ID A0A1U8JDJ6_GOSHI Unreviewed; 658 AA.
AC A0A1U8JDJ6;
DT 10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT 10-MAY-2017, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Cation/calcium exchanger 4-like {ECO:0000313|RefSeq:XP_016688386.1};
GN Name=LOC107906051 {ECO:0000313|RefSeq:XP_016688386.1};
OS Gossypium hirsutum (Upland cotton) (Gossypium mexicanum).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Malvales; Malvaceae; Malvoideae; Gossypium.
OX NCBI_TaxID=3635 {ECO:0000313|Proteomes:UP000189702, ECO:0000313|RefSeq:XP_016688386.1};
RN [1] {ECO:0000313|Proteomes:UP000189702}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. TM-1 {ECO:0000313|Proteomes:UP000189702};
RX PubMed=25893780; DOI=10.1038/nbt.3208;
RA Li F., Fan G., Lu C., Xiao G., Zou C., Kohel R.J., Ma Z., Shang H., Ma X.,
RA Wu J., Liang X., Huang G., Percy R.G., Liu K., Yang W., Chen W., Du X.,
RA Shi C., Yuan Y., Ye W., Liu X., Zhang X., Liu W., Wei H., Wei S., Huang G.,
RA Zhang X., Zhu S., Zhang H., Sun F., Wang X., Liang J., Wang J., He Q.,
RA Huang L., Wang J., Cui J., Song G., Wang K., Xu X., Yu J.Z., Zhu Y., Yu S.;
RT "Genome sequence of cultivated Upland cotton (Gossypium hirsutum TM-1)
RT provides insights into genome evolution.";
RL Nat. Biotechnol. 33:524-530(2015).
RN [2] {ECO:0000313|RefSeq:XP_016688386.1}
RP IDENTIFICATION.
RC TISSUE=Leaf {ECO:0000313|RefSeq:XP_016688386.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19)
CC family. Cation/calcium exchanger (CCX) subfamily.
CC {ECO:0000256|ARBA:ARBA00038187}.
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DR RefSeq; XP_016688386.1; XM_016832897.1.
DR AlphaFoldDB; A0A1U8JDJ6; -.
DR STRING; 3635.A0A1U8JDJ6; -.
DR PaxDb; 3635-A0A1U8JDJ6; -.
DR GeneID; 107906051; -.
DR KEGG; ghi:107906051; -.
DR OrthoDB; 3087817at2759; -.
DR Proteomes; UP000189702; Chromosome 19.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0008324; F:monoatomic cation transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0006812; P:monoatomic cation transport; IBA:GO_Central.
DR Gene3D; 1.20.1420.30; NCX, central ion-binding region; 2.
DR InterPro; IPR004837; NaCa_Exmemb.
DR InterPro; IPR044880; NCX_ion-bd_dom_sf.
DR PANTHER; PTHR12266:SF0; MITOCHONDRIAL SODIUM_CALCIUM EXCHANGER PROTEIN; 1.
DR PANTHER; PTHR12266; NA+/CA2+ K+ INDEPENDENT EXCHANGER; 1.
DR Pfam; PF01699; Na_Ca_ex; 2.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000189702};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 16..34
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 145..163
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 222..241
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 253..273
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 279..301
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 458..476
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 488..506
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 512..536
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 557..586
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 592..616
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 628..652
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 152..293
FT /note="Sodium/calcium exchanger membrane region"
FT /evidence="ECO:0000259|Pfam:PF01699"
FT DOMAIN 493..644
FT /note="Sodium/calcium exchanger membrane region"
FT /evidence="ECO:0000259|Pfam:PF01699"
SQ SEQUENCE 658 AA; 71699 MW; 84DE239089BF90A6 CRC64;
MRNHCLYASK NPKFRGIFNG LSALILIFLF YTRVDFLRNP HIRQSSRLIN HVTQGPGFTD
GYDHFSVIRR KISELDANSS TLADKNAQEN DLNVSSSNPA LCYGLLDHMG FANPCEFLKA
HPQCSSDGFF DYIKFFYCGC GEFRIAGYVV LGVWLAALFY LLGNTAADYF CCSLEKLSHL
LRLPPTVAGV SLLPLGNGAP DVFASIAAFL GTDTGEVGLN SVLGGAVFVT CVVVGTVSLC
VAEKRIQIDT RCFIRDICFF LFTLISLMMM LVIGKVSVAG AIAFVMIYVI YAFSVAANEL
LRKHARGLKL DVVTPLLPVH GSPFLQGSEE ETFAYSSLLE MDTENEPPQL PSSLPQWMWA
SNVAIYSNNF MKINSADEER PPWGWTEKGM ETNGSSFSCS KLISLLELPL TVPRRLTIPL
VEQESWSKPY AVASASLAPV LMAFLWNSQG DVGSHTRVVA WCIGVAVGCI LGILARKHTL
SDHPPQRFLI PWVLGGFFMS IVWFYIIANE LVALLVTFGV IFGINPSILG VTILAWGNSM
GDLVSNVALA MNGDDGVQIA FSGCYAGPMF NTLVGLGISM LLGAWSKSPS PYLIPVDSSL
FFTIGFLMSG LIWALIVLPR SDMRPSKILG AGLIMLYVIF LSLRLSSAVG FVSVGGLS
//
