ID A0A1U8LGP9_GOSHI Unreviewed; 1218 AA.
AC A0A1U8LGP9;
DT 10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT 10-MAY-2017, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE RecName: Full=DNA helicase {ECO:0000256|ARBA:ARBA00012551};
DE EC=3.6.4.12 {ECO:0000256|ARBA:ARBA00012551};
GN Name=LOC107926069 {ECO:0000313|RefSeq:XP_016712344.1};
OS Gossypium hirsutum (Upland cotton) (Gossypium mexicanum).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Malvales; Malvaceae; Malvoideae; Gossypium.
OX NCBI_TaxID=3635 {ECO:0000313|Proteomes:UP000189702, ECO:0000313|RefSeq:XP_016712344.1};
RN [1] {ECO:0000313|Proteomes:UP000189702}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. TM-1 {ECO:0000313|Proteomes:UP000189702};
RX PubMed=25893780; DOI=10.1038/nbt.3208;
RA Li F., Fan G., Lu C., Xiao G., Zou C., Kohel R.J., Ma Z., Shang H., Ma X.,
RA Wu J., Liang X., Huang G., Percy R.G., Liu K., Yang W., Chen W., Du X.,
RA Shi C., Yuan Y., Ye W., Liu X., Zhang X., Liu W., Wei H., Wei S., Huang G.,
RA Zhang X., Zhu S., Zhang H., Sun F., Wang X., Liang J., Wang J., He Q.,
RA Huang L., Wang J., Cui J., Song G., Wang K., Xu X., Yu J.Z., Zhu Y., Yu S.;
RT "Genome sequence of cultivated Upland cotton (Gossypium hirsutum TM-1)
RT provides insights into genome evolution.";
RL Nat. Biotechnol. 33:524-530(2015).
RN [2] {ECO:0000313|RefSeq:XP_016712344.1}
RP IDENTIFICATION.
RC TISSUE=Leaf {ECO:0000313|RefSeq:XP_016712344.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
CC Evidence={ECO:0000256|ARBA:ARBA00001665};
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DR RefSeq; XP_016712344.1; XM_016856855.1.
DR AlphaFoldDB; A0A1U8LGP9; -.
DR STRING; 3635.A0A1U8LGP9; -.
DR PaxDb; 3635-A0A1U8LGP9; -.
DR GeneID; 107926069; -.
DR KEGG; ghi:107926069; -.
DR OrthoDB; 57056at2759; -.
DR Proteomes; UP000189702; Unplaced.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0003724; F:RNA helicase activity; IBA:GO_Central.
DR GO; GO:0006401; P:RNA catabolic process; IBA:GO_Central.
DR CDD; cd18023; DEXHc_HFM1; 1.
DR CDD; cd18795; SF2_C_Ski2; 1.
DR Gene3D; 1.10.150.20; 5' to 3' exonuclease, C-terminal subdomain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR Gene3D; 1.10.3380.10; Sec63 N-terminal domain-like domain; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR004179; Sec63-dom.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR PANTHER; PTHR47835; HFM1, ATP DEPENDENT DNA HELICASE HOMOLOG; 1.
DR PANTHER; PTHR47835:SF2; SEC63 DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF14520; HHH_5; 1.
DR Pfam; PF02889; Sec63; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SMART; SM00973; Sec63; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF158702; Sec63 N-terminal domain-like; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Helicase {ECO:0000256|ARBA:ARBA00022806,
KW ECO:0000313|RefSeq:XP_016712344.1};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000189702}.
FT DOMAIN 34..229
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 263..460
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT REGION 889..908
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1116..1148
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1173..1201
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1174..1189
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1218 AA; 136490 MW; 0D7484632C6CE326 CRC64;
MDSYSLKSVF DLPEPFRSIF NFRYFNSLQS ECFPVCFLSD VNMVISAPTG SGKTVLFELC
ILRLLSRFIS GDGRFVHIKG TLKTIYIAPS KALVQEKLRD WTQKFGSLGI SCLELTGDND
SYSTRNIQEA DIILTTPEKF DAVTRYRIKD GGLSFFSDIS LLLIDEVHLL NDLRGATLEA
IVSRIKMLAR NPEMKSSALA SVRFLAVSAT IPNTEDLAEW LEVPVQGIKR FGEEMRPVKL
TTKVFGYASA KNDFLFEKRL QNYIFDILMQ YSRGKSALVF CSTRSGAQEA AQRLSQIVMT
FGYSNPFIKS SEQQERLREA SLSCSDKQMQ SYILYGVGYH NGGLSLKDRN LIECLFLNGD
VQVLCTTNTL AHGINLPAHT VVIKSTQHFN KEKGLYMEYD RSMILQMCGR AGRPPFEDTG
MVIIMTRRET VHLYENLLNG CEMVESQLLS CLTEHLTAEI VQLTISDITK AIEWMKCSYL
YVRMKKNPGN YAVKKGIRRE QVEKHMQEIC VQNVNELSCH QMVQTDQEGF ALKPQEPGRL
MTKYYLKFNT MKHIMQAPSS CSLEEVLQII CHAEEIAWIQ LRRNEKKVLN DLNGDKDGRL
RFHVTGDKGK RKKRIQTREE KIFVLANDCL TGDPLVPDLS MTQDANSICS NGARIAKCMK
EYFIYKKNYR GALNSSLLAK SLYQKLWDDS PYLLKQLPGI GMVTAKALHS MGIKSFETLA
EADPRRIELV TGRKFPFGNH IKESLTSLPP KVDIKIEVSE CQRQGKSKLA VTLTRLSSQG
VQSTKRHYAD MIVASEEDNL ILFHEKISRV DEFLSPYSTT TLVSNPLGKM TIKADLVFEE
YIGVDLHEKL LLVKESNSNA NLKRARKPTQ FFAPEEVYVI EDDNAATHKS FAQRPPDSIG
SKRESSSMPS FNLLDEELEG EFAAGIENDD CKIITEQSIF DHIREKAKNF PLLTPNNAYS
PSSGGLILTR KRSSDQEKSK IRQHILLDPL PESTGHEQIA DDHNNYLTGK HHITAGSSVT
INLTDESGYL PSEPEAFSFK SLTEEAIFDH IRKKSKHFPV INTPKPIDTD CCICTEEHNS
ANQPESGNAT LGTSKYAMVI SEPEPGEVNR DACGTKVGTK TKNNVLQGSS GGANGESAVS
PKVSSTKTAT SSVQMLSFDI SMAKNSKHLA DLGSSIQDGR KDKPSPSDSK RQSRSLASTD
QAREVGSFLG FQSVFSFL
//
