ID A0A1U8K1I8_GOSHI Unreviewed; 734 AA.
AC A0A1U8K1I8;
DT 10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT 10-MAY-2017, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE RecName: Full=RING-type E3 ubiquitin transferase {ECO:0000256|ARBA:ARBA00012483};
DE EC=2.3.2.27 {ECO:0000256|ARBA:ARBA00012483};
GN Name=LOC107911522 {ECO:0000313|RefSeq:XP_016694843.1};
OS Gossypium hirsutum (Upland cotton) (Gossypium mexicanum).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Malvales; Malvaceae; Malvoideae; Gossypium.
OX NCBI_TaxID=3635 {ECO:0000313|Proteomes:UP000189702, ECO:0000313|RefSeq:XP_016694843.1};
RN [1] {ECO:0000313|Proteomes:UP000189702}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. TM-1 {ECO:0000313|Proteomes:UP000189702};
RX PubMed=25893780; DOI=10.1038/nbt.3208;
RA Li F., Fan G., Lu C., Xiao G., Zou C., Kohel R.J., Ma Z., Shang H., Ma X.,
RA Wu J., Liang X., Huang G., Percy R.G., Liu K., Yang W., Chen W., Du X.,
RA Shi C., Yuan Y., Ye W., Liu X., Zhang X., Liu W., Wei H., Wei S., Huang G.,
RA Zhang X., Zhu S., Zhang H., Sun F., Wang X., Liang J., Wang J., He Q.,
RA Huang L., Wang J., Cui J., Song G., Wang K., Xu X., Yu J.Z., Zhu Y., Yu S.;
RT "Genome sequence of cultivated Upland cotton (Gossypium hirsutum TM-1)
RT provides insights into genome evolution.";
RL Nat. Biotechnol. 33:524-530(2015).
RN [2] {ECO:0000313|RefSeq:XP_016694843.1}
RP IDENTIFICATION.
RC TISSUE=Leaf {ECO:0000313|RefSeq:XP_016694843.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Functions as an E3 ubiquitin ligase.
CC {ECO:0000256|ARBA:ARBA00003861}.
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC {ECO:0000256|ARBA:ARBA00004906}.
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DR RefSeq; XP_016694843.1; XM_016839354.1.
DR AlphaFoldDB; A0A1U8K1I8; -.
DR GeneID; 107911522; -.
DR OMA; IHAGSEQ; -.
DR OrthoDB; 37517at2759; -.
DR UniPathway; UPA00143; -.
DR Proteomes; UP000189702; Chromosome 21.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0004672; F:protein kinase activity; IEA:InterPro.
DR GO; GO:0004842; F:ubiquitin-protein transferase activity; IEA:InterPro.
DR GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR CDD; cd16655; RING-Ubox_WDSUB1-like; 1.
DR CDD; cd01989; STK_N; 1.
DR Gene3D; 3.40.50.620; HUPs; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR014729; Rossmann-like_a/b/a_fold.
DR InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR InterPro; IPR003613; Ubox_domain.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR45647; OS02G0152300 PROTEIN; 1.
DR PANTHER; PTHR45647:SF28; U-BOX DOMAIN-CONTAINING PROTEIN 33-LIKE; 1.
DR Pfam; PF07714; PK_Tyr_Ser-Thr; 1.
DR Pfam; PF04564; U-box; 1.
DR SMART; SM00504; Ubox; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS51698; U_BOX; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000189702};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786}.
FT DOMAIN 388..648
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT DOMAIN 667..734
FT /note="U-box"
FT /evidence="ECO:0000259|PROSITE:PS51698"
FT COILED 238..345
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 734 AA; 82634 MW; 022ADB145EE86059 CRC64;
MDRMTDAAET IYVAVGKAVE ESEHTLLWAL QNLCPTKVCI LHVHQPASLC NSSRMNFTAT
RLHQQDIGKK ILDRIMDDYL LICGQKSVEA AKLNIEMDDA GKGIVELIRD QGIKKLVMGA
AANKHFSEGM TDLKSEKAQY VELHAPPSCK IWFICGGQLV HRKSLVENGQ SNLSSSASSS
SYWTVSNKLA SSSDSSVSET LGESPDWLEF NEGSGDDKVF ENLEQALFIA EKSNQEAFDE
LDRRLKAEKD ALNAVVRQAN EMKSSYIGEL RRRKEIEGTL RKQNEELEQV KQQRDEARKI
ARTHKLLLES RGAKSDHVKV LEAKVSSAME QLQIYQRERD DLRAKLESTC MSIKDHSTIQ
EEGSSNVHMQ QFFSEFSVAE IHDATEDFDP SFKIAEGAYG SVYRCTLRHT EVAIKVLHQN
SLQGPLEFQK EVDILSKLRH PNLVTLIGVC PEIWALIYEY LPNGSLEDRL IPRDNTPPLS
WQTRIQIATE ICSALIFLHA SKPQRMVHGN LKPGNILLDT NFGCKLSDFG VCHVLSSLEK
SNNMTDISRK FPYLEPQFLN TRTLTPSSDI YSFGIILLQL ITGRPPLSII EDAQRAVNGN
RLNDLLDPSA GDWSYVEAEQ LTHLALRCCD TNRSRRPDLA SEVYKVLIRN TIGPLSTIHA
GSEQLRQPPD SFFCPISKKI MMDPHVAADG FTYELREIRR WLDGGHDTSP CTNIPLAHRI
LIPNHALRSA ILEW
//
