ID A0A1U8JY44_GOSHI Unreviewed; 2316 AA.
AC A0A1U8JY44;
DT 10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT 10-MAY-2017, sequence version 1.
DT 27-MAR-2024, entry version 34.
DE SubName: Full=Histone-lysine N-methyltransferase ASHH2-like {ECO:0000313|RefSeq:XP_016693673.1};
GN Name=LOC107910364 {ECO:0000313|RefSeq:XP_016693673.1};
OS Gossypium hirsutum (Upland cotton) (Gossypium mexicanum).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Malvales; Malvaceae; Malvoideae; Gossypium.
OX NCBI_TaxID=3635 {ECO:0000313|Proteomes:UP000189702, ECO:0000313|RefSeq:XP_016693673.1};
RN [1] {ECO:0000313|Proteomes:UP000189702}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. TM-1 {ECO:0000313|Proteomes:UP000189702};
RX PubMed=25893780; DOI=10.1038/nbt.3208;
RA Li F., Fan G., Lu C., Xiao G., Zou C., Kohel R.J., Ma Z., Shang H., Ma X.,
RA Wu J., Liang X., Huang G., Percy R.G., Liu K., Yang W., Chen W., Du X.,
RA Shi C., Yuan Y., Ye W., Liu X., Zhang X., Liu W., Wei H., Wei S., Huang G.,
RA Zhang X., Zhu S., Zhang H., Sun F., Wang X., Liang J., Wang J., He Q.,
RA Huang L., Wang J., Cui J., Song G., Wang K., Xu X., Yu J.Z., Zhu Y., Yu S.;
RT "Genome sequence of cultivated Upland cotton (Gossypium hirsutum TM-1)
RT provides insights into genome evolution.";
RL Nat. Biotechnol. 33:524-530(2015).
RN [2] {ECO:0000313|RefSeq:XP_016693673.1}
RP IDENTIFICATION.
RC TISSUE=Leaf {ECO:0000313|RefSeq:XP_016693673.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR RefSeq; XP_016693673.1; XM_016838184.1.
DR STRING; 3635.A0A1U8JY44; -.
DR PaxDb; 3635-A0A1U8JY44; -.
DR GeneID; 107910364; -.
DR KEGG; ghi:107910364; -.
DR OrthoDB; 54704at2759; -.
DR Proteomes; UP000189702; Chromosome 20.
DR GO; GO:0000785; C:chromatin; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0046975; F:histone H3K36 methyltransferase activity; IBA:GO_Central.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IBA:GO_Central.
DR CDD; cd19172; SET_SETD2; 1.
DR Gene3D; 3.30.40.100; -; 1.
DR Gene3D; 2.170.270.10; SET domain; 1.
DR InterPro; IPR006560; AWS_dom.
DR InterPro; IPR003616; Post-SET_dom.
DR InterPro; IPR001214; SET_dom.
DR InterPro; IPR046341; SET_dom_sf.
DR InterPro; IPR044437; SETD2/Set2_SET.
DR InterPro; IPR011124; Znf_CW.
DR PANTHER; PTHR22884:SF413; HISTONE-LYSINE N-METHYLTRANSFERASE CG1716-RELATED; 1.
DR PANTHER; PTHR22884; SET DOMAIN PROTEINS; 1.
DR Pfam; PF17907; AWS; 1.
DR Pfam; PF00856; SET; 1.
DR Pfam; PF07496; zf-CW; 1.
DR SMART; SM00570; AWS; 1.
DR SMART; SM00508; PostSET; 1.
DR SMART; SM00317; SET; 1.
DR SUPFAM; SSF82199; SET domain; 1.
DR PROSITE; PS51215; AWS; 1.
DR PROSITE; PS50868; POST_SET; 1.
DR PROSITE; PS50280; SET; 1.
DR PROSITE; PS51050; ZF_CW; 1.
PE 4: Predicted;
KW Chromosome {ECO:0000256|ARBA:ARBA00022454};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000189702};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT DOMAIN 1269..1322
FT /note="CW-type"
FT /evidence="ECO:0000259|PROSITE:PS51050"
FT DOMAIN 1383..1433
FT /note="AWS"
FT /evidence="ECO:0000259|PROSITE:PS51215"
FT DOMAIN 1427..1552
FT /note="SET"
FT /evidence="ECO:0000259|PROSITE:PS50280"
FT DOMAIN 1560..1576
FT /note="Post-SET"
FT /evidence="ECO:0000259|PROSITE:PS50868"
FT REGION 403..423
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 591..613
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 769..802
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 850..886
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 995..1015
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1054..1127
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1143..1247
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1631..1762
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2027..2046
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2092..2127
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2185..2287
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 996..1012
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1103..1125
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1154..1185
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1186..1223
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1230..1247
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1646..1670
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1685..1710
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1711..1732
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1733..1762
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2092..2121
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2203..2238
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2259..2280
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2316 AA; 251919 MW; 1FB995A0E283C065 CRC64;
MGSCGNMTFV NEPSREVASA AAEQHLCSES MGKLVSEQRA CVVIDSNGDY ASEPGEDENS
ACKRSGDIDC KVGIKGEAQI VGSGTKGLMG GECCENSVCL KKNGGEIADA SCSKALVGDM
CGDSVVCLEN NQGDLMGDSG LKELMGNAND DTVVCLKDEG EIMNDSDSKE LMDDRCRDCI
VYSIENQGEK EDGSFPLDLR SDTYRDSTVC SIGNQGENVD GAGSKELMVD MCGDAMVCLN
DNQGENPDCS GPEELMGYVD NTGYSNEIQC KNVDSGLNEL KGDRISDHGV GLNENQDDVD
IHDSVTDVCL EKSGPSGEDG TNAAKGSLGL SQDKNTAALS SGIEISTNCE DQMKGDNENV
VGLMLKECMG NNQGRICLTG NMDVDDHLDS ENDVSQDGEM PIELNTMSTS PRSSVKLDKQ
DDDERVNGSI LQRILEYGEM KFEEKNDAVE RKGTDVLNQI LLSENFKGPF ELIDATGEHK
SKDGMSTYCS SSEVAMEEKR EVLTEVEANI CNQMSSIQGS HLASTSIGIG DCRSDCPRQN
DLKDSNTIVG PSLDGESGAS PVIESDTCGK ISTSCCVETI SNLQQTGDSV GSCDGHNQKD
DLSSSGLSLE SFPKPVETKS TDDLCIELLA SRRLFDTQKN AQTVGNDISD SSGDGVAEVS
EGRTDFLAYT KAEISSEIII NAKGKACNSN RDSFEQGANC LCDKSTSLSC QPVDVVENGL
SGRLDPQDLL AKDACAAISS SSSIDCSGQG ENEGKDIVKA DCVLETKNYP TTSSSSRKGR
QKGKSSRKTP AKRGARNCSS TKLRHPHESM EFLFKATRRK RSCSSKPARS SIWGLFSNIA
KFIEPCPDPS CNEVQNRKPS KARGGRGSGK RSKNRAGQNR KESSGLSNTL TSCLRLKIKV
GKEVAPSNVN TLVAEVVDPS VLIGTSFSNY GKETNLQYPT VANIVEDKVE LGSEMRFQSK
EDQEMVKTCS DVFLTEVKLA NKAVRCSENL ERLSEDATDS SLISQSDAVA EASQEAIENK
CMDPGTSPDS EVINTIPDAQ IGLIHQEESL DTVLNTSGPL ASPRGAKTSK GSKRGKKDNH
RSPGTASTRK AKSSKSRRSR EKTTGNGLVS IEALTSSSAA NSSRENWIGV PKEATEMENS
MDIKDCCSPD VPDTKNTKHF SSSNSKCNQL SKSSRSQGAS KGKSRVSDSV KSRKAKGSKR
RGDESKSVSK SKVKEKCSDE EIVARGGKSP VTGNQISDDN EHLNTGNSIE SANMVNVDLV
PDGVMEQHTQ PDNAWVRCDD CHKWRRIPVS LVKSIDEAYH WVCGDNVDKA FADCSIPQEK
SNADINAELG ISDAEEDGCD GFNYKELEKG FETKRMTVSP PSHFWRIDSN QFLHRGRKTQ
TIDEIMVCQC KRPPDGKLGC GDECLNRMLN IECVQGTCPC GDLCSNQQFQ NRKYAMMKWD
RFGKKGFGLR MLENISAGHF LIEYVGEVLD MQAYEARQKE YASRGQRHFY FMTLNGSEVI
DAYVKGNLGR FINHSCDPNC RTEKWMVNGE ICIGLFALRD IKKGEEVTFD YNYVRVFGAA
AKKCHCGSPH CRGYIGGDPL SAEVIVHDDS DEESPEPMML EDGETWTGFK DVLSRSGSSD
GAAMQSVESV ITDGVLKPEN MPEAEDSVNR SASATSELNT VETEEASPVT IASESVKPDG
TEEQKAMNKT SCSIQKLDAS QDMSDNRLSS DVIDANKKSK SDAAEDKQVS AKSRPLMKTS
RSSSSIKKGK ISSNSLSGNK VQTTSNKFQV STVKPRKFSE NSSTCRFEAV EEKLNELLDS
VGGITKRKDA SKGYLKLLLL TATSGDSGGG EAIQSNRELS MILDALLKTK SGHVLTDIIN
KNGLQMLHNI MKKYRKDFKK IPILRKLLKV LEYLAGRGIL TQEHINGGPY CAGRESFRES
ILSFTEHDDK QVHQIARNFR DKWIRKPVRK LGYRDKDEGR MEFFRGLDCN RVSASHNHWR
DQAIRSTEAI NCIMQSVVGS TSSDTSTREG GSSLSVCLSQ TNSTRIRKRK SRWDQPADTE
KIDSQSPKKL ECSLLSALGQ ATPDQIEKMN SGDNKCQDSF SKGEAINIEN GNQSFQQDAP
PGFSSPLNAS LVSSTAPSTA TGFPPPKVGQ LKCPDVVIAH PQKRFISRLP VSYGIPLPIF
QQIRLPEGES LESWAIAPGI PFHPFPPLPP CPPDKKDTKP VSAALSTGIN ADSKEGQQES
RRPSTSCPDE SVASTAGGNH PDSDIPGTDI QQTLKRTRES SYDLGRKYFR QQKRKGPQWD
KSESLGNNHT GEICCIDVGN INNEPRNSYY SDDINQ
//
