ID A0A1U8KN20_GOSHI Unreviewed; 1242 AA.
AC A0A1U8KN20;
DT 10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT 10-MAY-2017, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=RNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00012493};
DE EC=2.7.7.49 {ECO:0000256|ARBA:ARBA00012493};
GN Name=LOC107917259 {ECO:0000313|RefSeq:XP_016702119.1};
OS Gossypium hirsutum (Upland cotton) (Gossypium mexicanum).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Malvales; Malvaceae; Malvoideae; Gossypium.
OX NCBI_TaxID=3635 {ECO:0000313|Proteomes:UP000189702, ECO:0000313|RefSeq:XP_016702119.1};
RN [1] {ECO:0000313|Proteomes:UP000189702}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. TM-1 {ECO:0000313|Proteomes:UP000189702};
RX PubMed=25893780; DOI=10.1038/nbt.3208;
RA Li F., Fan G., Lu C., Xiao G., Zou C., Kohel R.J., Ma Z., Shang H., Ma X.,
RA Wu J., Liang X., Huang G., Percy R.G., Liu K., Yang W., Chen W., Du X.,
RA Shi C., Yuan Y., Ye W., Liu X., Zhang X., Liu W., Wei H., Wei S., Huang G.,
RA Zhang X., Zhu S., Zhang H., Sun F., Wang X., Liang J., Wang J., He Q.,
RA Huang L., Wang J., Cui J., Song G., Wang K., Xu X., Yu J.Z., Zhu Y., Yu S.;
RT "Genome sequence of cultivated Upland cotton (Gossypium hirsutum TM-1)
RT provides insights into genome evolution.";
RL Nat. Biotechnol. 33:524-530(2015).
RN [2] {ECO:0000313|RefSeq:XP_016702119.1}
RP IDENTIFICATION.
RC TISSUE=Leaf {ECO:0000313|RefSeq:XP_016702119.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_016702119.1; XM_016846630.1.
DR AlphaFoldDB; A0A1U8KN20; -.
DR PaxDb; 3635-A0A1U8KN20; -.
DR Proteomes; UP000189702; Chromosome 23.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0004523; F:RNA-DNA hybrid ribonuclease activity; IEA:InterPro.
DR GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
DR CDD; cd00303; retropepsin_like; 1.
DR CDD; cd09279; RNase_HI_like; 1.
DR CDD; cd09274; RNase_HI_RT_Ty3; 1.
DR CDD; cd01647; RT_LTR; 1.
DR Gene3D; 3.10.20.370; -; 1.
DR Gene3D; 3.30.70.270; -; 2.
DR Gene3D; 2.40.70.10; Acid Proteases; 1.
DR Gene3D; 3.10.10.10; HIV Type 1 Reverse Transcriptase, subunit A, domain 1; 1.
DR Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR021109; Peptidase_aspartic_dom_sf.
DR InterPro; IPR005162; Retrotrans_gag_dom.
DR InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR002156; RNaseH_domain.
DR InterPro; IPR036397; RNaseH_sf.
DR InterPro; IPR000477; RT_dom.
DR InterPro; IPR041373; RT_RNaseH.
DR PANTHER; PTHR32108; DNA-DIRECTED RNA POLYMERASE SUBUNIT ALPHA; 1.
DR PANTHER; PTHR32108:SF5; G-PATCH DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF03732; Retrotrans_gag; 1.
DR Pfam; PF17917; RT_RNaseH; 1.
DR Pfam; PF00078; RVT_1; 1.
DR Pfam; PF13456; RVT_3; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR PROSITE; PS50879; RNASE_H_1; 1.
PE 4: Predicted;
KW DNA recombination {ECO:0000256|ARBA:ARBA00023172};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000189702}.
FT DOMAIN 1114..1242
FT /note="RNase H type-1"
FT /evidence="ECO:0000259|PROSITE:PS50879"
FT NON_TER 1
FT /evidence="ECO:0000313|RefSeq:XP_016702119.1"
FT NON_TER 1242
FT /evidence="ECO:0000313|RefSeq:XP_016702119.1"
SQ SEQUENCE 1242 AA; 141625 MW; 168828FAA01B31D3 CRC64;
SLVPDLVLPP KFKMPEFEKY NGTSCPEAHI TMFCRRMTGY VNNDQLLIHC FQDSLIGSAA
KWYNQLSRAK VSSWRDLAQA FMKQYSHVTD ITPDRITLQN MEKKPSENFR QYAQRWREVA
TQVQPPLLEK EVTMLFINTL KAPFINHMLG SATKSFSDMV MSGEMIENAV RSGKIDTGES
FKRPAPRKKE GEVNNLKFLK HSEYSVVEQL HKQPARISVL ELLLSSEIHR NALVKVLNET
YVAKDISVNK LDRLVNNINA DNFIFFNDDE IPPGGMGSTK ALHITARCKG CILPAVLVDN
GSALNVLPLS TLNRLPVDSS HMKSCQNIVR AFDGTERKVM GRIEIPLLIG PNTYEVDFLV
MDIKPSYNCL LGRPWIHSAG AVPSSLHQKL KLVMEGRLVT IGAEEDIIAS VTDDMPYIEA
DSEAIECSFR SLEFVNATFV IEMSKIPEPK ISKATSMSLQ LTMGKGALPG RGLGKYLQGR
VGVPILVNKQ DRYGLGYKPN AVERRKEMER KQEKRRAHLS GIEAKWGPIT FPHISKTFVS
RGIVYPEEKD EVTEGRIERL DINAISAEER VERNLSGIRP CKPGSLRMME EEEKQILPYK
ESVEVVILEE GREVKVGACI AKETRRDLVE LLQEFKDVFA WSYQDMPGLS TDIMVHRLPI
KEECKPVQQK LRRMRPDVLL KIKEEVKKQF DAGFLQVVKY SEWVANIVPV PKKDGKVRMC
VDYRDLNKAS PKDNFPLPHI DTLVDNTAGY SLFSFMDGFS GYNQIKMLSE DKEKTTFITM
WGTFCYKVMP FGLKNAGATY QRAMVALFHD MMHKEIEVYV DDMIAKSRTE REHVQVLRKL
FLRLRKFQLK LNPAKCTFGA RSGKLLGFLV SEKGIEIDPD KVKAIQELPP PSTQKEVRGF
LGRLNYIARF ISQLTEKCDP IFRLLRKHNP GVWDEECQKT FERVKHYLSN APVLMPPSPD
KPLILYLAVF ENSMGCVLGQ HDKSGRKERA IYYLSKKFTE CETRYSPIEK LCCALVWTTR
RLRQYMLYHT TWLISKLDPL KYMMESTALN GRMARWQILL SEFDITYVNQ KAVKGSAIAD
FLASRALDDY EPLNFDFPNE DLMYVATTEA STQEGNTWKL NFDGASNAMG NGIGAVLVSP
NGDHYPFTSK LDFDCTNNMA EYEACIMGIR AAMERKIKVL EVYGDSALVI YQLKGEWETR
DPKLISYRRI VLELIEEFDD ITFCYLPRDE NQMADALATL AS
//
