ID A0A1U8JMK4_GOSHI Unreviewed; 1549 AA.
AC A0A1U8JMK4;
DT 10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT 10-MAY-2017, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE RecName: Full=non-specific serine/threonine protein kinase {ECO:0000256|ARBA:ARBA00012513};
DE EC=2.7.11.1 {ECO:0000256|ARBA:ARBA00012513};
GN Name=LOC107907182 {ECO:0000313|RefSeq:XP_016689928.1};
OS Gossypium hirsutum (Upland cotton) (Gossypium mexicanum).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Malvales; Malvaceae; Malvoideae; Gossypium.
OX NCBI_TaxID=3635 {ECO:0000313|Proteomes:UP000189702, ECO:0000313|RefSeq:XP_016689928.1};
RN [1] {ECO:0000313|Proteomes:UP000189702}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. TM-1 {ECO:0000313|Proteomes:UP000189702};
RX PubMed=25893780; DOI=10.1038/nbt.3208;
RA Li F., Fan G., Lu C., Xiao G., Zou C., Kohel R.J., Ma Z., Shang H., Ma X.,
RA Wu J., Liang X., Huang G., Percy R.G., Liu K., Yang W., Chen W., Du X.,
RA Shi C., Yuan Y., Ye W., Liu X., Zhang X., Liu W., Wei H., Wei S., Huang G.,
RA Zhang X., Zhu S., Zhang H., Sun F., Wang X., Liang J., Wang J., He Q.,
RA Huang L., Wang J., Cui J., Song G., Wang K., Xu X., Yu J.Z., Zhu Y., Yu S.;
RT "Genome sequence of cultivated Upland cotton (Gossypium hirsutum TM-1)
RT provides insights into genome evolution.";
RL Nat. Biotechnol. 33:524-530(2015).
RN [2] {ECO:0000313|RefSeq:XP_016689928.1}
RP IDENTIFICATION.
RC TISSUE=Leaf {ECO:0000313|RefSeq:XP_016689928.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_016689928.1; XM_016834439.1.
DR STRING; 3635.A0A1U8JMK4; -.
DR PaxDb; 3635-A0A1U8JMK4; -.
DR GeneID; 107907182; -.
DR KEGG; ghi:107907182; -.
DR OrthoDB; 5477296at2759; -.
DR Proteomes; UP000189702; Chromosome 19.
DR GO; GO:0005770; C:late endosome; IBA:GO_Central.
DR GO; GO:0071561; C:nucleus-vacuole junction; IBA:GO_Central.
DR GO; GO:0034271; C:phosphatidylinositol 3-kinase complex, class III, type I; IBA:GO_Central.
DR GO; GO:0034272; C:phosphatidylinositol 3-kinase complex, class III, type II; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IBA:GO_Central.
DR GO; GO:0045324; P:late endosome to vacuole transport; IBA:GO_Central.
DR GO; GO:0016236; P:macroautophagy; IBA:GO_Central.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR GO; GO:0006623; P:protein targeting to vacuole; IBA:GO_Central.
DR CDD; cd13980; STKc_Vps15; 1.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 2.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 2.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR000357; HEAT.
DR InterPro; IPR021133; HEAT_type_2.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR008271; Ser/Thr_kinase_AS.
DR InterPro; IPR045162; Vps15-like.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR17583; PHOSPHOINOSITIDE 3-KINASE REGULATORY SUBUNIT 4; 1.
DR PANTHER; PTHR17583:SF0; PHOSPHOINOSITIDE 3-KINASE REGULATORY SUBUNIT 4; 1.
DR Pfam; PF02985; HEAT; 1.
DR Pfam; PF00069; Pkinase; 1.
DR Pfam; PF00400; WD40; 3.
DR SMART; SM00220; S_TKc; 1.
DR SMART; SM00320; WD40; 6.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS50077; HEAT_REPEAT; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 2.
DR PROSITE; PS50294; WD_REPEATS_REGION; 2.
PE 4: Predicted;
KW Kinase {ECO:0000256|ARBA:ARBA00022777};
KW Reference proteome {ECO:0000313|Proteomes:UP000189702};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Serine/threonine-protein kinase {ECO:0000256|ARBA:ARBA00022527};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}.
FT DOMAIN 27..307
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT REPEAT 547..579
FT /note="HEAT"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00103"
FT REPEAT 1130..1162
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 1520..1549
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REGION 1397..1433
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1408..1422
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1549 AA; 173788 MW; FE20AF50E53EDB32 CRC64;
MGNKIARTTQ VSATEYYLHD LPSSYNLVLK EVLGRGRFFK SILCKHDEGL VLVKVYFKRG
DSIDLREYER RLVHIKEIFR SLKHPHVWPF QFWQETDKAA YLLRQYFFNN LHDRLSSRPF
LSLVEKKWLA FQLLLAAKQC HEKGICHGDI KCENVLVTSW NWVYLADFAS FKPTYIPYDD
PSDFSFFFDT GGRRLCYLAP ERFYEHGGEM QVAQDAPLKP SMDIFAIGCV IAELFLEGQP
LFELSQLLAY RRGQYDPSQH LEKIPDIGVR KMILHMIQLE PESRLSAESY LQNYVAAVFP
SYFSPFLHGF YRCWNPLHSD MRIAMCQRVF PEMLKQMMSK RSSDEMGKGL GKSHTLSGHL
SQEIVAKQQS EEIAPKQKLS SANHLLTKRE KIDNASIRDQ FKLPGNINTL LGDVEQSNHY
LGEKSTRGDT PKYELSQDFK QHGMQSPVLH QNISDLFRKN DHPFLKKITM DDLNSLMSDY
DSQSDTFGMP FLPLPQDSMK CEGMVLVASL LCSCIRNVKL PHLRRGAILL LKTSSLYIDD
EDRLQRVLPY VIAMLSDPAA IVRCAALETL CDILPLVREF PPSDAKIFPE YILPMLSMLP
DDPEESVRIC YASNIAKLAL TAYGFLIHSI RLSEAGVLNE TNLPQKSLAS SGESSGRIQR
SNSDAQLGQL RKLIAEVVQE LVMGQKQTPN IRRALLQDVG NLCCFFGQRQ SNDFLLPILP
AFLNDRDEQL RAVFYGQIVF VCFFVGQRSV EEYLLPYIEQ ALGDAREAVI VNALDCLAVL
CNSGFLRKRI LIEMIERSFP LLCYPSQWVR RSVVTFLASS SECLGAVDSY VFLAPVIQPF
LRRQPASLDS EKALLSCLKP PVSREVFYEV LQNARSSDML ERQRKIWYNS SAQSKQWEIA
DLLERGTGEL DSMKYWSEKQ QSNGSHRPID SVLQQSGLTE AADDDAKLRA LGCNTRNASS
AIDMHDPLCL EKLQFSGLTS PQLNGLNSFM CDKSSEGIPL YSFSMDKRAT VAPSAASDTP
LPWMDPISKS FSLASSVPTP KLVSGSFGIT AGSKQFYRVV HEPESRENDQ IANANSKFQD
MGLSGTVKGS SVRMEDASTS TDFTGLPSFS RSSSIPDSGW RPRGVLVAHL QEHRSAVNDI
AVSNDHSFFV SASDDSTVKV WDSRKLEKDI SFRSRLTYHL EGSRALCTAM LRNSAQVVVG
ACDGTIHMFS VDHISKGLGN VVEKYSGIAD IKKKDVKEGA ILTLLNYPID NCGIQTFMYS
TQNCGIHLWD TRSSSNAWTL KAIPEEGYIS CLVAGPCGNW FVSGSSRGVL TLWDLRFRIP
VNSWQYSLVC PVEKMCLFVP PSSVSVSTTA RPLIYVAAGC NEVSLWNAEN GTCHQVFRAA
NYDSDAEMSD LPWALARPSA KTSSKSDPRR NANPRYRVDE LNEPPPRVPG IRSLLPLPGG
DLLTGGTDLR IRRWDHFSPD RSYCMCGPNF KGVGNDDFYE ARSSFGAQVV QETKRRPLTT
KLTAKAVLVA AATDSAGCHH DSVLSLASVK LNQRLLISSG RDGAIKVWK
//
