ID A0A1U8KHV9_GOSHI Unreviewed; 318 AA.
AC A0A1U8KHV9;
DT 10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT 10-MAY-2017, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Bifunctional nuclease 2-like {ECO:0000313|RefSeq:XP_016702136.1};
GN Name=LOC107917246 {ECO:0000313|RefSeq:XP_016702136.1};
OS Gossypium hirsutum (Upland cotton) (Gossypium mexicanum).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Malvales; Malvaceae; Malvoideae; Gossypium.
OX NCBI_TaxID=3635 {ECO:0000313|Proteomes:UP000189702, ECO:0000313|RefSeq:XP_016702136.1};
RN [1] {ECO:0000313|Proteomes:UP000189702}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. TM-1 {ECO:0000313|Proteomes:UP000189702};
RX PubMed=25893780; DOI=10.1038/nbt.3208;
RA Li F., Fan G., Lu C., Xiao G., Zou C., Kohel R.J., Ma Z., Shang H., Ma X.,
RA Wu J., Liang X., Huang G., Percy R.G., Liu K., Yang W., Chen W., Du X.,
RA Shi C., Yuan Y., Ye W., Liu X., Zhang X., Liu W., Wei H., Wei S., Huang G.,
RA Zhang X., Zhu S., Zhang H., Sun F., Wang X., Liang J., Wang J., He Q.,
RA Huang L., Wang J., Cui J., Song G., Wang K., Xu X., Yu J.Z., Zhu Y., Yu S.;
RT "Genome sequence of cultivated Upland cotton (Gossypium hirsutum TM-1)
RT provides insights into genome evolution.";
RL Nat. Biotechnol. 33:524-530(2015).
RN [2] {ECO:0000313|RefSeq:XP_016702136.1}
RP IDENTIFICATION.
RC TISSUE=Leaf {ECO:0000313|RefSeq:XP_016702136.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Bifunctional nuclease with both RNase and DNase activities.
CC Involved in basal defense response. Participates in abscisic acid-
CC derived callose deposition following infection by a necrotrophic
CC pathogen. {ECO:0000256|ARBA:ARBA00025428}.
CC -!- SIMILARITY: Belongs to the bifunctional nuclease family.
CC {ECO:0000256|ARBA:ARBA00009095}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_016702136.1; XM_016846647.1.
DR AlphaFoldDB; A0A1U8KHV9; -.
DR STRING; 3635.A0A1U8KHV9; -.
DR PaxDb; 3635-A0A1U8KHV9; -.
DR GeneID; 107917246; -.
DR KEGG; ghi:107917246; -.
DR OrthoDB; 304718at2759; -.
DR Proteomes; UP000189702; Chromosome 1.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0030891; C:VCB complex; IBA:GO_Central.
DR GO; GO:0004518; F:nuclease activity; IEA:UniProtKB-UniRule.
DR GO; GO:0016567; P:protein ubiquitination; IBA:GO_Central.
DR Gene3D; 3.10.690.10; Bifunctional nuclease domain; 1.
DR InterPro; IPR036104; BFN_sf.
DR InterPro; IPR003729; Bi_nuclease_dom.
DR PANTHER; PTHR15160:SF1; VON HIPPEL-LINDAU DISEASE TUMOR SUPPRESSOR; 1.
DR PANTHER; PTHR15160; VON HIPPEL-LINDAU PROTEIN; 1.
DR Pfam; PF02577; BFN_dom; 1.
DR SUPFAM; SSF103256; Hypothetical protein TM0160; 1.
DR PROSITE; PS51658; BFN; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000189702}.
FT DOMAIN 114..251
FT /note="BFN"
FT /evidence="ECO:0000259|PROSITE:PS51658"
SQ SEQUENCE 318 AA; 36139 MW; 51D4B1834769B616 CRC64;
MLGVQLCYRT FSTFWVFSHK SNATTCPTIP AFSFPSIRSS SIRLHFTAKL RPVSCHSIRS
GSFDPQFNED DDKDLQFLEA SLLVSETVSH YRMLRQGIKE EIKWQSSRRE QHPMSRAKIA
SIGQSFLSRF PTPTIFLKIS CDGDFLLPII VGEFAVEKLI ASFSGDDKGE CPDQFHLVKN
VVEKLGYEVK MVRITERVVN TYFAKLYFSK PGENDVISVD ARPSDAINVA HRCKAPIYVS
KQIVLEDAIR IGFGMGRVRD TTPTYDVVLD SAMEGPDLLT EELHLVRNMN LAVEEERYND
AAMLRDKLMK LRNSSHDQ
//
