ID A0A1U8LIJ8_GOSHI Unreviewed; 560 AA.
AC A0A1U8LIJ8;
DT 10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT 10-MAY-2017, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE RecName: Full=Protein DETOXIFICATION {ECO:0000256|RuleBase:RU004914};
DE AltName: Full=Multidrug and toxic compound extrusion protein {ECO:0000256|RuleBase:RU004914};
GN Name=LOC107927810 {ECO:0000313|RefSeq:XP_016714422.1};
OS Gossypium hirsutum (Upland cotton) (Gossypium mexicanum).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Malvales; Malvaceae; Malvoideae; Gossypium.
OX NCBI_TaxID=3635 {ECO:0000313|Proteomes:UP000189702, ECO:0000313|RefSeq:XP_016714422.1};
RN [1] {ECO:0000313|Proteomes:UP000189702}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. TM-1 {ECO:0000313|Proteomes:UP000189702};
RX PubMed=25893780; DOI=10.1038/nbt.3208;
RA Li F., Fan G., Lu C., Xiao G., Zou C., Kohel R.J., Ma Z., Shang H., Ma X.,
RA Wu J., Liang X., Huang G., Percy R.G., Liu K., Yang W., Chen W., Du X.,
RA Shi C., Yuan Y., Ye W., Liu X., Zhang X., Liu W., Wei H., Wei S., Huang G.,
RA Zhang X., Zhu S., Zhang H., Sun F., Wang X., Liang J., Wang J., He Q.,
RA Huang L., Wang J., Cui J., Song G., Wang K., Xu X., Yu J.Z., Zhu Y., Yu S.;
RT "Genome sequence of cultivated Upland cotton (Gossypium hirsutum TM-1)
RT provides insights into genome evolution.";
RL Nat. Biotechnol. 33:524-530(2015).
RN [2] {ECO:0000313|RefSeq:XP_016714422.1}
RP IDENTIFICATION.
RC TISSUE=Leaf {ECO:0000313|RefSeq:XP_016714422.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the multi antimicrobial extrusion (MATE) (TC
CC 2.A.66.1) family. {ECO:0000256|ARBA:ARBA00010199,
CC ECO:0000256|RuleBase:RU004914}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|RuleBase:RU004914}.
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DR RefSeq; XP_016714422.1; XM_016858933.1.
DR AlphaFoldDB; A0A1U8LIJ8; -.
DR STRING; 3635.A0A1U8LIJ8; -.
DR PaxDb; 3635-A0A1U8LIJ8; -.
DR GeneID; 107927810; -.
DR KEGG; ghi:107927810; -.
DR OrthoDB; 296207at2759; -.
DR Proteomes; UP000189702; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015297; F:antiporter activity; IEA:InterPro.
DR GO; GO:0042910; F:xenobiotic transmembrane transporter activity; IEA:InterPro.
DR CDD; cd13136; MATE_DinF_like; 1.
DR InterPro; IPR044644; DinF-like.
DR InterPro; IPR002528; MATE_fam.
DR PANTHER; PTHR42893; PROTEIN DETOXIFICATION 44, CHLOROPLASTIC-RELATED; 1.
DR PANTHER; PTHR42893:SF9; PROTEIN DETOXIFICATION 46, CHLOROPLASTIC; 1.
DR Pfam; PF01554; MatE; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|RuleBase:RU004914};
KW Reference proteome {ECO:0000313|Proteomes:UP000189702};
KW Transmembrane {ECO:0000256|RuleBase:RU004914};
KW Transmembrane helix {ECO:0000256|RuleBase:RU004914}.
FT TRANSMEM 106..131
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU004914"
FT TRANSMEM 151..171
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU004914"
FT TRANSMEM 183..204
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU004914"
FT TRANSMEM 278..300
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU004914"
FT TRANSMEM 421..440
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU004914"
SQ SEQUENCE 560 AA; 60929 MW; 6A12536FDEF42307 CRC64;
MMLTSKTLIQ PPSIHLQNPN LKLSPSIPKR STFSSLPFHR SFLLSFSHNL TPQNPSRHCI
SPGQELSYEN EDLVEEQNEE EEVEISREIK GEGLANQSIW NQMKEIVMFT GPATGLWLCG
PLMSLIDTAV IGQGSSIELA ALGPATVVCD YTGYMFMFLS IATSNMVATS LARRDKNGVQ
HQISILLFIG LFCGFLMLIL TRFFGSWALT AFSGPKNAHL VPAGNTYVQI RSLAWPAVLV
GWVAQSASLG MKDSWGPLKA LAVSSAINGI GDVALCMFLG YGIAGAAWAT MVSQVVAAYM
MIDALNKKGY NAFAISIPTF EELLSVLAIA GPVFVTLTAK VIFYSVLVYF ATSMGTHTVA
AHQVLLQTYA MCTVWGKPLS QTAQSFMPEL IYGVNRSLPK VRDLNFNFPA SAVARMLLKS
LVTIGATLGL VLGIIGTAVP RFFPNIFTPD VKVIQEMHKV LLPYFLALAI TPSTHSLEGT
LLAGRDLRFI SLSMTGCLAF GALIPPLLTS TGCGLASCWF ALMGFQWARF FLSLQRLLSP
NGILYSEDLT RFELKDMKAS
//
