ID A0A1U8KH21_GOSHI Unreviewed; 628 AA.
AC A0A1U8KH21;
DT 10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT 10-MAY-2017, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=RING-type E3 ubiquitin transferase {ECO:0000256|ARBA:ARBA00012483};
DE EC=2.3.2.27 {ECO:0000256|ARBA:ARBA00012483};
GN Name=LOC107916877 {ECO:0000313|RefSeq:XP_016701737.1};
OS Gossypium hirsutum (Upland cotton) (Gossypium mexicanum).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Malvales; Malvaceae; Malvoideae; Gossypium.
OX NCBI_TaxID=3635 {ECO:0000313|Proteomes:UP000189702, ECO:0000313|RefSeq:XP_016701737.1};
RN [1] {ECO:0000313|Proteomes:UP000189702}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. TM-1 {ECO:0000313|Proteomes:UP000189702};
RX PubMed=25893780; DOI=10.1038/nbt.3208;
RA Li F., Fan G., Lu C., Xiao G., Zou C., Kohel R.J., Ma Z., Shang H., Ma X.,
RA Wu J., Liang X., Huang G., Percy R.G., Liu K., Yang W., Chen W., Du X.,
RA Shi C., Yuan Y., Ye W., Liu X., Zhang X., Liu W., Wei H., Wei S., Huang G.,
RA Zhang X., Zhu S., Zhang H., Sun F., Wang X., Liang J., Wang J., He Q.,
RA Huang L., Wang J., Cui J., Song G., Wang K., Xu X., Yu J.Z., Zhu Y., Yu S.;
RT "Genome sequence of cultivated Upland cotton (Gossypium hirsutum TM-1)
RT provides insights into genome evolution.";
RL Nat. Biotechnol. 33:524-530(2015).
RN [2] {ECO:0000313|RefSeq:XP_016701737.1}
RP IDENTIFICATION.
RC TISSUE=Leaf {ECO:0000313|RefSeq:XP_016701737.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine +
CC [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-
CC cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.;
CC EC=2.3.2.27; Evidence={ECO:0000256|ARBA:ARBA00000900};
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC {ECO:0000256|ARBA:ARBA00004906}.
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DR RefSeq; XP_016701737.1; XM_016846248.1.
DR AlphaFoldDB; A0A1U8KH21; -.
DR GeneID; 107916877; -.
DR OrthoDB; 458417at2759; -.
DR UniPathway; UPA00143; -.
DR Proteomes; UP000189702; Chromosome 23.
DR GO; GO:0004842; F:ubiquitin-protein transferase activity; IEA:InterPro.
DR GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR CDD; cd16664; RING-Ubox_PUB; 1.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR045210; RING-Ubox_PUB.
DR InterPro; IPR003613; Ubox_domain.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR23315:SF239; RING-TYPE E3 UBIQUITIN TRANSFERASE; 1.
DR PANTHER; PTHR23315; U BOX DOMAIN-CONTAINING; 1.
DR Pfam; PF04564; U-box; 1.
DR SMART; SM00504; Ubox; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR PROSITE; PS51698; U_BOX; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000189702};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786}.
FT DOMAIN 139..213
FT /note="U-box"
FT /evidence="ECO:0000259|PROSITE:PS51698"
SQ SEQUENCE 628 AA; 70173 MW; 507E2E0B09EBBF88 CRC64;
MIAGIIDELR SARFQLEASE HEAGAAIIVL LEHDKSASAS RKQSEIEALR LSSLRLSITS
PFALLIEKRS IKKLLGSVQD TNPNKRKVLT YLLYLLKKHG KLIWQLQPKR TEEESLFSLM
KEDGDENDET SGYDFFLPIT PDQIICPISK RLLYDPVIIA SGQTFERVWI EKWFNEGNQM
CPVTNTKLMQ FSLTPNLAMK ALISKWLLRH GINVPQHVKP VPSLLSLRQP SSCSIASFGT
SVLGFRLEMG SVTLDPVSTD SSLDFSDGKS NDEIKSMLPQ AAADSHHRIH HHQLSTDGIR
VVCLSELDKH SWISQCKAVQ NVKGLIEDKD EAQRLTFSNS QVVPVIKFLK DAKDLCDVKM
QKVGAEVLLA ILSGCRIELP LCHEDVIYLL ASLLDSETAR ECLAILEILS WQQYYKSRIV
ACGILPSILK LLDTTVTEFN MLALKILWNL SNGSNVGYHI TYLGYIPKLV SSLEDPNVAG
YCVGIINNIR DIEEARIEAV EAGLCTSIAT ILESSKKEEQ EVGVELLLFL CYENTGYCKM
IMTENIIQAL SNISVNGSSK GSENALTLLE LMDWMNASQC SRSGSRWSQE NSNVSSSTSN
NSRLKISSYK TLGCLRKKLS RFLWNVLH
//
