ID A0A1U8LL41_GOSHI Unreviewed; 1010 AA.
AC A0A1U8LL41;
DT 10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT 10-MAY-2017, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Retinoblastoma-related protein-like isoform X4 {ECO:0000313|RefSeq:XP_016714178.1};
GN Name=LOC107927587 {ECO:0000313|RefSeq:XP_016714178.1};
OS Gossypium hirsutum (Upland cotton) (Gossypium mexicanum).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Malvales; Malvaceae; Malvoideae; Gossypium.
OX NCBI_TaxID=3635 {ECO:0000313|Proteomes:UP000189702, ECO:0000313|RefSeq:XP_016714178.1};
RN [1] {ECO:0000313|Proteomes:UP000189702}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. TM-1 {ECO:0000313|Proteomes:UP000189702};
RX PubMed=25893780; DOI=10.1038/nbt.3208;
RA Li F., Fan G., Lu C., Xiao G., Zou C., Kohel R.J., Ma Z., Shang H., Ma X.,
RA Wu J., Liang X., Huang G., Percy R.G., Liu K., Yang W., Chen W., Du X.,
RA Shi C., Yuan Y., Ye W., Liu X., Zhang X., Liu W., Wei H., Wei S., Huang G.,
RA Zhang X., Zhu S., Zhang H., Sun F., Wang X., Liang J., Wang J., He Q.,
RA Huang L., Wang J., Cui J., Song G., Wang K., Xu X., Yu J.Z., Zhu Y., Yu S.;
RT "Genome sequence of cultivated Upland cotton (Gossypium hirsutum TM-1)
RT provides insights into genome evolution.";
RL Nat. Biotechnol. 33:524-530(2015).
RN [2] {ECO:0000313|RefSeq:XP_016714178.1}
RP IDENTIFICATION.
RC TISSUE=Leaf {ECO:0000313|RefSeq:XP_016714178.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the retinoblastoma protein (RB) family.
CC {ECO:0000256|ARBA:ARBA00009475}.
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DR RefSeq; XP_016714178.1; XM_016858689.1.
DR AlphaFoldDB; A0A1U8LL41; -.
DR GeneID; 107927587; -.
DR OrthoDB; 519973at2759; -.
DR Proteomes; UP000189702; Unplaced.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0051726; P:regulation of cell cycle; IEA:InterPro.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR Gene3D; 1.10.472.140; -; 1.
DR Gene3D; 1.10.472.10; Cyclin-like; 2.
DR InterPro; IPR036915; Cyclin-like_sf.
DR InterPro; IPR002720; RB_A.
DR InterPro; IPR002719; RB_B.
DR InterPro; IPR028309; RB_fam.
DR InterPro; IPR024599; RB_N.
DR PANTHER; PTHR13742:SF17; RETINOBLASTOMA-ASSOCIATED PROTEIN; 1.
DR PANTHER; PTHR13742; RETINOBLASTOMA-ASSOCIATED PROTEIN RB -RELATED; 1.
DR Pfam; PF11934; DUF3452; 1.
DR Pfam; PF01858; RB_A; 1.
DR Pfam; PF01857; RB_B; 1.
DR SMART; SM01367; DUF3452; 1.
DR SMART; SM01368; RB_A; 1.
DR SUPFAM; SSF47954; Cyclin-like; 2.
PE 3: Inferred from homology;
KW Cell cycle {ECO:0000256|ARBA:ARBA00023306};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000189702};
KW Repressor {ECO:0000256|ARBA:ARBA00022491};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 82..231
FT /note="Retinoblastoma-associated protein N-terminal"
FT /evidence="ECO:0000259|SMART:SM01367"
FT DOMAIN 413..612
FT /note="Retinoblastoma-associated protein A-box"
FT /evidence="ECO:0000259|SMART:SM01368"
FT REGION 382..405
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 648..671
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 872..902
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 648..669
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 872..889
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1010 AA; 111655 MW; 2E693E66631F6911 CRC64;
MEDTKPSVAT SGGTDGDAVE ARFNALCKNG LSLDEKACSN AMKLFKETKH LLTSNVSSIG
SGTLEEAERF WFSFVLYSLK RLSEKIGENT QQESDESGFS FCQILRATKL NIVDCFKELP
QFVVKAGPVL RNMYGEDWET RLEGTEMQAN FVHLSLLSKS YKRAFWELFL TSDANIDKQQ
NATSSSDYIS ECHRFGWLLF LALRVHAFSR FKDLVTCANG FVSILAILII HVPVRFRNFK
INDSPHFVKK GDKGVDLLAS LCNMYDASED DLRKTMETAN KLIEEILKKK PCPAAECKTE
TLENIDTDSL IYFEGLMEEK SLSSSLNMLE KDYDNAICNK GDLDERVFVN DEDSLLGLGS
FSGGTMNVTG IKRKFDSVAS PSKSISSPLS PQRPPASHAN GVLGPPSAKM AATPVSAAMT
TAKWLRSVIC PLSSKPSAEL QRFLSSCDKD VTNDVICRAH IILEAIFPRN QECSVTGSLQ
SVNLMDNIWM EQRILEALKL YYRVLEAMCT AEALILHAPN LTSLLTNERF HRCMLACSAE
LVLATHKTAT MLFPTVLERT SITAFDLSKV IESFIRHEES LPRELRRHLN SLEERLLESM
VWDKGSSMYN SLIVAKPALS AEINRLGLLA EPMPPLDAIA THVNFSGSTP PVPSLQKHET
STGQNGDVRS PMRPCTELRS VLVERNAFTS PVKDRLLALN SLKKAPLQSA FASPTRPNPG
GGGETCAETG ISIFFGKINK LAAVRINGMV ERLQLSQQIR ESVYSLFQKI LNQRTSLFFN
RHIDQIILCC FYVVAKISQL RLTFKEIICN YRKQPQCKPQ VFQSVFVDRS SARRNGRTGQ
DNVDIIAFYN EIFVPSIKPL LGELGSAGTT TRTSRVAEAN NSNDGTCPGS PKVSPFPSLP
DMSPKKVSAT HNVYVSPLRT SKMDALISHS SRSYYACVGE STRAYQSPSK DLTAINNHLN
GGRKIRGALN FDDVDVGLVS DSMVANSLYL QNGSCASSSG APLKSEQPES
//
