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Database: UniProt
Entry: A0A1U8L3U4_GOSHI
LinkDB: A0A1U8L3U4_GOSHI
Original site: A0A1U8L3U4_GOSHI 
ID   A0A1U8L3U4_GOSHI        Unreviewed;      1356 AA.
AC   A0A1U8L3U4;
DT   10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT   10-MAY-2017, sequence version 1.
DT   31-JUL-2019, entry version 16.
DE   SubName: Full=endoribonuclease Dicer homolog 2-like isoform X2 {ECO:0000313|RefSeq:XP_016707739.1};
GN   Name=LOC107922284 {ECO:0000313|RefSeq:XP_016707739.1};
OS   Gossypium hirsutum (Upland cotton) (Gossypium mexicanum).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae;
OC   Pentapetalae; rosids; malvids; Malvales; Malvaceae; Malvoideae;
OC   Gossypium.
OX   NCBI_TaxID=3635 {ECO:0000313|Proteomes:UP000189702, ECO:0000313|RefSeq:XP_016707739.1};
RN   [1] {ECO:0000313|Proteomes:UP000189702}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. TM-1 {ECO:0000313|Proteomes:UP000189702};
RX   PubMed=25893780; DOI=10.1038/nbt.3208;
RA   Li F., Fan G., Lu C., Xiao G., Zou C., Kohel R.J., Ma Z., Shang H.,
RA   Ma X., Wu J., Liang X., Huang G., Percy R.G., Liu K., Yang W.,
RA   Chen W., Du X., Shi C., Yuan Y., Ye W., Liu X., Zhang X., Liu W.,
RA   Wei H., Wei S., Huang G., Zhang X., Zhu S., Zhang H., Sun F., Wang X.,
RA   Liang J., Wang J., He Q., Huang L., Wang J., Cui J., Song G., Wang K.,
RA   Xu X., Yu J.Z., Zhu Y., Yu S.;
RT   "Genome sequence of cultivated Upland cotton (Gossypium hirsutum TM-1)
RT   provides insights into genome evolution.";
RL   Nat. Biotechnol. 33:524-530(2015).
RN   [2] {ECO:0000313|RefSeq:XP_016707739.1}
RP   IDENTIFICATION.
RC   TISSUE=Leaf {ECO:0000313|RefSeq:XP_016707739.1};
RG   RefSeq;
RL   Submitted (APR-2017) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the helicase family. Dicer subfamily.
CC       {ECO:0000256|PROSITE-ProRule:PRU00657}.
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DR   RefSeq; XP_016707739.1; XM_016852250.1.
DR   GeneID; 107922284; -.
DR   Proteomes; UP000189702; Genome assembly.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0004525; F:ribonuclease III activity; IEA:InterPro.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0031047; P:gene silencing by RNA; IEA:UniProtKB-KW.
DR   GO; GO:0006396; P:RNA processing; IEA:InterPro.
DR   CDD; cd00593; RIBOc; 2.
DR   Gene3D; 1.10.1520.10; -; 2.
DR   Gene3D; 3.30.160.380; -; 1.
DR   InterPro; IPR038248; Dicer_dimer_sf.
DR   InterPro; IPR005034; Dicer_dimerisation_dom.
DR   InterPro; IPR014720; dsRBD_dom.
DR   InterPro; IPR006935; Helicase/UvrB_N.
DR   InterPro; IPR014001; Helicase_ATP-bd.
DR   InterPro; IPR001650; Helicase_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR003100; PAZ_dom.
DR   InterPro; IPR036085; PAZ_dom_sf.
DR   InterPro; IPR000999; RNase_III_dom.
DR   InterPro; IPR036389; RNase_III_sf.
DR   Pfam; PF03368; Dicer_dimer; 1.
DR   Pfam; PF00035; dsrm; 1.
DR   Pfam; PF00271; Helicase_C; 1.
DR   Pfam; PF02170; PAZ; 1.
DR   Pfam; PF04851; ResIII; 1.
DR   Pfam; PF00636; Ribonuclease_3; 2.
DR   SMART; SM00487; DEXDc; 1.
DR   SMART; SM00490; HELICc; 1.
DR   SMART; SM00949; PAZ; 1.
DR   SMART; SM00535; RIBOc; 2.
DR   SUPFAM; SSF101690; SSF101690; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF69065; SSF69065; 2.
DR   PROSITE; PS51327; DICER_DSRBF; 1.
DR   PROSITE; PS50137; DS_RBD; 1.
DR   PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR   PROSITE; PS51194; HELICASE_CTER; 1.
DR   PROSITE; PS50821; PAZ; 1.
DR   PROSITE; PS00517; RNASE_3_1; 1.
DR   PROSITE; PS50142; RNASE_3_2; 2.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000189702};
KW   Reference proteome {ECO:0000313|Proteomes:UP000189702};
KW   RNA-binding {ECO:0000256|PROSITE-ProRule:PRU00266};
KW   RNA-mediated gene silencing {ECO:0000256|SAAS:SAAS00703041}.
FT   DOMAIN       29    194       Helicase ATP-binding.
FT                                {ECO:0000259|PROSITE:PS51192}.
FT   DOMAIN      344    505       Helicase C-terminal.
FT                                {ECO:0000259|PROSITE:PS51194}.
FT   DOMAIN      524    610       Dicer dsRNA-binding fold.
FT                                {ECO:0000259|PROSITE:PS51327}.
FT   DOMAIN      801    894       PAZ. {ECO:0000259|PROSITE:PS50821}.
FT   DOMAIN      920   1076       RNase III. {ECO:0000259|PROSITE:PS50142}.
FT   DOMAIN     1112   1259       RNase III. {ECO:0000259|PROSITE:PS50142}.
FT   DOMAIN     1285   1352       DRBM. {ECO:0000259|PROSITE:PS50137}.
SQ   SEQUENCE   1356 AA;  154062 MW;  7644E6BEF5ECB82A CRC64;
     MEPVGMEMNN SQQHSSDPLP FARSYQLEAL EKAIKQNTIA YLETGSGKTL IAIMLLRRYA
     YLIRKPSPFN AVFLVPQVVL VEQQADAVEM HTDLNVGKYW GDMEVDFWDD AKWKQEIDKY
     EVLVMTPQIL LNGLRHGFFK INMIKVLIID ECHHARGKHP YASIMTEFYH RQLEAGVSDL
     PRIFGMTASP INTKGANSAD SYWQKIHELE TIMNSKVYTC VSESVLAQFV PFSTPKFKFY
     QDMEIPYVLY ARLVQELNVL KVKHECSLDN LDLEASAAES TRRKISKIHS ALIHCLDELG
     VWLALKIQIG PSLMMLKPVW MMGFLPQKFY ALLNLFLNTG NTVFTKWVLR DIRCIIFVER
     IITAVVLQSL FSELLPKYGN WKTKYIAGNN SGLQNQTRKK QNEIVEEFRK GMVNIIVATS
     ILEEGLDVQA CNLIIRFDPS PTVCSFIQSR GRARMQNSDY LLMVKSGDFS THSRLKNYLT
     SGDVMRKESL CHASDPCSPL SNDLCDEEFY HVASTGAFMT LSSSVGLIYF YCSRLPADGY
     FKPTLRCIID KQMGVCTLHL PKSSPIRTVC VKGNFKSLKQ KACFEACKQL HQIGALTDNL
     VPDIVVEEND VEEIGKESYN DDQPIFFPPE LVNQDSQESM TKYYCYLMEL KQNFGYEFPV
     QNIILLVRSQ LEMEAKSVGI ELEVDRGTLT VNLKYIGLIR LSSDQVILCR RFQIALFRVL
     MDHKAEKLTE LSDLTSGNNS EIDYLLLPSN YMGQNPVIDW LSISSILFSY EKVWKNHVNC
     NAGMIQTKSG LVCTCMIKNS LVSTHNGRTY IIDGLLNNIN ANSLLTLSDG GVMTYKEYYE
     QRHGIHLCFS RVSFLAGRHI FPVQNHIQRC KKQKEKESSN AFVELPPELC DVIMSPISIS
     TFYSFTFLPS IMHRLESLLL ATILKKMLLD HCVHNVAIPT MKVLEAITTK KCLESFHLES
     LETLGDSFLK YAVCQQLFKK HQNHHEGLLS IRKDKMISNT TLCMLGCDKK LPGFICDEPF
     DPKGWMVPGY NCGRHTLNEE KLNTRKIYVS GRRKLKSKKV ADVVEALIGA YLSTGGEVAA
     LLFMNWIGIT IDFRNIPYER HFEVQAEKIV NVQHLESLLN YSFQDPSLLV EALTHGSYML
     AEIPGCYQRL EFLGDSVLDY LITRHLYNKY PGISPGLLTD LRSASVNNNC YALSAVKAGL
     HKHILQSSQK LYKHIKETVE SFQELSLDCT FGWESEKSFP KVLGDVMESL AGAIFVDSGY
     NKETVFRSIR PLLEPLITLE TMTVHPVKEL NELCQKKHYE RRKPIVSHGN GVSSVTIEVE
     ANGEVLKHTS TACDKKMAKK LASKEILKSL KLANFC
//
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