ID A0A1U8JH90_GOSHI Unreviewed; 1776 AA.
AC A0A1U8JH90;
DT 10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT 10-MAY-2017, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=1,3-beta-glucan synthase {ECO:0000256|ARBA:ARBA00012589};
DE EC=2.4.1.34 {ECO:0000256|ARBA:ARBA00012589};
DE AltName: Full=1,3-beta-glucan synthase {ECO:0000256|ARBA:ARBA00032165};
GN Name=LOC107905780 {ECO:0000313|RefSeq:XP_016688023.1};
OS Gossypium hirsutum (Upland cotton) (Gossypium mexicanum).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Malvales; Malvaceae; Malvoideae; Gossypium.
OX NCBI_TaxID=3635 {ECO:0000313|Proteomes:UP000189702, ECO:0000313|RefSeq:XP_016688023.1};
RN [1] {ECO:0000313|Proteomes:UP000189702}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. TM-1 {ECO:0000313|Proteomes:UP000189702};
RX PubMed=25893780; DOI=10.1038/nbt.3208;
RA Li F., Fan G., Lu C., Xiao G., Zou C., Kohel R.J., Ma Z., Shang H., Ma X.,
RA Wu J., Liang X., Huang G., Percy R.G., Liu K., Yang W., Chen W., Du X.,
RA Shi C., Yuan Y., Ye W., Liu X., Zhang X., Liu W., Wei H., Wei S., Huang G.,
RA Zhang X., Zhu S., Zhang H., Sun F., Wang X., Liang J., Wang J., He Q.,
RA Huang L., Wang J., Cui J., Song G., Wang K., Xu X., Yu J.Z., Zhu Y., Yu S.;
RT "Genome sequence of cultivated Upland cotton (Gossypium hirsutum TM-1)
RT provides insights into genome evolution.";
RL Nat. Biotechnol. 33:524-530(2015).
RN [2] {ECO:0000313|RefSeq:XP_016688023.1}
RP IDENTIFICATION.
RC TISSUE=Leaf {ECO:0000313|RefSeq:XP_016688023.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=[(1->3)-beta-D-glucosyl](n) + UDP-alpha-D-glucose = [(1->3)-
CC beta-D-glucosyl](n+1) + H(+) + UDP; Xref=Rhea:RHEA:21476, Rhea:RHEA-
CC COMP:11146, Rhea:RHEA-COMP:14303, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:37671, ChEBI:CHEBI:58223, ChEBI:CHEBI:58885; EC=2.4.1.34;
CC Evidence={ECO:0000256|ARBA:ARBA00000192};
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the glycosyltransferase 48 family.
CC {ECO:0000256|ARBA:ARBA00009040}.
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DR RefSeq; XP_016688023.1; XM_016832534.1.
DR STRING; 3635.A0A1U8JH90; -.
DR PaxDb; 3635-A0A1U8JH90; -.
DR OrthoDB; 354539at2759; -.
DR Proteomes; UP000189702; Chromosome 19.
DR GO; GO:0000148; C:1,3-beta-D-glucan synthase complex; IEA:InterPro.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0003843; F:1,3-beta-D-glucan synthase activity; IEA:UniProtKB-EC.
DR GO; GO:0046527; F:glucosyltransferase activity; IBA:GO_Central.
DR GO; GO:0006075; P:(1->3)-beta-D-glucan biosynthetic process; IEA:InterPro.
DR GO; GO:0071555; P:cell wall organization; IEA:UniProtKB-KW.
DR GO; GO:0008360; P:regulation of cell shape; IEA:UniProtKB-KW.
DR InterPro; IPR026899; FKS1-like_dom1.
DR InterPro; IPR003440; Glyco_trans_48.
DR PANTHER; PTHR12741:SF102; CALLOSE SYNTHASE 11; 1.
DR PANTHER; PTHR12741; LYST-INTERACTING PROTEIN LIP5 DOPAMINE RESPONSIVE PROTEIN DRG-1; 1.
DR Pfam; PF14288; FKS1_dom1; 1.
DR Pfam; PF02364; Glucan_synthase; 1.
DR SMART; SM01205; FKS1_dom1; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Cell shape {ECO:0000256|ARBA:ARBA00022960};
KW Cell wall biogenesis/degradation {ECO:0000256|ARBA:ARBA00023316};
KW Glycosyltransferase {ECO:0000256|ARBA:ARBA00022676};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000189702};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 315..334
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 383..405
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 426..452
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 489..509
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 541..565
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1342..1367
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1512..1536
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1587..1608
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1620..1641
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1653..1674
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1681..1704
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1724..1743
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 163..279
FT /note="1,3-beta-glucan synthase component FKS1-like"
FT /evidence="ECO:0000259|SMART:SM01205"
FT REGION 1..25
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1776 AA; 206344 MW; 681878614229A882 CRC64;
MTSLRQRPVP TRGRGANPRS QPPPPMQQVY NIIPVHDLIA DHPSLRYPEV RAVASALLRP
VLNLPKPPFV TLAPNMDLMD WLGVSFGFQN DNVRNQRENL VLHLANCQMR LQPPPANPDE
VDRGVLQSFR KKLLHNYTSW CSFLRVKPHV HLPSRRGNSY DPTRELLYVS LYLLIWGEAA
NLRFCPELLS YIYHHMAMEL TKFLDQHIDE FTGRPFVPSI SGDCAFLKSI VMPFYRTIKT
EVENSRNGTA PHSAWRNYDD INEYFWSRRC FKTLKWPINY GCNFFDTAPK TERVGKTGFV
EQRSFWNVFR SFDRLWILLI LFLQASIIVA WTGKKFPWDA LKERDVQVDL LTVFITWAGL
RFWQSVLDAG TQYSLVSKER VWLGIRMVLK SMAALTWIVV FAVFYQRIWS QKNADRGWYP
EADQRIVTFL EAVFVYLIPE MLSILFFVIP WVRNWIEGLD WMVVSWLTWW FHTRTFVGRG
LREGLVDNIR YTLFWIVVFL WKFSFSYFLQ IKPLVGPTKV LLNLPNVRYN WHQFFGNSNR
FAVMLLWTPV VLIYFVDLQI WYLVFSSFVG ATNGLFSHLG EIRNMEQLRL RFQFFASAMQ
FNLMPEDQLL SPKATLVKKF RDAIHRLKLR YGLGQPYKKI ESSQVEATRF ALIWNEIIIT
LREEDLISDR EVELMELPPN CWNIRVIRWP CFLLCNEFLL ALSQAKELAD APDLWLWVKI
CKNEYGRCAV IEAYDSIKHV LLTLIRYGTE EYNIVLTLFE KIDFCVQNGQ LTASYKMAVL
QKIHGKLVSL IDLLVKQKND LSQTVNLLQA LYELCVREFP KKQRPIYELM EEGLAPKNVA
ADGLLFENAI NIPDAEDADF YKQLRRLQTI LTSKDSMHNV PLNLEARRRI AFFSNSLFMN
MPHAPNVEKM MAFSVLTPYY DEDVLYKKGM LQDENEDGIS TLFYLQKIYE DEWRNFIERM
HREGMDDDED DIWREKLRDL RLWASYRGQT LSRTVRGMMY YYRALKMLSF LDSASEMDIR
MGTQEIATHH SLNNRNRDAI KLPTAKKFNR AVSGVSLLFK GHEYGFALMK FTYVVTCQLY
GRQKAKGESH AEEILFLMKN NEALRVAYVD EVELGRNEVE YYSVLVKYDQ QLQREVEIYR
IRLPGPLKLG EGKPENQNHA IIFTRGDAIQ TIDMNQDNYF EEALKMRNLL EEFKTNYGIR
KPTILGVREN VFTGSVSSLA RFMSAQETSF VTLGQRVLAN PLKVRMHYGH PDVFDRFWFL
TRGGISKASR VINISEDIFA GFNCTLRGGN VTHHEYIQVG KGRDVGLNQI SMFEAKVASG
NGEQILSRDV YRLGHRLDFF RMFSFFFSTV GHYFNTMVVV LTVYTFLWGR LYLALSGVEG
GAKNQSISSE AVGTILNQQF VIQLGLFTAL PMVVENSLEH GFLPAIWDFL KMQLQLASFF
FTFSMGTRTH FFGRTILHGG AKYRATGRGF VVEHKRFAEN YRLYARSHFV KAIELGVILA
VYASYSPLAK DSFVYIALTI SSWFLVVSWI MSPFVFNPSG FDWLKTVYDF DDFINWIWSS
GGAASEANKS WEIWWYEEQH HLRTTGLWGK LLEIILDLRF FFFQYGIVYQ LGIAGKRTSV
AVYLVSWTFM IVAVGIYVVI AYAQDKYAAK KHIYYRVVQL VVIVLTVLVI VLLLEFTPFK
FTDLVTSLMA FIPTGWGLIL IAQVLRPFLQ STVVWDTVVS LARLYDLLFG LIVIAPVALV
SWLPGFQAMQ TRILFNEAFS RGLQISRIIS GKKSTA
//
