ID   A0A1U8K9A0_GOSHI        Unreviewed;       927 AA.
AC   A0A1U8K9A0;
DT   10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT   10-MAY-2017, sequence version 1.
DT   27-MAR-2024, entry version 24.
DE   SubName: Full=Probable transmembrane GTPase FZO-like, chloroplastic {ECO:0000313|RefSeq:XP_016699071.1};
GN   Name=LOC107914624 {ECO:0000313|RefSeq:XP_016699071.1};
OS   Gossypium hirsutum (Upland cotton) (Gossypium mexicanum).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Malvales; Malvaceae; Malvoideae; Gossypium.
OX   NCBI_TaxID=3635 {ECO:0000313|Proteomes:UP000189702, ECO:0000313|RefSeq:XP_016699071.1};
RN   [1] {ECO:0000313|Proteomes:UP000189702}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. TM-1 {ECO:0000313|Proteomes:UP000189702};
RX   PubMed=25893780; DOI=10.1038/nbt.3208;
RA   Li F., Fan G., Lu C., Xiao G., Zou C., Kohel R.J., Ma Z., Shang H., Ma X.,
RA   Wu J., Liang X., Huang G., Percy R.G., Liu K., Yang W., Chen W., Du X.,
RA   Shi C., Yuan Y., Ye W., Liu X., Zhang X., Liu W., Wei H., Wei S., Huang G.,
RA   Zhang X., Zhu S., Zhang H., Sun F., Wang X., Liang J., Wang J., He Q.,
RA   Huang L., Wang J., Cui J., Song G., Wang K., Xu X., Yu J.Z., Zhu Y., Yu S.;
RT   "Genome sequence of cultivated Upland cotton (Gossypium hirsutum TM-1)
RT   provides insights into genome evolution.";
RL   Nat. Biotechnol. 33:524-530(2015).
RN   [2] {ECO:0000313|RefSeq:XP_016699071.1}
RP   IDENTIFICATION.
RC   TISSUE=Leaf {ECO:0000313|RefSeq:XP_016699071.1};
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- PATHWAY: Cofactor biosynthesis; thiamine diphosphate biosynthesis.
CC       {ECO:0000256|ARBA:ARBA00004948}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   RefSeq; XP_016699071.1; XM_016843582.1.
DR   AlphaFoldDB; A0A1U8K9A0; -.
DR   STRING; 3635.A0A1U8K9A0; -.
DR   PaxDb; 3635-A0A1U8K9A0; -.
DR   GeneID; 107914624; -.
DR   KEGG; ghi:107914624; -.
DR   OrthoDB; 9825at2759; -.
DR   Proteomes; UP000189702; Chromosome 3.
DR   GO; GO:0031969; C:chloroplast membrane; IBA:GO_Central.
DR   GO; GO:0005525; F:GTP binding; IEA:InterPro.
DR   GO; GO:0009228; P:thiamine biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0010027; P:thylakoid membrane organization; IBA:GO_Central.
DR   CDD; cd09912; DLP_2; 1.
DR   Gene3D; 3.20.20.70; Aldolase class I; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR006073; GTP-bd.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR005225; Small_GTP-bd_dom.
DR   InterPro; IPR036206; ThiamineP_synth_sf.
DR   InterPro; IPR022998; ThiamineP_synth_TenI.
DR   NCBIfam; TIGR00231; small_GTP; 1.
DR   PANTHER; PTHR43681:SF1; SARCALUMENIN; 1.
DR   PANTHER; PTHR43681; TRANSMEMBRANE GTPASE FZO; 1.
DR   Pfam; PF01926; MMR_HSR1; 1.
DR   Pfam; PF02581; TMP-TENI; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   SUPFAM; SSF51391; Thiamin phosphate synthase; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Membrane {ECO:0000313|RefSeq:XP_016699071.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000189702};
KW   Thiamine biosynthesis {ECO:0000256|ARBA:ARBA00022977};
KW   Transmembrane {ECO:0000313|RefSeq:XP_016699071.1}.
FT   DOMAIN          99..214
FT                   /note="Thiamine phosphate synthase/TenI"
FT                   /evidence="ECO:0000259|Pfam:PF02581"
FT   DOMAIN          374..506
FT                   /note="G"
FT                   /evidence="ECO:0000259|Pfam:PF01926"
FT   REGION          44..75
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          506..533
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          849..910
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        44..71
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   927 AA;  103336 MW;  FC1825C29C3D4352 CRC64;
     MIPLLSLRFP ASPSSALFHF SPSPPFSSRF TKSPFRRFLP PTKPSLSTNS FSSTSQQLGP
     QGPQNQQPPR TLFPGGYKRP EIKVPNFVLQ LDPNDVLADD NALDFIDKAV SKWVGLVVLN
     GGEGSGGRVY EAARSLKAVV KDRAYLLIAE RVDIAAAVGA SGVVLSDQGL PAIIARNTMM
     DSKSDSVFLP LVARTVQSSD SALNASSSEG ADFLIYDLGQ EEHANTAMKA VYENVKIPIF
     VVNNNSQAEV PSYTELTKIF KSGASGVVLS LEDLRLFTDD VLSEFFNTVY TTNNKRQDES
     IVELEMADID RGSHQKVGVA GFIKVEDREK QLIEKERSVL TKAINVFQKA SPLMEEISLL
     IDAVAQIDEP FLLAIVGEFN SGKSTVINAL LGERYLTEGV IPTTNEITFL RYSELDRKDM
     QRCERHPDGQ LICYLPAPIL KEMNIVDTPG TNVILQRQQR LTEEFVPRAD LLFFVISADR
     PLTESEVTFL RYTQQWKKKV VFVLNKSDLY QNMQELEEAI SFIKENTKKL VNTEDVTLYP
     VAARLVLEEK LSATSDVGKK YREIVFAESN WKTSSFYKLE NFLYSFLDGS TSRGMERMKL
     KLGTPIAIAE RILSACETLN RKDCESAEQD LSSANEIIDS VKEYVIKMEN ESISWRRRTL
     SAIDATKSRI LELIESTLQL SNLDVVASFL LKGESSTTLP ATSRIQNEIL GPAIADTQNL
     LGDYVTWLQS NNAREGRAYK ESFEKKWPSI TFSDKNYPLE TYELLRKLDE LSLKAIENLS
     ANATSKQFER EVREVFLETF GGLGAAGLSA SLLTSILPTT LEDLLALGLC SAGGFIAISN
     FPARRQGIIE KVKKTADALG QELEDAMQKD LQETTQNLEK FVRIIGEPYR DAAQNRLDKL
     LEVKDELSNV RGTLKMLQVE IQNLHVS
//