ID A0A1U8KBA0_GOSHI Unreviewed; 776 AA.
AC A0A1U8KBA0;
DT 10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT 10-MAY-2017, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=non-specific serine/threonine protein kinase {ECO:0000256|ARBA:ARBA00012513};
DE EC=2.7.11.1 {ECO:0000256|ARBA:ARBA00012513};
GN Name=LOC107914036 {ECO:0000313|RefSeq:XP_016698243.1};
OS Gossypium hirsutum (Upland cotton) (Gossypium mexicanum).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Malvales; Malvaceae; Malvoideae; Gossypium.
OX NCBI_TaxID=3635 {ECO:0000313|Proteomes:UP000189702, ECO:0000313|RefSeq:XP_016698243.1};
RN [1] {ECO:0000313|Proteomes:UP000189702}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. TM-1 {ECO:0000313|Proteomes:UP000189702};
RX PubMed=25893780; DOI=10.1038/nbt.3208;
RA Li F., Fan G., Lu C., Xiao G., Zou C., Kohel R.J., Ma Z., Shang H., Ma X.,
RA Wu J., Liang X., Huang G., Percy R.G., Liu K., Yang W., Chen W., Du X.,
RA Shi C., Yuan Y., Ye W., Liu X., Zhang X., Liu W., Wei H., Wei S., Huang G.,
RA Zhang X., Zhu S., Zhang H., Sun F., Wang X., Liang J., Wang J., He Q.,
RA Huang L., Wang J., Cui J., Song G., Wang K., Xu X., Yu J.Z., Zhu Y., Yu S.;
RT "Genome sequence of cultivated Upland cotton (Gossypium hirsutum TM-1)
RT provides insights into genome evolution.";
RL Nat. Biotechnol. 33:524-530(2015).
RN [2] {ECO:0000313|RefSeq:XP_016698243.1}
RP IDENTIFICATION.
RC TISSUE=Leaf {ECO:0000313|RefSeq:XP_016698243.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_016698243.1; XM_016842754.1.
DR AlphaFoldDB; A0A1U8KBA0; -.
DR SMR; A0A1U8KBA0; -.
DR STRING; 3635.A0A1U8KBA0; -.
DR PaxDb; 3635-A0A1U8KBA0; -.
DR GeneID; 107914036; -.
DR KEGG; ghi:107914036; -.
DR OrthoDB; 404991at2759; -.
DR Proteomes; UP000189702; Chromosome 22.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0042803; F:protein homodimerization activity; IEA:UniProt.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd14066; STKc_IRAK; 1.
DR Gene3D; 2.130.10.30; Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR044815; CCR1-4.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR InterPro; IPR009091; RCC1/BLIP-II.
DR InterPro; IPR008271; Ser/Thr_kinase_AS.
DR PANTHER; PTHR46146; SERINE/THREONINE-PROTEIN KINASE-LIKE PROTEIN CCR4; 1.
DR PANTHER; PTHR46146:SF4; SERINE_THREONINE-PROTEIN KINASE-LIKE PROTEIN CCR4; 1.
DR Pfam; PF00069; Pkinase; 1.
DR Pfam; PF13540; RCC1_2; 1.
DR SMART; SM00220; S_TKc; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR SUPFAM; SSF50985; RCC1/BLIP-II; 1.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU10141};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|RefSeq:XP_016698243.1};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU10141}; Reference proteome {ECO:0000313|Proteomes:UP000189702};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..27
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 28..776
FT /note="non-specific serine/threonine protein kinase"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5010517772"
FT TRANSMEM 374..397
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 470..758
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT REGION 412..435
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 498
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10141"
SQ SEQUENCE 776 AA; 85865 MW; F6D0CD3270A32983 CRC64;
MGFFFCKSHH FSLFLFSFLC FASFTFSLST VSISETSSLT IVCALVPSNG SLQLYSLNCS
TFPVLDIIET PFSSNDLFSG IVSGDGFLCG LRPSSSSSNV SVMHCWRFSS NGSTLSFKRI
YRGTVINQLE AGNTHICGLN QTNALECWQW PEFNQTGGVQ NFSDIAVGEG FVCGLSEDGT
TIRFLRNFTG ITDRDTIGGN YSVIAAGFRH VCAINSDNDL ECWPNRTTVG DMPQGKFNSL
ALGLNRSCAL RINGTVVCWG MNNFRLPLEL EGLEFITIKA KRNVFCGVLT FNYSLFCWGD
SNFSSNHMVF SEVLPGPCRN ECPYGSLLGS GSLCSNGWSI CQSRPSMPTT PALPPSLSPQ
PQNRSTNNDL NGRLIAFLVV GCVGSSLFLL VVGFFVFRYC KDRVCRVHDS GRLDETGAPV
NGDPESNHPQ TPQAPPAVLE KRLSQLTSMG TTGRLEEFSF EDLVQATNNF SEDHKIGNGS
FGSVYYATLD DGREVAIKRA ETTSTSSYAI GTRRQEDKDD AFVNELEYLS RVHHKNLVRL
WGFYEDSSER ILVYEYMNNG TLHDHLHKLQ NSPFTSWAIR LKIALDAARG IEYLHEYAVP
QIIHRDIKSA NILLDTNWTA KVSDFGLSLM GPGDEESHLS LRAAGTVGYM DPEYYRLQQL
STKSDVYSFG IVLLELLSGY KAIHRNENGA PRNVVDFVVP YILRDEIHRV LDPNVPPPTP
FEIEAVAYVG YLAADCVRPE GRDRPSMTEI VNNLEKALTA CLIPRALSRS TTHSST
//
