNYISDLE SRGTAPKVPE
FPAKLDWLNT APLQFQRDLQ GKVVLLDFWT YCCINCMHVL PDLDFLEKKY KAKPFTVIGV
HSAKFDNEKD LEAIRNAVLR YGITHPVVND GDMYLWQELG VNSWPTFAIV GPNGKLLAQI
AGEGHRKDLD YLVEAALIFY DQKKLLDNKP IPLNLEKDND PRMLTSPLKF PGKLAIDILN
NRLFVSDSNH NRIVVTDLDG NFIVQIGSTG EEGLHDGSFD DATFNRPQGL AYNAKKNLLY
VADTENHALR EIDFVNEKVQ TLAGNETKGS DYTGGGKGAS QLLNSPWDVC FDPVNEKVYV
AMAGQHQIWE HSIQDGVTKA FSGNGCERNL NGSSSTNTSF AQPSGISLSP DLMEAYVADS
ESSSIRALDL KTGGSRLLAG GDPVFSENLF RFGDHDGIGS DVLLQHPLGV LCAKDGQIYI
ADSYNHKIKK LDPASKRVTT LAGTGKAGFK DGKALAAQLS EPSGIIEAEN GRLIIADTNN
SLIRYLDLNK ENAEILTLEL KGVQPPTPKS KSLRRIRKRS SADTQTIVVN GGSSSEGNLY
LKISLPEEYH FSKEAQSKFT VDIEPANAVS IDPLDGKLSP EGSTKLHFRR STSSAFTGMI
NCKVYYCKED EVCLYQSLLF EVPFQEEDPQ AKPADIKLVY DVKPKASTNS LQLIAP
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