ID A0A1U8KQY7_GOSHI Unreviewed; 1263 AA.
AC A0A1U8KQY7;
DT 10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT 10-MAY-2017, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE SubName: Full=Regulator of nonsense transcripts 1 homolog {ECO:0000313|RefSeq:XP_016704850.1};
GN Name=LOC107919919 {ECO:0000313|RefSeq:XP_016704850.1};
OS Gossypium hirsutum (Upland cotton) (Gossypium mexicanum).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Malvales; Malvaceae; Malvoideae; Gossypium.
OX NCBI_TaxID=3635 {ECO:0000313|Proteomes:UP000189702, ECO:0000313|RefSeq:XP_016704850.1};
RN [1] {ECO:0000313|Proteomes:UP000189702}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. TM-1 {ECO:0000313|Proteomes:UP000189702};
RX PubMed=25893780; DOI=10.1038/nbt.3208;
RA Li F., Fan G., Lu C., Xiao G., Zou C., Kohel R.J., Ma Z., Shang H., Ma X.,
RA Wu J., Liang X., Huang G., Percy R.G., Liu K., Yang W., Chen W., Du X.,
RA Shi C., Yuan Y., Ye W., Liu X., Zhang X., Liu W., Wei H., Wei S., Huang G.,
RA Zhang X., Zhu S., Zhang H., Sun F., Wang X., Liang J., Wang J., He Q.,
RA Huang L., Wang J., Cui J., Song G., Wang K., Xu X., Yu J.Z., Zhu Y., Yu S.;
RT "Genome sequence of cultivated Upland cotton (Gossypium hirsutum TM-1)
RT provides insights into genome evolution.";
RL Nat. Biotechnol. 33:524-530(2015).
RN [2] {ECO:0000313|RefSeq:XP_016704850.1}
RP IDENTIFICATION.
RC TISSUE=Leaf {ECO:0000313|RefSeq:XP_016704850.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
CC Evidence={ECO:0000256|ARBA:ARBA00000600};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:13066;
CC Evidence={ECO:0000256|ARBA:ARBA00000600};
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- SIMILARITY: Belongs to the DNA2/NAM7 helicase family.
CC {ECO:0000256|ARBA:ARBA00007913}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU01341}.
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DR RefSeq; XP_016704850.1; XM_016849361.1.
DR AlphaFoldDB; A0A1U8KQY7; -.
DR STRING; 3635.A0A1U8KQY7; -.
DR PaxDb; 3635-A0A1U8KQY7; -.
DR GeneID; 107919919; -.
DR KEGG; ghi:107919919; -.
DR OrthoDB; 170190at2759; -.
DR Proteomes; UP000189702; Chromosome 24.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR GO; GO:0003724; F:RNA helicase activity; IBA:GO_Central.
DR GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0000184; P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; IBA:GO_Central.
DR CDD; cd21407; 1B_UPF1-like; 1.
DR CDD; cd18039; DEXXQc_UPF1; 1.
DR CDD; cd18808; SF1_C_Upf1; 1.
DR CDD; cd21400; ZBD_UPF1-like; 1.
DR Gene3D; 2.40.30.230; -; 1.
DR Gene3D; 6.10.140.1240; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR045055; DNA2/NAM7-like.
DR InterPro; IPR041679; DNA2/NAM7-like_C.
DR InterPro; IPR041677; DNA2/NAM7_AAA_11.
DR InterPro; IPR006935; Helicase/UvrB_N.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR047187; SF1_C_Upf1.
DR InterPro; IPR040812; UPF1_1B_dom.
DR InterPro; IPR018999; UPF1_CH/ZBD.
DR PANTHER; PTHR10887; DNA2/NAM7 HELICASE FAMILY; 1.
DR PANTHER; PTHR10887:SF364; REGULATOR OF NONSENSE TRANSCRIPTS 1; 1.
DR Pfam; PF13086; AAA_11; 1.
DR Pfam; PF13087; AAA_12; 1.
DR Pfam; PF04851; ResIII; 1.
DR Pfam; PF18141; UPF1_1B_dom; 1.
DR Pfam; PF09416; UPF1_Zn_bind; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51997; UPF1_CH_RICH; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723, ECO:0000256|PROSITE-
KW ProRule:PRU01341}; Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000189702};
KW Zinc {ECO:0000256|PROSITE-ProRule:PRU01341};
KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU01341}.
FT DOMAIN 125..284
FT /note="Upf1"
FT /evidence="ECO:0000259|PROSITE:PS51997"
FT DOMAIN 490..622
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT REGION 1..89
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 195..225
FT /note="C4"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01341"
FT REGION 949..995
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1046..1065
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1188..1215
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1232..1263
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..30
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 61..89
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 951..965
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1050..1065
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1263 AA; 138695 MW; 6FD6B8BA387BAC0E CRC64;
MDSQFETASQ PDPATDAYTF LEFNTQGESD FEYTDFRDPI RSWPTPSDAH SAERSGSDHH
SDTAASSSPS SASKGAGRGV ASNNNSHSNS ISNSAAVVDA LATGIGGLNF EETVGDEDGG
YDYGKGDFAE HSCRYCGVSN PACVVRCNVP SCRKWFCNSR GNTSGSHIVN HLVRSKHKEV
CLHKDSPLGE TILECYNCGC RNVFLLGFIS AKTESVVVLL CREPCLNVNA LKDMNWDLSQ
WCPLIDDRCF LQWLVKIPSE QEQLRARQIS AQQINKVEEL WKTNPDASFE DLEKPGVDDE
PQPVALKYED AYQYQNVFAP LIKLEADYDK MMKESQSKDN VTVRWDIGLN KKRIAYFVFP
KEDNELRLVP GDELRLRYSG DAAHPAWQAV GHVIKLTAQE EVALELRASQ GVPIDVNHGF
SVDFVWKSTS FDRMQGAMKT FAVDETSVSG YIYHHLLGHE VEVQMVRNTL PRRFGAPGLP
ELNASQVFAV KSVLQKPISL IQGPPGTGKT VTSAAIVYHM AKQGQGQVLV CAPSNVAVDQ
LAEKISTTGL KVVRLCAKSR EAVSSPVEHL TLHYQVRHLD TSEKSELHKL QQLKDEQGEL
SSSDEKKYKA LKRATEREIS QSADVICCTC VGAADPRLAN FRFRQVLIDE STQATEPECL
IPLVLGVKQV VLVGDHCQLG PVIMCKKAAR AGLAQSLFER LVLLGVKPIR LQVQYRMHPC
LSEFPSNSFY EGTLQNGVTI NERQSSGIDF PWPVPNRPMF FYVQMGQEEI SASGTSYLNR
TEAANVEKIV TTFLRSGVVP SQIGVITPYE GQRAYIVNYM SRNGSLRQQL YKEIEVASVD
SFQGREKDYI IVSCVRSNEH QGIGFLNDPR RLNVALTRAR YGIVILGNPK VLSKQPLWNG
LLTHYKENEC LVEGPLNNLK QSMVQFQKPK KIYNERRLFF GGGPGILPND NFGDASSSPN
VDRRSSRARG TYMPSGPPNG THKPGVHPTG FPMPRVPLPP FPGSPSQPYA IPSRGAVHGP
VGAVPQVPQP GSRGFGVGRG NASAPIGHHL PHQQGSQQNV GTIGSPFNFP PLENPNSQPS
VGGPLSQPGF VNNMPVQGAS QTIRDGFSMG GMSQDFLGED FKSQGSHVPY NIADFSTQGG
YAVDYASQGA QSGFPGNFLN QNSQAGYSRF GAGNDFMTQD YMNHGSQGLF TQAGFNDPSQ
DDASQSHFGA ANPNQLQSQG LMNSLYSQPF AHYNTQPLNL QSPQQQQPQQ GQGSQNQNLR
YNG
//
