ID A0A1U8KYY6_GOSHI Unreviewed; 831 AA.
AC A0A1U8KYY6;
DT 10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT 10-MAY-2017, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=Rho GTPase-activating protein REN1-like isoform X2 {ECO:0000313|RefSeq:XP_016706283.1, ECO:0000313|RefSeq:XP_016706285.1};
GN Name=LOC107920961 {ECO:0000313|RefSeq:XP_016706283.1,
GN ECO:0000313|RefSeq:XP_016706285.1, ECO:0000313|RefSeq:XP_016706286.1};
OS Gossypium hirsutum (Upland cotton) (Gossypium mexicanum).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Malvales; Malvaceae; Malvoideae; Gossypium.
OX NCBI_TaxID=3635 {ECO:0000313|Proteomes:UP000189702, ECO:0000313|RefSeq:XP_016706283.1};
RN [1] {ECO:0000313|Proteomes:UP000189702}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. TM-1 {ECO:0000313|Proteomes:UP000189702};
RX PubMed=25893780; DOI=10.1038/nbt.3208;
RA Li F., Fan G., Lu C., Xiao G., Zou C., Kohel R.J., Ma Z., Shang H., Ma X.,
RA Wu J., Liang X., Huang G., Percy R.G., Liu K., Yang W., Chen W., Du X.,
RA Shi C., Yuan Y., Ye W., Liu X., Zhang X., Liu W., Wei H., Wei S., Huang G.,
RA Zhang X., Zhu S., Zhang H., Sun F., Wang X., Liang J., Wang J., He Q.,
RA Huang L., Wang J., Cui J., Song G., Wang K., Xu X., Yu J.Z., Zhu Y., Yu S.;
RT "Genome sequence of cultivated Upland cotton (Gossypium hirsutum TM-1)
RT provides insights into genome evolution.";
RL Nat. Biotechnol. 33:524-530(2015).
RN [2] {ECO:0000313|RefSeq:XP_016706283.1, ECO:0000313|RefSeq:XP_016706285.1}
RP IDENTIFICATION.
RC TISSUE=Leaf {ECO:0000313|RefSeq:XP_016706283.1,
RC ECO:0000313|RefSeq:XP_016706285.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_016706283.1; XM_016850794.1.
DR RefSeq; XP_016706285.1; XM_016850796.1.
DR RefSeq; XP_016706286.1; XM_016850797.1.
DR OrthoDB; 5395569at2759; -.
DR Proteomes; UP000189702; Chromosome 25.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd00159; RhoGAP; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR InterPro; IPR025757; MIP1_Leuzipper.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR PANTHER; PTHR46265; RHO GTPASE-ACTIVATING PROTEIN 7; 1.
DR PANTHER; PTHR46265:SF22; RHO GTPASE-ACTIVATING PROTEIN REN1-LIKE ISOFORM X1; 1.
DR Pfam; PF14389; Lzipper-MIP1; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50238; RHOGAP; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000189702}.
FT DOMAIN 93..200
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 247..446
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT REGION 1..74
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 451..642
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 781..820
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..28
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 53..69
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 460..520
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 562..594
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 791..806
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 831 AA; 91316 MW; 0952DF735BD3DB82 CRC64;
MATKRDEPSL IQQRIHSKRE EPSQSQLKMA SRKEEPAPAQ LKMAIKKEDP SVLQQRMASK
REDREPSQGH QGDVAAAAAP GSLEYQNSRS GNTVLKSGPL FLSSKGIGWT SWKKRWFILT
HTSLVFFRSD PNAVSQKGNE VNLTLGGIDL NNSGSVIVKA DKKLITVQFQ DGRDGRTFTL
KAETLDDLFE WKAALENALS QAPSSANAMG QNGIFRNDQS EEVDASREPA NDKPPVRSTV
IGRPVLLALE DVDGAPTFLE KALKFIEEHG VRVEGILRQA ADVEDVKRRI QEYEQGKTEF
SSEEDAHVIG DCVKYILREL PSSPVPASCC NALLEACRTQ RGSRVNAMRL AVLDTFPEPN
RRLLQRILMM MQVVASHKNE NLMSTSAVAA CMAPLLLRPL LAGDCEIETD FDVGGDGSMQ
LLQAAAAANH AQAIVITLLE EYNQIFGEGS ISSDLYSDSE ESGSESEEAA EDDSEPYDED
ESYEDDECDD ETEGSDVSND NDEEDGDDDD DDDDDDDAPS ETGSESGHSV TSDVDVDKDS
DSSSSSSESS ETGHDVKATK RLSSSIHNPS SGNDGSERSK GNQSKSTATL TKKSAELSKG
VHGPTNVEDR LAHHAQIPSS QQSAAAAHRA RRNAVWGRTS ARKNLSMESI DYPFGEEFEI
ETVEDEKSDL QNRLREEIEG NTKLEASVEK RKKTLQGRQL CLEKEVAILK EELQRERDKR
TALESVLNSS QEQPTVLPAK IDEKTKADLN DIALAEADII KLKKKVEDLE MQLNQQLEKK
SAYMNDSCRQ RQPNHHAKKE DKPKGSGAVV KGSGSKVNSH SFETACSTVV Y
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