ID A0A1U8KRR0_GOSHI Unreviewed; 545 AA.
AC A0A1U8KRR0;
DT 10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT 10-MAY-2017, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE RecName: Full=apyrase {ECO:0000256|ARBA:ARBA00012148};
DE EC=3.6.1.5 {ECO:0000256|ARBA:ARBA00012148};
DE AltName: Full=ATP-diphosphatase {ECO:0000256|ARBA:ARBA00031428};
DE AltName: Full=ATP-diphosphohydrolase {ECO:0000256|ARBA:ARBA00032306};
DE AltName: Full=Adenosine diphosphatase {ECO:0000256|ARBA:ARBA00030084};
DE AltName: Full=NTPDase {ECO:0000256|ARBA:ARBA00031370};
GN Name=LOC107920112 {ECO:0000313|RefSeq:XP_016705130.1};
OS Gossypium hirsutum (Upland cotton) (Gossypium mexicanum).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Malvales; Malvaceae; Malvoideae; Gossypium.
OX NCBI_TaxID=3635 {ECO:0000313|Proteomes:UP000189702, ECO:0000313|RefSeq:XP_016705130.1};
RN [1] {ECO:0000313|Proteomes:UP000189702}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. TM-1 {ECO:0000313|Proteomes:UP000189702};
RX PubMed=25893780; DOI=10.1038/nbt.3208;
RA Li F., Fan G., Lu C., Xiao G., Zou C., Kohel R.J., Ma Z., Shang H., Ma X.,
RA Wu J., Liang X., Huang G., Percy R.G., Liu K., Yang W., Chen W., Du X.,
RA Shi C., Yuan Y., Ye W., Liu X., Zhang X., Liu W., Wei H., Wei S., Huang G.,
RA Zhang X., Zhu S., Zhang H., Sun F., Wang X., Liang J., Wang J., He Q.,
RA Huang L., Wang J., Cui J., Song G., Wang K., Xu X., Yu J.Z., Zhu Y., Yu S.;
RT "Genome sequence of cultivated Upland cotton (Gossypium hirsutum TM-1)
RT provides insights into genome evolution.";
RL Nat. Biotechnol. 33:524-530(2015).
RN [2] {ECO:0000313|RefSeq:XP_016705130.1}
RP IDENTIFICATION.
RC TISSUE=Leaf {ECO:0000313|RefSeq:XP_016705130.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a ribonucleoside 5'-triphosphate + 2 H2O = a ribonucleoside
CC 5'-phosphate + 2 H(+) + 2 phosphate; Xref=Rhea:RHEA:36795,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:43474,
CC ChEBI:CHEBI:58043, ChEBI:CHEBI:61557; EC=3.6.1.5;
CC Evidence={ECO:0000256|ARBA:ARBA00000211};
CC -!- SIMILARITY: Belongs to the GDA1/CD39 NTPase family.
CC {ECO:0000256|ARBA:ARBA00009283}.
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DR RefSeq; XP_016705130.1; XM_016849641.1.
DR AlphaFoldDB; A0A1U8KRR0; -.
DR STRING; 3635.A0A1U8KRR0; -.
DR PaxDb; 3635-A0A1U8KRR0; -.
DR GeneID; 107920112; -.
DR KEGG; ghi:107920112; -.
DR OrthoDB; 180318at2759; -.
DR Proteomes; UP000189702; Chromosome 24.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0004050; F:apyrase activity; IEA:UniProtKB-EC.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0017110; F:nucleoside diphosphate phosphatase activity; IBA:GO_Central.
DR GO; GO:0009134; P:nucleoside diphosphate catabolic process; IBA:GO_Central.
DR CDD; cd00012; NBD_sugar-kinase_HSP70_actin; 1.
DR Gene3D; 3.30.420.40; -; 1.
DR Gene3D; 3.30.420.150; Exopolyphosphatase. Domain 2; 1.
DR InterPro; IPR000407; GDA1_CD39_NTPase.
DR PANTHER; PTHR11782; ADENOSINE/GUANOSINE DIPHOSPHATASE; 1.
DR PANTHER; PTHR11782:SF3; APYRASE 6-RELATED; 1.
DR Pfam; PF01150; GDA1_CD39; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|PIRSR:PIRSR600407-2};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|PIRSR:PIRSR600407-2};
KW Reference proteome {ECO:0000313|Proteomes:UP000189702};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 50..72
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 500..518
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 1..26
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 206
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR600407-1"
FT BINDING 236..240
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PIRSR:PIRSR600407-2"
SQ SEQUENCE 545 AA; 61437 MW; A836B794F35ED201 CRC64;
MRRSHARNRV ESKSKSTTNP QKMDPIKLQI RSNSRSTALF SRNSRQTKPI PSFIAVSIAI
SLALFAFIYI VFFSSKGSVK YGIIIDGGST GTRIHVIRYR VDGGKNPVFD FKEGLDSLRV
NPGLSAYAED LAGAGYSLKE LLEFARRKVP KKQWGETEIR LMATAGMRLL DDEVQERILE
QLRKVLRVSG FKFRDDWASI ITGSDEGVYA WVVANYVLGT LGGNPLHTTG IIELGGASAQ
VTFFSNEPMP SEFSRSIKFG NITYSLYSHS FLHFGQNVAH ESLRASLVKG DFSPAADSLR
KEMYIDPCTP KGYFPESSNL SLGSVAEKSK YISEFKARGN FSECRSAALT QLQKGKERCS
YDHCYLGSVF MPKLRGKFFA TENFFYTSKF FRLRQRAFLS DLIMAGKHFC EEDWSKLKKK
HQSLNEEDLL RYCFSSAYFV ALLHDSLEIA LDDERISFAN QVNDIPLDWA LGAFILQSTS
ISDVQQTDWI TIIMSSDSST LISITAISAI LMFAAWSISK WRKPQLKTVY DLEKGRYIVT
RIGRS
//