ID A0A1U8KMY4_GOSHI Unreviewed; 555 AA.
AC A0A1U8KMY4;
DT 10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT 10-MAY-2017, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE RecName: Full=(+)-delta-cadinene synthase {ECO:0000256|ARBA:ARBA00013103};
DE EC=4.2.3.13 {ECO:0000256|ARBA:ARBA00013103};
GN Name=LOC107918736 {ECO:0000313|RefSeq:XP_016703812.1};
OS Gossypium hirsutum (Upland cotton) (Gossypium mexicanum).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Malvales; Malvaceae; Malvoideae; Gossypium.
OX NCBI_TaxID=3635 {ECO:0000313|Proteomes:UP000189702, ECO:0000313|RefSeq:XP_016703812.1};
RN [1] {ECO:0000313|Proteomes:UP000189702}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. TM-1 {ECO:0000313|Proteomes:UP000189702};
RX PubMed=25893780; DOI=10.1038/nbt.3208;
RA Li F., Fan G., Lu C., Xiao G., Zou C., Kohel R.J., Ma Z., Shang H., Ma X.,
RA Wu J., Liang X., Huang G., Percy R.G., Liu K., Yang W., Chen W., Du X.,
RA Shi C., Yuan Y., Ye W., Liu X., Zhang X., Liu W., Wei H., Wei S., Huang G.,
RA Zhang X., Zhu S., Zhang H., Sun F., Wang X., Liang J., Wang J., He Q.,
RA Huang L., Wang J., Cui J., Song G., Wang K., Xu X., Yu J.Z., Zhu Y., Yu S.;
RT "Genome sequence of cultivated Upland cotton (Gossypium hirsutum TM-1)
RT provides insights into genome evolution.";
RL Nat. Biotechnol. 33:524-530(2015).
RN [2] {ECO:0000313|RefSeq:XP_016703812.1}
RP IDENTIFICATION.
RC TISSUE=Leaf {ECO:0000313|RefSeq:XP_016703812.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Responsible for the cyclization of trans,trans-farnesyl
CC diphosphate (FPP) to (+)-delta cadinene.
CC {ECO:0000256|ARBA:ARBA00002383}.
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|ARBA:ARBA00001946};
CC -!- PATHWAY: Secondary metabolite biosynthesis; terpenoid biosynthesis.
CC {ECO:0000256|ARBA:ARBA00004721}.
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DR RefSeq; XP_016703812.1; XM_016848323.1.
DR AlphaFoldDB; A0A1U8KMY4; -.
DR STRING; 3635.A0A1U8KMY4; -.
DR PaxDb; 3635-A0A1U8KMY4; -.
DR GeneID; 107918736; -.
DR KEGG; ghi:107918736; -.
DR OrthoDB; 1209509at2759; -.
DR Proteomes; UP000189702; Chromosome 24.
DR GO; GO:0047461; F:(+)-delta-cadinene synthase activity; IEA:UniProtKB-EC.
DR GO; GO:0000287; F:magnesium ion binding; IEA:InterPro.
DR GO; GO:0016102; P:diterpenoid biosynthetic process; IEA:InterPro.
DR CDD; cd00684; Terpene_cyclase_plant_C1; 1.
DR Gene3D; 1.10.600.10; Farnesyl Diphosphate Synthase; 1.
DR Gene3D; 1.50.10.130; Terpene synthase, N-terminal domain; 1.
DR InterPro; IPR008949; Isoprenoid_synthase_dom_sf.
DR InterPro; IPR034741; Terpene_cyclase-like_1_C.
DR InterPro; IPR044814; Terpene_cyclase_plant_C1.
DR InterPro; IPR001906; Terpene_synth_N.
DR InterPro; IPR036965; Terpene_synth_N_sf.
DR InterPro; IPR005630; Terpene_synthase_metal-bd.
DR InterPro; IPR008930; Terpenoid_cyclase/PrenylTrfase.
DR PANTHER; PTHR31225:SF215; (+)-DELTA-CADINENE SYNTHASE; 1.
DR PANTHER; PTHR31225; OS04G0344100 PROTEIN-RELATED; 1.
DR Pfam; PF01397; Terpene_synth; 1.
DR Pfam; PF03936; Terpene_synth_C; 1.
DR SFLD; SFLDS00005; Isoprenoid_Synthase_Type_I; 1.
DR SFLD; SFLDG01019; Terpene_Cyclase_Like_1_C_Termi; 1.
DR SUPFAM; SSF48239; Terpenoid cyclases/Protein prenyltransferases; 1.
DR SUPFAM; SSF48576; Terpenoid synthases; 1.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000189702}.
FT DOMAIN 32..202
FT /note="Terpene synthase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF01397"
FT DOMAIN 259..498
FT /note="Terpene synthase metal-binding"
FT /evidence="ECO:0000259|Pfam:PF03936"
FT REGION 1..25
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..19
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 555 AA; 64909 MW; F47342AEA749408C CRC64;
MASQVSQKLS SSPFSSNKDE MRPKFNIPPP SIWGDVFLNC PDKNIDAETE KHHQQLKEEV
RKMIVAPMAN STQKLPFIDS VQRLGVSYHF TKEIEDELEN IYHNDNDAEN DLYTTSLRFR
LLREHGFNVS CEVFNKFKDE QGNFKSSVTS DVRGLLELYE ASYMRVHGED ILDEAISFTT
NHLSLVVASL DYPLSEQVSH ALKQSIRRGL PRVEARHYLS VYQDMESHNK SLLEFAKIDF
NMLQLLHRKE ISEICRWWKD LDFKRKLPYA RDRVVECYFW ILGVYFEPQY SLGRKMTTKV
LAMASHLDDT YDSYATYDEL IIYRSAIERW EIKCIDQLPE YMKLNYKALL DVYEEMEQLV
AEHGRQYCVE YAKNAMIQLL QFYFMEAKWA LQNYKPSFEE FKANAVSSSG YAMLAITSFA
GMGDMITPKT FKWAVSNPKI IEASTIICRF TDDVTEHKFK HRREDEWSTI DYYMKEYGAT
AQEAYDVFNK HIESAWKDTN QEFLKPREMP IEVLNRSLNL SRVMDVLDKD GDGYTHVTKP
IKDAITSLLI EPITL
//
