ID A0A1U8K3A7_GOSHI Unreviewed; 606 AA.
AC A0A1U8K3A7;
DT 10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT 10-MAY-2017, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE SubName: Full=Protein MICRORCHIDIA 2-like isoform X1 {ECO:0000313|RefSeq:XP_016696952.1};
GN Name=LOC107913029 {ECO:0000313|RefSeq:XP_016696952.1};
OS Gossypium hirsutum (Upland cotton) (Gossypium mexicanum).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Malvales; Malvaceae; Malvoideae; Gossypium.
OX NCBI_TaxID=3635 {ECO:0000313|Proteomes:UP000189702, ECO:0000313|RefSeq:XP_016696952.1};
RN [1] {ECO:0000313|Proteomes:UP000189702}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. TM-1 {ECO:0000313|Proteomes:UP000189702};
RX PubMed=25893780; DOI=10.1038/nbt.3208;
RA Li F., Fan G., Lu C., Xiao G., Zou C., Kohel R.J., Ma Z., Shang H., Ma X.,
RA Wu J., Liang X., Huang G., Percy R.G., Liu K., Yang W., Chen W., Du X.,
RA Shi C., Yuan Y., Ye W., Liu X., Zhang X., Liu W., Wei H., Wei S., Huang G.,
RA Zhang X., Zhu S., Zhang H., Sun F., Wang X., Liang J., Wang J., He Q.,
RA Huang L., Wang J., Cui J., Song G., Wang K., Xu X., Yu J.Z., Zhu Y., Yu S.;
RT "Genome sequence of cultivated Upland cotton (Gossypium hirsutum TM-1)
RT provides insights into genome evolution.";
RL Nat. Biotechnol. 33:524-530(2015).
RN [2] {ECO:0000313|RefSeq:XP_016696952.1}
RP IDENTIFICATION.
RC TISSUE=Leaf {ECO:0000313|RefSeq:XP_016696952.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- COFACTOR:
CC Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC Evidence={ECO:0000256|ARBA:ARBA00001936};
CC -!- SIMILARITY: Belongs to the MORC ATPase protein family.
CC {ECO:0000256|ARBA:ARBA00007845}.
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DR RefSeq; XP_016696952.1; XM_016841463.1.
DR AlphaFoldDB; A0A1U8K3A7; -.
DR STRING; 3635.A0A1U8K3A7; -.
DR PaxDb; 3635-A0A1U8K3A7; -.
DR GeneID; 107913029; -.
DR KEGG; ghi:107913029; -.
DR OMA; DWSANLK; -.
DR OrthoDB; 1221114at2759; -.
DR Proteomes; UP000189702; Chromosome 21.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.
DR GO; GO:0031349; P:positive regulation of defense response; IEA:UniProt.
DR GO; GO:0002833; P:positive regulation of response to biotic stimulus; IEA:UniProt.
DR GO; GO:0032103; P:positive regulation of response to external stimulus; IEA:UniProt.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR045261; MORC_ATPase.
DR InterPro; IPR041006; Morc_S5.
DR PANTHER; PTHR23336:SF50; PROTEIN MICRORCHIDIA 1-RELATED; 1.
DR PANTHER; PTHR23336; ZINC FINGER CW-TYPE COILED-COIL DOMAIN PROTEIN 3; 1.
DR Pfam; PF13589; HATPase_c_3; 1.
DR Pfam; PF17942; Morc6_S5; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000189702}.
FT DOMAIN 346..484
FT /note="Morc S5"
FT /evidence="ECO:0000259|Pfam:PF17942"
FT REGION 13..66
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 510..536
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 562..603
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 38..64
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 606 AA; 68061 MW; 7F7A6E2CC44A3C82 CRC64;
MPPKVEKEHL NVVDIASSDD DGDAQTVARK KASSLGERQL RRNISSPEIP QSSGSITPPA
LPSDETLDSR SFWKAGNYVF GPTSKPALLE GALEHARVHP KFLHSNATSH KWAFGAIAEL
MDNAVDEIQH GATFIKVDKI DIKMDNSPGP ALLFLDDGGG MDPVLLRKCM SLGYSSKKSN
TTIGQYGNGF KTSTMRLGAD VIVFSRSTRA GKATQSVGLL SYTFLRRTGQ DDVIVPMIDF
DISGHWAEPI IYSTHDDWSS KLKTILEWSP FSLKEDLLLQ FDDIGPHGTK IIIYNLWLND
EGIYELAFDD DDEDIRLRDE ALREATTKVL KKTVELQSHI SYRLRYSLRA YASMLYLRKF
NNFQIILRGK PVQQFNIADE LQYPKVVTYK PQVAAGSKEC SVETTIGFIK ETPTNVSGFN
VYHKNRLIRP FWKVKSDGSV IGNGVVGVLE ADFIEPAHDK QDFERSSLFV RLENRLKQMV
HEYWKGHCYL MGYQPPGFAA KQKKLLANQH NNSSNLPAGG KQDSRDEQPG LDVPDVVMPE
GDLASISVDQ LCEENIQLFM RCEEKAQKEA DLKQTIEELE KGLEDMRKKC AHLSSLLESK
RKQKVT
//
