ID A0A1U8L9I9_GOSHI Unreviewed; 772 AA.
AC A0A1U8L9I9;
DT 10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT 10-MAY-2017, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE SubName: Full=Calcium permeable stress-gated cation channel 1-like {ECO:0000313|RefSeq:XP_016711271.1};
GN Name=LOC107925181 {ECO:0000313|RefSeq:XP_016711271.1};
OS Gossypium hirsutum (Upland cotton) (Gossypium mexicanum).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Malvales; Malvaceae; Malvoideae; Gossypium.
OX NCBI_TaxID=3635 {ECO:0000313|Proteomes:UP000189702, ECO:0000313|RefSeq:XP_016711271.1};
RN [1] {ECO:0000313|Proteomes:UP000189702}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. TM-1 {ECO:0000313|Proteomes:UP000189702};
RX PubMed=25893780; DOI=10.1038/nbt.3208;
RA Li F., Fan G., Lu C., Xiao G., Zou C., Kohel R.J., Ma Z., Shang H., Ma X.,
RA Wu J., Liang X., Huang G., Percy R.G., Liu K., Yang W., Chen W., Du X.,
RA Shi C., Yuan Y., Ye W., Liu X., Zhang X., Liu W., Wei H., Wei S., Huang G.,
RA Zhang X., Zhu S., Zhang H., Sun F., Wang X., Liang J., Wang J., He Q.,
RA Huang L., Wang J., Cui J., Song G., Wang K., Xu X., Yu J.Z., Zhu Y., Yu S.;
RT "Genome sequence of cultivated Upland cotton (Gossypium hirsutum TM-1)
RT provides insights into genome evolution.";
RL Nat. Biotechnol. 33:524-530(2015).
RN [2] {ECO:0000313|RefSeq:XP_016711271.1}
RP IDENTIFICATION.
RC TISSUE=Leaf {ECO:0000313|RefSeq:XP_016711271.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the CSC1 (TC 1.A.17) family.
CC {ECO:0000256|ARBA:ARBA00007779}.
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DR RefSeq; XP_016711271.1; XM_016855782.1.
DR AlphaFoldDB; A0A1U8L9I9; -.
DR PaxDb; 3635-A0A1U8L9I9; -.
DR GeneID; 107925181; -.
DR KEGG; ghi:107925181; -.
DR OMA; WTNNELE; -.
DR OrthoDB; 1753647at2759; -.
DR Proteomes; UP000189702; Unplaced.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0005227; F:calcium-activated cation channel activity; IBA:GO_Central.
DR InterPro; IPR045122; Csc1-like.
DR InterPro; IPR003864; CSC1/OSCA1-like_7TM.
DR InterPro; IPR027815; CSC1/OSCA1-like_cyt.
DR InterPro; IPR032880; Csc1/OSCA1-like_N.
DR PANTHER; PTHR13018; PROBABLE MEMBRANE PROTEIN DUF221-RELATED; 1.
DR PANTHER; PTHR13018:SF93; PROTEIN OSCA1; 1.
DR Pfam; PF14703; PHM7_cyt; 1.
DR Pfam; PF02714; RSN1_7TM; 1.
DR Pfam; PF13967; RSN1_TM; 1.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023303};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000189702};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 6..28
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 101..120
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 157..176
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 374..398
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 418..445
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 466..485
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 514..533
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 573..603
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 625..645
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 652..669
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 7..178
FT /note="CSC1/OSCA1-like N-terminal transmembrane"
FT /evidence="ECO:0000259|Pfam:PF13967"
FT DOMAIN 199..361
FT /note="CSC1/OSCA1-like cytosolic"
FT /evidence="ECO:0000259|Pfam:PF14703"
FT DOMAIN 372..644
FT /note="CSC1/OSCA1-like 7TM region"
FT /evidence="ECO:0000259|Pfam:PF02714"
FT REGION 722..772
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 733..756
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 772 AA; 87913 MW; 2F42189945E98FB2 CRC64;
MATLGDIGVA AAFNLLSAFV FFIAFAVLRL QPFNDRVYFP KWYLKGLRTS PASSGAFVRK
FVNLDFRSYL KFLNWMPEAL KMPELELIDH AGLDSAVYLR IYLIGLKIFV PITIVAWAVL
VPVNYTNKTL ELQLKNVTSS NIDKLSISNI PLESDRFWTH IVMAYAFTFW TCFVLLKEYE
MVASMRLHFL ASEKRRPDQF TVLVRNVPPD PDESVSETVE HFFLVNHPDT YLTNQVVCNA
NKLAKLVKQR KKKQNWLDYY QLKYSRNNAQ RPIMKTGFLG LCGQKVDAIE HHEAEIKKLS
KEIAEERERV NKDPKAIMPA AFVSFKSRWG AAVCAQTQQS RDPTSWLTEW APEPCDVYWP
NLPIPYVSLA IRRLIMAVAF FFLTFFFIIP IASVQALASI EGLEKVAPFL KPIIDMKFIK
SVIQGILPGL ALKLFLIFLP TILMIMAKFE GFTSKSSLER RAATRYYLFN LVNVFLGSIV
AGSALEQLNT FIKQSANEIP RTIGVAVPLR ATFFITYIMV DGWAGIAGEI LMLKPLIIYH
LKNFFLVKTE KDREEAMDPG SLGFNTGEPQ IQLYFLLGLV YAAVTPALLP FIVIFFGLAY
VVFRHQIINV YNQEYESAAA FWPDVHGRII IALLISQVAL IGLLTSKKAA QSTPFLIALV
VLTIWFYTFC KARYEPAFVR YPLQEAMMKD TLERAREPNL NLKPYLQNAY IHPVFKEEDE
EDEFDFKSEN ESVLVPTKRQ SRRSTPAPSR ISGASSPSLP PEVVPEHPER AS
//
