ID A0A1U8JSL5_GOSHI Unreviewed; 1275 AA.
AC A0A1U8JSL5;
DT 10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT 10-MAY-2017, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE RecName: Full=non-specific serine/threonine protein kinase {ECO:0000256|ARBA:ARBA00012513};
DE EC=2.7.11.1 {ECO:0000256|ARBA:ARBA00012513};
GN Name=LOC107910011 {ECO:0000313|RefSeq:XP_016693262.1};
OS Gossypium hirsutum (Upland cotton) (Gossypium mexicanum).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Malvales; Malvaceae; Malvoideae; Gossypium.
OX NCBI_TaxID=3635 {ECO:0000313|Proteomes:UP000189702, ECO:0000313|RefSeq:XP_016693262.1};
RN [1] {ECO:0000313|Proteomes:UP000189702}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. TM-1 {ECO:0000313|Proteomes:UP000189702};
RX PubMed=25893780; DOI=10.1038/nbt.3208;
RA Li F., Fan G., Lu C., Xiao G., Zou C., Kohel R.J., Ma Z., Shang H., Ma X.,
RA Wu J., Liang X., Huang G., Percy R.G., Liu K., Yang W., Chen W., Du X.,
RA Shi C., Yuan Y., Ye W., Liu X., Zhang X., Liu W., Wei H., Wei S., Huang G.,
RA Zhang X., Zhu S., Zhang H., Sun F., Wang X., Liang J., Wang J., He Q.,
RA Huang L., Wang J., Cui J., Song G., Wang K., Xu X., Yu J.Z., Zhu Y., Yu S.;
RT "Genome sequence of cultivated Upland cotton (Gossypium hirsutum TM-1)
RT provides insights into genome evolution.";
RL Nat. Biotechnol. 33:524-530(2015).
RN [2] {ECO:0000313|RefSeq:XP_016693262.1}
RP IDENTIFICATION.
RC TISSUE=Leaf {ECO:0000313|RefSeq:XP_016693262.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the protein kinase superfamily. Ser/Thr protein
CC kinase family. {ECO:0000256|ARBA:ARBA00008684}.
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DR RefSeq; XP_016693262.1; XM_016837773.1.
DR AlphaFoldDB; A0A1U8JSL5; -.
DR STRING; 3635.A0A1U8JSL5; -.
DR PaxDb; 3635-A0A1U8JSL5; -.
DR GeneID; 107910011; -.
DR KEGG; ghi:107910011; -.
DR OMA; RELCNAK; -.
DR OrthoDB; 366616at2759; -.
DR Proteomes; UP000189702; Chromosome 1.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 6.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR013210; LRR_N_plant-typ.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR InterPro; IPR008271; Ser/Thr_kinase_AS.
DR PANTHER; PTHR48056:SF58; LEUCINE-RICH REPEAT RECEPTOR PROTEIN KINASE MSP1-LIKE ISOFORM X1; 1.
DR PANTHER; PTHR48056; LRR RECEPTOR-LIKE SERINE/THREONINE-PROTEIN KINASE-RELATED; 1.
DR Pfam; PF00560; LRR_1; 15.
DR Pfam; PF13855; LRR_8; 2.
DR Pfam; PF08263; LRRNT_2; 1.
DR Pfam; PF07714; PK_Tyr_Ser-Thr; 1.
DR PRINTS; PR00019; LEURICHRPT.
DR SMART; SM00365; LRR_SD22; 7.
DR SMART; SM00369; LRR_TYP; 11.
DR SMART; SM00220; S_TKc; 1.
DR SUPFAM; SSF52058; L domain-like; 2.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR SUPFAM; SSF52047; RNI-like; 1.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU10141};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|RefSeq:XP_016693262.1};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU10141}; Receptor {ECO:0000313|RefSeq:XP_016693262.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000189702};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Serine/threonine-protein kinase {ECO:0000256|ARBA:ARBA00022527};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 22..1275
FT /note="non-specific serine/threonine protein kinase"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5010557441"
FT TRANSMEM 908..929
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 997..1275
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT BINDING 1026
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10141"
SQ SEQUENCE 1275 AA; 138801 MW; 4D56BFE454D35525 CRC64;
MEFKLLFHFL CFLHLLLSIS GATIEQADGN PDREALVSFK RGLQNPHFLS SWNQRIHFCK
WDGVTCRLGR VTSLSLPSRS LTGSLSPSLS SLSNLTLLDL SSNSFFGQIP TELAELTLLK
TLKLGSNSFT GNIPSELGSL NALRTLELST NALTGTVPAK LGQLTQLQFL DLANNFLSGS
FPSTLFENLQ SLTSLDISNN SFSGNIPPEI GELKNLTALY IGINQFTGKI PPEIGKLSLL
ENFFSPSCSI TGPLPKQLSN LKSLTKLDLS YNPLKCSIPK SIGKLQNLTI LNLVYTELNG
SIPAELGNCR NLMMLMLSFN SLSGSLPEEL SSLPMLTFSA ETNQLSGPLP PWLGKWTQVE
SLLLSNNHFS GNIPPEIENC SRLKHLSLSN NKLSGSIPRE LCNAKSLFEV DLDGNNLSVT
IEDVFVNCRN LAQLVLLNNH INGSIPEYLS ELPLMVIDLD SNNFTGTIPV SLWSSNSLME
FSAGNNMLEG TLPVDIGNAV TLETLVLSGN RLKGNIPKEI GNLTALSVLN LNSNFLEGNI
PVEIGYCKAL TTLDLGNNNF SGSIPMELAD LDQLQCLVLS HNNLSGSIPW KPSSYFHQAN
LPDLSFVQHH GVFDLSHNRL TGPIPEELGN CAVVVDLLLN NNMLTGWIPG SLSRLTNLTT
LDLSGNLLTG PIPVEFGDSL KLQGLYLGNN QLTGTISESL GRVGSLVKLN LTGNRLSGVV
PASFGNLKEL THLDLSNNKL AGELPSSLSQ MLNLVGLYVQ KNRLAGEIHN LFSNSVSWKI
EDLNLSNNIF YGSLPQSLGN LSYLMYLDLH GNKFSGAIPS EIGNLMQLEY FDLSRNRFSG
QIPAEVCGLF SLFYLNLAEN RLGGPVPRNG ICQNLSKIFL AGNNDLCGRI TGLECQIRCS
ERSSLLNAWG LAGIVAASVF IIFASAFAVR RWILRSGQLS DPEEIEESKL NNFLDQNLCF
LSSSSRSKEP LSINIATFEQ PLLKLTLGDI LEGTHHFCKT NIIGDGGFGT VYKAKLPSGK
TVAVKKLSQA KTQGNREFIA EMETLGKVKH QNLVPLLGYC SLGEEKLLVY EYMINGSLDL
WLRNRSGALD VLDWSKRFKI AVGAARGLAF LHHGFIPHII HRDIKASNIL LSEDFEAKVA
DFGLARLISA CETHVSTDIA GTFGYIPPEY GQSGRSTTKG DVFSFGVILL ELVTGKEPTG
PEFKEIEGGN LVGWVTKKIK KGQAADVLDP VVMGVDSKQM MLQVLSIAAV CLAENPANRP
TMLQVLKLLK GIHKE
//
